Pickering self-floating adsorbents: Natural tea polyphenol nanoparticle-based beads for efficient separation of cationic dyes with simple recovery.

Energy-efficient separation and recovery of adsorbents, particularly nano/micro-adsorbent materials, and effective adsorption of water-soluble ionic dyes continue to be crucial challenges in wastewater treatment. In this study, a novel water-suspended Pickering adsorbent with adsorption selectivity was developed using natural polyphenol nanomaterials. The preparation procedure is simple and cost-effective, involving ultrasonic emulsification and calcium alginate crosslinking without the use of complex equipment or expensive chemicals.

Responsive hydrogel modulator with self-regulated polyphenol release for accelerating diabetic wound healing precise immunoregulation.

Nonhealing chronic wounds are intractable clinical complications of diabetes and are characterized by high protease activity, severe oxidative stress and sustained inflammatory response. In this case, the development of functional hydrogel dressings to modulate the immune microenvironment is a well-known strategy, where the precise stimuli-responsive and spatiotemporally controlled release of bioactive molecules remains a huge challenge. Herein, we developed responsive hydrogels with self-regulated bioactive molecule release based on the protease activity in diabetic wound sites, to serve as a smart immune microenvironment modulator for accelerating wound healing.

Genetic colocalization of cathepsins H, D, and L1 with Alzheimer's disease: Implications for biomarker and therapeutic target discovery.

BackgroundCathepsins, a family of lysosomal proteases, have been implicated in Alzheimer's disease (AD) pathogenesis through their involvement in amyloid-β protein precursor processing and neuroinflammation. However, the specific roles of different cathepsins in AD remain unclear.ObjectiveThis study aimed to investigate the genetic associations and potential causal relationships between cathepsins and AD, using Mendelian randomization (MR) to explore their roles as biomarkers and therapeutic targets.

A Library of Polyphenol-Amino Acid Condensates for High-Throughput Continuous Flow Production of Nanomedicines with Ultra-High Drug Loading.

Synthesizing high drug-loading nanomedicines remains a formidable challenge, and achieving universally applicable, continuous, large-scale engineered production of such nanomedicines presents even greater difficulties. This study presents a scalable library of polyphenol-amino acid condensates. By selecting amino acids, the library enables precise customization of key properties, such as carrier capacity, bioactivity, and other critical attributes, offering a versatile range of options for various application scenarios.

The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism.

Mitochondrial heat shock proteins and co-chaperones play crucial roles in maintaining proteostasis by regulating unfolded proteins, usually without specific target preferences. In this study, we identify a DNAJC-type co-chaperone: T cell activation inhibitor, mitochondria (TCAIM), and demonstrate its specific binding to α-ketoglutarate dehydrogenase (OGDH), a key rate-limiting enzyme in mitochondrial metabolism. This interaction suppresses OGDH function and subsequently reduces carbohydrate catabolism in both cultured cells and murine models.

A Database on Antibiotics and Antibiotic Resistance in Wastewater and Solid Waste from Pharmaceutical Industry Based on a Systematic Review.

Residual antimicrobial agents in wastewater and solid waste from antimicrobial manufacturing facilities can potentially contaminate environments. The World Health Organization has established technical guidelines for managing antimicrobial resistance (AMR) in pharmaceutical wastewater and solid waste. However, the scarcity of publicly available data on antimicrobial manufacturing processes impedes the development of effective mitigation strategies.

[The impact and clinical implication of variants in the start codon of HBA gene on the phenotype of thalassemia].

Objective: To analyze the correlation between variants in the start codon of the α-globin gene and phenotypes of thalassemia, so as to provide a basis for the diagnosis and prevention of α-thalassemia.

Methods: A retrospective study was conducted on 7 patients diagnosed by Yangjiang People's Hospital and Guangzhou Hybribio Co. Ltd.

The Safety and Immunogenicity of a 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine (CRM197/TT) in Infants: A Double-Blind, Randomized, Phase III Trial.

Objectives: This study aimed to evaluate the immunogenicity and safety of a 13-valent pneumococcal polysaccharide conjugate vaccine (CRM197/TT) (PCV13i) in infants.

Methods: A total of 1200 infants were randomly assigned to either the experimental PCV13i group or the control PCV13 group in a 1:1 ratio. Each group received a three-dose series of the vaccine at 2, 4, and 6 months of age, followed by a booster dose at 12-15 months.

Antihypertensive effects of rice peptides involve intestinal microbiome alterations and intestinal inflammation alleviation in spontaneously hypertensive rats.

Gut dysbiosis serves as an underlying risk factor for the development of hypertension. The resolution of this dysbiosis has emerged as a promising strategy in improving hypertension. Food-derived bioactive protein peptides have become increasingly more attractive in ameliorating hypertension, primarily due to their anti-inflammatory and anti-oxidant activities.

Iron oxides promote physicochemical stabilization of carbon despite enhancing microbial activity in the rice rhizosphere.

Rice rhizosphere soil is a hotspot of microbial activity and a complex interplay between soil abiotic properties, microbial community and organic carbon (C). The iron (Fe) plaque formation in the rice rhizosphere promotes Fe-bound organic C formation and increases microbial activity. Yet, the overall impact of Fe on C storage via physicochemical stabilization and microbial mineralization of rhizodeposits (rhizo-C) and soil organic C (SOC) in the rice rhizosphere remain unclear.

:c.96-2A > G mutation: report of 7 cases in China.

Objective: To analyze the hematological phenotype and genotype of : c.96-2A > G carriers.

Methods: The blood routine parameters and hemoglobin electrophoresis of rare cases were analyzed and identified by PCR combined with reverse dot blot (RBD-PCR), GAP-PCR and DNA sequencing.

Structure and function of EfpA as a lipid transporter and its inhibition by BRD-8000.3.

EfpA, the first major facilitator superfamily (MFS) protein identified in (Mtb), is an essential efflux pump implicated in resistance to multiple drugs. EfpA-inhibitors have been developed to kill drug-tolerant Mtb. However, the biological function of EfpA has not yet been elucidated.

Microenvironment-Responsive Antibacterial, Anti-Inflammatory, and Antioxidant Pickering Emulsion Stabilized by Curcumin-Loaded Tea Polyphenol Particles for Accelerating Infected Wound Healing.

Multiphase Pickering emulsions, including two or more active agents, are of great importance to effectively manage complicated wounds. However, current strategies based on Pickering emulsions are still unsatisfying since they involve only stabilization by inactive particles and encapsulation of the hydrophobic drugs in the oil phase. Herein, thyme essential oil (TEO) was encapsulated in the shell of functional tea polyphenol (TP)-curcumin (Cur) nanoparticles (TC NPs) to exemplarily develop a novel Pickering emulsion (TEO/TC PE).

Harnessing coal and coal waste for environmental conservation: A review of photocatalytic materials.

Fossil fuels, especially coal, have played a pivotal role in driving technological and economic advancements over the past century, though accompanied by numerous environmental challenges. Rapid progress in green and sustainable energy sources, including tidal, wind, and solar energy, coupled with growing environmental concerns, the conventional coal industry is experiencing a sustained decline in both size and financial viability. This situation necessitates the urgent adoption of advanced approaches to coal utilization.

Effects of Heat Treatment on the Electromagnetic Wave Absorption Characteristics of Resorcinol Formaldehyde Silicon Dioxide Ceramic Particles.

In light of the pressing environmental and health issues stemming from electromagnetic pollution, advanced electromagnetic wave absorbing materials are urgently sought to solve these problems. The present study delved into the fabrication of the resorcinol formaldehyde (RF)/SiO ceramic particles using the sol-gel route. From SEM images and XRD and XPS analysis, it can be seen that the RF/SiO ceramic particles are successfully generated after heat treatment at 1500 °C.

Association of low muscle mass index and sarcopenic obesity with knee osteoarthritis: a systematic review and meta-analysis.

Background: Sarcopenia and knee osteoarthritis are common age-related diseases that have become important public health issues worldwide. Few studies have reported the association between muscle mass loss and knee osteoarthritis. This may be due to the high level of heterogeneity between studies stemming from different definitions of muscle mass loss.

Preparation of a Lignin-Based Cationic Flocculant and Its Application in Kaolin Suspension Treatment.

The preparation of an environmentally friendly and efficient flocculant for solid-liquid separation in industrial wastewater is highly important. In this study, a novel cationic flocculant (AL-g-PAMA) was synthesized by a thermal initiation method using alkali lignin (AL) as the main chain and acrylamide (AM) and methacrylamido propyl trimethyl ammonium chloride (MAPTAC) as the grafted side chains. The structure, thermal stability, and surface morphology of the copolymers were investigated by various characterization methods.

Amelioration of NAFLD by sleeve gastrectomy-triggered hepatocyte regeneration in mice - experimental research.

Background: Sleeve gastrectomy (SG) is known to alleviate non-alcoholic fatty liver disease (NAFLD) and restore liver function; however, its underlying mechanism remains unclear.

Materials And Methods: We investigated the effect of SG on the metabolic phenotype of diet-induced obese (DIO) mice. Postoperative stained liver images were analyzed to determine the hepatocyte proliferation phenotype.

The E3 ligase TRIM7 suppresses the tumorigenesis of gastric cancer by targeting SLC7A11.

Tripartite motif-containing protein 7 (TRIM7), as an E3 ligase, plays an important regulatory role in various physiological and pathological processes. However, the role of TRIM7 in gastric cancer (GC) is still undefined. Our study detected the expression of TRIM7 in clinical specimens and investigated the regulatory effect and molecular mechanism of TRIM7 on GC progression through in vitro and in vivo experiments.

Structure of a unique PSII-Pcb tetrameric megacomplex in a chlorophyll -containing cyanobacterium.

is a unique cyanobacterium using chlorophyll (Chl ) as its major pigment and thus can use far-red light for photosynthesis. Photosystem II (PSII) of associates with a number of prochlorophyte Chl-binding (Pcb) proteins to act as the light-harvesting system. We report here the cryo-electron microscopic structure of a PSII-Pcb megacomplex from at a 3.

Study on preparation of UV-CDs/Zeolite-4A/TiO composite photocatalyst coupled with ultraviolet-irradiation and their application of photocatalytic degradation of dyes.

In this work, ultraviolet irradiation was employed to assist in the preparation of a novel photocatalyst composite in the form of carbon dots/zeolite-4A/TiO, using coal tailings as the source of silicon-aluminum and carbon. The composite was designed for the degradation of methylene blue under 500 W of UV light irradiation. Zeolite-4A was used as a support for the well-dispersed carbon dots and TiO nanoparticles.

Construction of Hollow Ultrasmall CoO Nanoparticles Immobilized in BN for CO Conversion.

Rational design and fabrication of metal-organic framework-derived metal oxide (MO) materials featuring a hollow structure and active support can significantly enhance their catalytic activity for specific reactions. Herein, a series of CoO nanoparticles (NPs) immobilized in boron nitride (denoted as CoO@BN) with highly open and precisely controllable structures were constructed by an in situ self-assembly method combined with a controlled annealing process. The obtained CoO@BN not only possesses a hollow structure but also shows highly dispersed CoO NPs and high loadings of up to 34.

Collagen Scaffolds Functionalized by Cu-Chelated EGCG Nanoparticles with Anti-Inflammatory, Anti-Oxidation, Vascularization, and Anti-Bacterial Activities for Accelerating Wound Healing.

Skin injury is a common health problem worldwide, and the highly complex healing process poses critical challenges for its management. Therefore, wound dressings with salutary effects are urgently needed for wound care. However, traditional wound dressing with a single function often fails to meet the needs of wound repair, and the integration of multiple functions has been required for wound repair.