Publications by authors named "Maaike van Ochten"
Background: Pregnancy is characterized by profound circulatory changes and compensatory adjustments in the renin-angiotensin-aldosterone system (RAAS). Differences in regulatory response may antedate or accompany vascular complicated pregnancy. We performed a systematic review and meta-analysis to delineate the trajectory of active plasma renin concentration (APRC) in healthy pregnancy and compare this to complicated pregnancy.
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- The maternal cardiovascular system adapts during pregnancy to support the fetus, but improper adjustments can lead to hypertension.
- A new mathematical model for renal autoregulation was developed to integrate with existing cardiovascular models for better understanding of pregnancy-related circulatory changes.
- The model successfully matched empirical data, demonstrating the accuracy of autoregulatory responses; future research should add more regulatory aspects to explore hemodynamic changes during pregnancy complications.