The NAC transcription factor LpNAC48 promotes trichome formation in Lilium pumilum.

Trichomes play a crucial role in plant resistance to abiotic and biotic stresses, and their development and characteristics vary across different species. This study demonstrates that trichomes of Lilium pumilum exhibit synchronized growth during flower bud differentiation and enhance the plant's adaptability to UV-B radiation and aphid infection. We identified LpNAC48, a NAC family transcription factor (TF), that interacted with the B-box (BBX) family TF LpBBX28, during trichome formation in L.

Alisol A inhibits and stabilizes atherosclerotic plaques by protecting vascular endothelial cells.

Background And Aims: Dysfunction of endothelial cells represents a crucial aspect in the pathogenesis of atherosclerosis. The aim of this study was to explore the protective effects of alisol A on vascular endothelial cells and its possible mechanisms.

Methods: An atherosclerosis model was established by feeding ApoE-/- mice with high-fat chow.

Automated counting and classifying Daphnia magna using machine vision.

Daphnia magna (D. magna) is a model organism widely used in aquatic ecotoxicology research due to its sensitivity to environmental changes. The survival and reproduction rates of D.

Laser-Induced Vertical Graphene Nanosheets for Electrocatalytic Hydrogen Evolution.

Efficient and affordable electrocatalysts are fundamental for the sustainable production of hydrogen from water electrolysis. Here, an approach for the rapid production of laser-induced vertical graphene nanosheets (LIVGNs) through the exfoliation of the graphite foil under laser irradiation is presented. The density of the formed LIVGNs is ∼3 per 100 μm.

The COL7A1/PI3K/AKT axis regulates the progression of cholangiocarcinoma.

Background: The role and molecular mechanisms of collagen type VII (COL7A1) in cholangiocarcinoma (CCA) remain unknown.

Methods: We analyzed the expression of COL7A1 in CCA and its relationship with patient prognosis using bioinformatic techniques. Expression levels of COL7A1 in CCA cells and tissues were detected using reverse transcription-quantitative PCR, western blotting, and immunohistochemistry.

Contributions from typical sources to microplastics in surface water of a semiarid urban river.

Urban regions are suggested to be the main source of microplastic pollution in rivers. Thus, we investigated the spatiotemporal distribution of microplastics in the surface water of the Lanzhou section of the Yellow River in a semiarid region and the contributions of typical sources. The average concentration of microplastics in the surface water of the river was 0.

Selection and characterization of spontaneous phage-resistant mutant of Limosilactobacillus fermentum.

Phage infection remains a major cause of fermentation failures in the dairy industry. The development of phage-resistant mutants of important fermentation strains is an effective measure used to address phage-related issues. This study employed the secondary culture method to screen for spontaneous phage-resistant mutants from the phage sensitive strain Limosilactobacillus fermentum IMAU32646 (L.

The effect of low-temperature straw-degrading microbes on winter wheat growth and soil improvement under straw return.

The application of straw-degrading microbes (SDMs) with straw returned to the field is an effective measure to improve soil quality, increase yield, and maintain soil microorganisms. However, the utilization of SDMs in winter in north China is limited by the poor effects at low temperatures. This study investigated the effects of a new compound SDM, including a novel low-temperature fungus sp.

G protein-coupled receptor kinase 2 as a novel therapeutic target for gland fibrosis of Sjögren's syndrome.

Sjogren's syndrome (SS) is a chronic, progressive autoimmune disorder characterized by gland fibrosis. We previously found a close correlation between gland fibrosis and the expression of G protein-coupled receptor kinase 2 (GRK2). In this study we explored the pathological and therapeutic significance of GRK2 in SS.

Efficacy and safety of platelet-rich plasma and hyaluronic acid combination therapy for knee osteoarthritis: a systematic review and meta-analysis.

Background: This study aimed to evaluate whether a combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) is more effective and safer than injection alone for treating KOA.

Materials And Methods: MEDLINE (PubMed), the Cochrane Library, EMBASE, and Web of Science databases were systematically searched for articles published until January 2024, and gray literature and bibliographic references were searched. All published randomized controlled trials (RCTs) compared pain, functional outcomes, and adverse events (AEs) associated with PRP + HA therapy vs.

Preparation and evaluation of microencapsulated delivery system of recombinant interferon alpha protein from rainbow trout.

Diseases caused by viruses pose a significant risk to the health of aquatic animals, for which there are presently no efficacious remedies. Interferon (IFN) serving as an antiviral agent, is frequently employed in clinical settings. Due to the unique living conditions of aquatic animals, traditional injection of interferon is cumbersome, time-consuming and labor-intensive.

Complete Organelle Genome of the Desiccation-Tolerant (DT) Moss and Comparative Analysis of the Pottiaceae Family.

(Sm.) Lindb. is an important component of biological soil crusts and possesses an extraordinary tolerance against desiccation in dryland habitats.

A review of MASLD-related hepatocellular carcinoma: progress in pathogenesis, early detection, and therapeutic interventions.

The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) is continuously rising, evolving into a global health challenge. Concurrently, cases of hepatocellular carcinoma (HCC) associated with MASLD are also on the increase. Although traditional risk factors such as age, gender, and metabolic factors play significant roles in the development of HCC, it cannot be overlooked that MASLD, triggered by changes in modern lifestyle and dietary habits, may also exacerbate the risk of HCC, and this phenomenon is common even among non-obese individuals.

The MdHSC70-MdWRKY75 module mediates basal apple thermotolerance by regulating the expression of heat shock factor genes.

Heat stress severely restricts the growth and fruit development of apple (Malus domestica). Little is known about the involvement of WRKY proteins in the heat tolerance mechanism in apple. In this study, we found that the apple transcription factor (TF) MdWRKY75 responds to heat and positively regulates basal thermotolerance.

Theoretical and kinetic study of the H-atom abstraction reactions by Ḣ atom from alkyl cyclohexanes.

Reaction kinetics of hydrogen atom abstraction from six alkyl cyclohexanes, methyl cyclohexane (MCH), ethyl cyclohexane (ECH), -propyl cyclohexane (PCH), iso-propyl cyclohexane (iPCH), -butyl cyclohexane (BCH) and iso-butyl cyclohexane (iBCH), by the Ḣ atom are systematically studied in this work. The M06-2X method combined with the 6-311++G(d,p) basis set is used to perform geometry optimization, frequency analysis and zero-point energy calculations for all species. The intrinsic reaction coordinate (IRC) calculations are performed to confirm the transition states connecting the reactants and products correctly.

Vertical graphene nanowalls supported hybrid WC/WO composite material as an efficient non-noble metal electrocatalyst for hydrogen evolution.

Research for the development of noble metal-free electrodes for hydrogen evolution has blossomed in recent years. Transition metal carbides compounds, such as WC, have been considered as a promising alternative to replace Pt-family metals as electrocatalysts towards hydrogen evolution reaction (HER). Moreover, hybridization of TMCs with graphene nanostructures has emerged as a reliable strategy for the preparation of compounds with high surface to volume ratio and abundant active sites.

Processing and Functionalization of Vertical Graphene Nanowalls by Laser Irradiation.

The processing of vertical graphene nanowalls (VGNWs) via laser irradiation is proposed as a means to modulate their physicochemical properties. The effects of the number of applied pulses and fluence of each pulse are examined. Raman spectroscopy studies the effect of irradiation on the chemical structure of the VGNWs.

Prevalence and natural course of incidental gastric subepithelial tumors.

Background/aims: Gastric subepithelial tumors (SETs) are often encountered during the upper gastrointestinal endoscopic screening. We assessed the prevalence of gastric SETs and the risk factors for their progression.

Methods: We reviewed the electronic medical records of 30,754 patients who underwent upper gastrointestinal endoscopic screening at our medical center between January 2013 and December 2016.

Cip1, a CDK regulator, determines heterothallic mating or homothallic selfing in a protist.

Mating type (sex) plays a crucial role in regulating sexual reproduction in most extant eukaryotes. One of the functions of mating types is ensuring self-incompatibility to some extent, thereby promoting genetic diversity. However, heterothallic mating is not always the best mating strategy.

Pairing a bioinformatics-focused course-based undergraduate research experience with specifications grading in an introductory biology classroom.

Introducing bioinformatics-focused concepts and skills in a biology classroom is difficult, especially in introductory biology classrooms. Course-based Undergraduate Research Experiences (CUREs) facilitate this process, introducing genomics and bioinformatics through authentic research experiences, but the many learning objectives needed in scientific research and communication, foundational biology concepts, and bioinformatics-focused concepts and skills can make the process challenging. Here, the pairing of specifications grading with a bioinformatics-focused CURE developed by the Genomics Education Partnership is described.