Publications by authors named "Maali Alahmad"
Reactive oxygen species (ROS) serve vital physiological functions, but aberrant ROS production contributes to numerous diseases. Unfortunately, therapeutic progress targeting pathogenic ROS has been hindered by the limited understanding of whether the mechanisms driving pathogenic ROS differ from those governing physiological ROS generation. To address this knowledge gap, we utilised a cellular model of Parkinson's disease (PD), as an exemplar of ROS-associated diseases.
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- * A study found a significant correlation between levels of C3a, a breakdown product of complement C3, and cognitive impairments in NMO patients, indicating that C3a may negatively impact neuronal development.
- * Reducing C3 levels in astrocytes improved cognitive functions and neuronal development in mouse models of NMO, suggesting that targeting the C3-C3aR signaling pathway could be a viable treatment strategy for cognitive impairments associated with autoimmune diseases like NMO.