Publications by authors named "MaLgorzata Rolla"
Article Synopsis
- Neoplasms are a leading cause of death in patients with acromegaly, which prompted this study to analyze the incidence and types of benign and malignant tumors in these patients.
- Researchers examined the relationship between tumor prevalence, disease activity, diagnosis timing, and symptom onset, alongside hormone levels from the pituitary gland.
- The study involved a review of records from 230 acromegaly patients in Poland, revealing significantly higher rates of both benign and malignant neoplasms in active cases compared to those who had been cured.
The major causes of both morbidity and mortality in patients with acromegaly are cardiovascular diseases (CVDs). The polymorphisms of the fat mass and obesity-associated gene ( are associated with obesity, as well as with an increased risk of CVDs. The aim of the study was to determine the relationship of risk alleles of four gene polymorphisms with selected parameters of lipid and glucose metabolism as well as with IGF-1 and GH levels in the group of patients with acromegaly compared to the control group.
View Article and Find Full Text PDFAcromegaly is a rare endocrine disorder caused by somatotroph pituitary adenoma. Besides its typical symptoms, it contributes to the development of cardiovascular, metabolic, and bone comorbidities. H19 RNA is a long non-coding RNA and it is suspected to be involved in tumorigenesis, cancer progression, and metastasis.
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- The study explores how chronic exposure to impaired growth hormone (GH) and insulin-like growth factor 1 (IGF-I) in acromegaly leads to various health complications, negatively impacting quality of life and increasing the risk of early death.
- Researchers conducted a retrospective analysis of 179 patients treated for acromegaly at Wroclaw Medical University between 1976 and 2018, focusing on the prevalence of complications and diagnostic methods used.
- Results indicated that metabolic disorders were the most common complications, with a notable female predominance among patients; over 50% suffered from combined cardiac, metabolic, and endocrine issues.
Long non-coding RNAs (lncRNAs) are over 200 nucleotides long recently discovered RNA molecules that are not involved in the translation process. Accumulating evidence shows that H19 lncRNA is an important regulator of gene expression and its altered expression contributes to carcinogenesis. The aim of this review was to reveal current knowledge about H19 lncRNA and its impact on tumours of the endocrine system.
View Article and Find Full Text PDFIntroduction: Radiofrequency echographic multi-spectrometry (REMS) is a recently introduced non-ionising technology employed in the evaluation of osteoporosis. The aim of our study was to compare bone mineral density (BMD) in acromegaly patients and healthy controls by performing novel REMS densitometry. The second objective was to analyse the correlation between results of REMS and classical dual-energy X-ray absorptiometry (DXA) in acromegaly patients.
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