Optimization of the radiation dosimetry protocol in Lutetium-177-PSMA therapy: toward clinical implementation.

Background: Dosimetry in [Lu]Lu-PSMA therapy is a valuable tool to assess treatment efficacy and toxicity. This study aims to develop a clinically implementable protocol to determine the absorbed dose in organs and tumor lesions after [Lu]Lu-PSMA-617 therapy, by reducing the imaging time points and utilizing population-based kinetics with a single scan, with evaluation of its influence on the uncertainty in absorbed dose.

Methods: Ten patients with metastatic hormone-sensitive prostate cancer received two cycles of [Lu]Lu-PSMA-617.