Successful pregnancy via in vitro fertilization in a primary infertile woman with primary lymphoma of the fallopian tube after surgery: A case report and literature review.

Rationale: Primary extranodal marginal zone B-cell lymphomas of the fallopian tube is extremely rare. It is a great challenge for fertility and gynecology doctors to manage such cases and also fulfil the reproductive demands of these young women.

Patient Concerns: A 30-year-old woman consulted for a 5-year primary infertility.

A retrospective study on IVF/ICSI outcomes in patients with persisted positive of anticardiolipin antibody: Effects of low-dose aspirin plus low molecular weight heparin adjuvant treatment.

Antiphospholipid (aPL) antibodies are more frequently detected among infertile women, but the association between aPL and in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) outcomes and whether need to get routine treatment are still controversial. The present study aims to find out whether infertile population with persistent aPL positive need treatment and which therapy is more effective. This retrospective study included 181 persistent aPL positive women, including 149 cases receiving anticoagulant treatment, either low-dose aspirin, low molecular weight heparin (LMWH) or aspirin plus LMWH adjuvant treatment (treated group), and 32 cases not receiving any treatment (untreated group).

Discovery of Polythioplatinate(II) [PtS(SO)] and Study of Its Solution and Catalytic Properties.

We have discovered the first polythioplatinate(II), [PtS(SO)] (), which was synthesized in aqueous basic medium (pH 11) by hydrothermal heating at 150 °C. Polyanion comprises a discrete, triangular assembly of three Pt ions linked by two μ-sulfido ligands, and their square-planar coordination geometry is completed by two terminal S-bound sulfito ligands. Polyanion was isolated as a hydrated sodium salt, Na[Pt(μ-S)(SO)]·22HO (), which was characterized in the solid state by single-crystal X-ray diffraction, Fourier-transform infrared spectroscopy, thermogravimetric analysis, X-ray photoelectron spectra, and elemental analysis, in solution by Pt NMR and atomic absorption spectroscopy, and in the gas phase by electrospray ionization mass spectrometry.

Glaucoma in rural China (the Rural Epidemiology for Glaucoma in China (REG-China)): a national cross-sectional study.

Objective: This study aimed to investigate the prevalence of glaucoma with associated factors in the rural populations of 10 provinces in China.

Design: A population-based cross-sectional study.

Methods: All participants aged 6 years or older from 10 provinces completed visual acuity testing, slit-lamp examination, ophthalmoscopy and non-contact tonometry.

Antifungal activity of montmorillonite/peptide aptamer nanocomposite against Colletotrichum gloeosporioides on Stylosanthes.

Chemical agents are effective treatment methods for anthracnose induced by pathogenic Colletotrichum gloeosporioides on Stylosanthes. However, excess consumption of chemical agents destroys the environment, synthetic biology was capable of conquering the issue. The antifungal agent is developed by enclosing a bio-synthesized peptide aptamer with layered montmorillonite via electrostatic interaction.

Organically Functionalized Mixed-Valent Polyoxo-30-molybdate Wheel and Neutral Tetramolybdenum(V) Oxo Cluster.

The first organofunctionalized mixed-valent polyoxo-30-molybdate wheel, [MoMoO{AsO(CH)}] (), was synthesized in aqueous, mildly acidic conditions, and upon further acidification, the neutral tetramolybdenum(V) oxo cluster [MoO{AsO(CH)}] () was obtained. Single-crystal X-ray diffraction (XRD) revealed that comprises 18 Mo and 12 Mo ions arranged in a cyclic fashion with alternating {Mo} and {Mo} groups, which are capped by 18 dimethylarsinate ligands, resulting in a novel polyoxo-30-molybdate wheel with a central cavity of ∼1.5 nm.

Melatonin protects against maternal diabetes-associated meiotic defects by maintaining mitochondrial function.

Maternal diabetes has been widely reported to adversely affect oocyte quality. Although various molecules and pathways may be involved in this process, strategies to prevent maternal diabetes-induced deterioration of oocyte quality remain unexplored. Melatonin is synthesized by the pineal gland and has been shown to have beneficial effects on oocyte quality owing to its antioxidative function.

Metformin inhibits melanoma cell metastasis by suppressing the miR-5100/SPINK5/STAT3 axis.

Melanoma is the most lethal skin cancer characterized by its high metastatic potential. It is urgent to find novel therapy strategies to overcome this feature. Metformin has been confirmed to suppress invasion and migration of various types of cancer.

Discrete Arsonate-Grafted Inverted-Keggin 12-Molybdate Ion [MoO(OH)(4-NCH-CHAsO)] and Formation of a Copper(II)-Mediated Metal-Organic Framework.

The discrete inverted-Keggin ion [MoO(OH)(4-NCH-CHAsO)] () has been prepared in an aqueous acidic (pH 0.8) medium by the reaction of MoO with the (4-triazolylphenyl)arsonic acid 4-NCH-CHAsOH under hydrothermal conditions and was isolated as a sodium salt in 21% yield. The exact same reaction in the presence of Cu ions resulted in the neutral metal-organic framework (MOF) Cu[MoO(4-NCH-CHAsO)] () in 68% yield.

Reversible Multilevel Stimuli-Responsiveness and Multicolor Room-Temperature Phosphorescence Emission Based on a Single-Component System.

There are limited reports about the transformation of pure organic room-temperature phosphorescence (RTP) materials with multilevel stimuli-responsiveness at different RTP emission wavelengths under external stimuli. It is difficult to ensure efficient intersystem crossing (ISC) in different states of a single-component system. This research reports the conversion of the organic single-component small molecule 1,2-bis(4-alkoxyphenyl)ethane-1,2-dione (N-BOX) with multilevel stimuli-responsiveness between high-efficiency blue and yellow RTP by grinding or thermal annealing N-BOX crystals.

Development of a prognostic nomogram for metastatic pancreatic ductal adenocarcinoma integrating marital status.

Previous studies have shown that marital status can affect the overall survival (OS) of cancer patients yet its role in metastatic pancreatic ductal adenocarcinoma (mPDAC) remains unclear. This study aimed to explore the impact of marital status on the OS of mPDAC patients and to construct a prognostic nomogram to predict OS outcomes. Data from patients diagnosed with mPDAC were obtained from the Surveillance, Epidemiology, and End Results database between 1973 and 2015.

Fibrillin-1 Gene Polymorphisms (rs145233125, rs11070646, rs201170905) Are Associated With the Susceptibility and Clinical Prognosis of DeBakey Type III Aortic Dissection in Chinese Han Population.

We aim to investigate whether genetic variants of the Fibrillin-1 (FBN1) gene were associated with DeBakey type III aortic dissection (AD) and its clinical prognosis in Chinese Han population. Three single-nucleotide polymorphisms (SNPs) (rs145233125, rs11070646, rs201170905) in FBN1 were analyzed in patients with DeBakey type III AD (159) and healthy subjects (216). Gene-environment interactions were evaluated to use generalized multifactor dimensionality reduction.

NOL6 Regulates the Proliferation and Apoptosis of Gastric Cancer Cells Regulating TP53I3, CDK4 and MCM7 Expression.

Background: Gastric cancer (GC) is a prevalent cancer with high mortality and strong invasiveness, and the entire regulatory networks of GC is still unclear.

Objective: The aim of this study was to explore the specific mechanism of the effect of nucleolar protein 6 (NOL6) on the proliferation and apoptosis of GC cells.

Methods: The human gastric adenocarcinoma cell line HGC-27 and AGS were cultured.

Design, synthesis, and molecular docking studies of novel pomalidomide-based PROTACs as potential anti-cancer agents targeting EGFR and EGFR.

A new class of EGFR PROTACs based on pomalidomide was developed, synthesised, and tested for their cytotoxic activity against a panel of human cancer cells. Compounds - were showed to be more effective against the four tested cell lines than erlotinib. In particular, compound was found to be the most potent counterpart as it was 5.

TSPAN31 regulates the proliferation, migration, and apoptosis of gastric cancer cells through the METTL1/CCT2 pathway.

Gastric cancer (GC) is one of the most common human malignancies worldwide, but the molecular mechanism of GC has not been fully elucidated. Tetraspanin 31 (TSPAN31) has been rarely studied in human malignant tumors. This study aimed to investigate the effects of TSPAN31 on GC.

A Clinical Practice Guideline for the Emergency Management of Anaphylaxis (2020).

For anaphylaxis, a life-threatening allergic reaction, the incidence rate was presented to have increased from the beginning of the 21st century. Underdiagnosis and undertreatment of anaphylaxis are public health concerns. This guideline aimed to provide high-quality and evidence-based recommendations for the emergency management of anaphylaxis.

Correlation of MIF-AS1 polymorphisms with the risk and prognosis of gastric cancer.

Background: The most studied genetic polymorphisms associated with gastric cancer (GC) risk are located in protein-coding genes. However, the localization of these in long non-coding RNAs (lncRNAs) has not been fully studied. We aim to investigate the associations of Long non-coding RNA macrophage migration inhibitory factor antisense RNA1(Lnc-MIF-AS1) five polymorphisms (rs755622, rs17004044, rs2070767, rs1007889, rs2000468) with the risk and prognosis of GC.

Correlation between betatrophin/angiogenin-likeprotein3/lipoprotein lipase pathway and severity of coronary artery disease in Kazakh patients with coronary heart disease.

Background: The results of previous animal experiments and clinical studies have shown that there is a correlation between expression of betatrophin and blood lipid levels. However, there are still differences studies on the correlation and interaction mechanism between betatrophin, angiogenin-likeprotein3 (ANGPTL3) and lipoprotein lipase (LPL). In our previous studies, we found an increase in serum ANGPTL3 Levels in Chinese patients with coronary heart disease (CHD).

Association of gene polymorphisms in FBN1 and TGF-β signaling with the susceptibility and prognostic outcomes of Stanford type B aortic dissection.

Background: This study is aimed at investigating the association of Fibrillin-1 (FBN1) and transforming growth factor β (TGF-β) signaling-related gene polymorphisms with the susceptibility of Stanford type B aortic dissection (AD) and its clinical prognostic outcomes.

Methods: Five single-nucleotide polymorphism (SNPs) (FBN1rs 145233125, rs201170905, rs11070646, TGFB1rs1800469, and TGFB2rs900) were analyzed in patients with Stanford type B AD (164) and healthy controls (317). Gene-gene and gene-environment interactions were assessed by generalized multifactor dimensionality reduction.

Synthesis of a new bifunctional NODA for bioconjugation with PSMA ligand and one-step AlF labeling.

The AlF labeling method is a relatively new approach that allows radiofluorination of biomolecules such as peptides and proteins in a one-step procedure and in an aqueous solution. However, instability of the complex of [AlF] with hexadentate chelator NOTA may attribute to the disassociation of free F and [AlF] and accumulation in bone. In this study, we designed and synthesized a new bifunctional pentadentate AlF-chelator p-SCN-PhPr-NODA as well as its nitro form p-NO-PhPr-NODA.

The interplay of environmental luminance and genetics in the retinal dystrophy induced by the dominant RPE65 mutation.

SignificanceIn humans, genetic mutations in the retinal pigment epithelium (RPE) 65 are associated with blinding diseases, for which there is no effective therapy alleviating progressive retinal degeneration in affected patients. Our findings uncovered that the increased free opsin caused by enhancing the ambient light intensity increased retinal activation, and when compounded with the RPE visual cycle dysfunction caused by the heterozygous D477G mutation and aggregation, led to the onset of retinal degeneration.

Associations of Dietary Inflammatory Index With Prediabetes and Insulin Resistance.

Background And Aims: Previous studies suggested that dietary inflammatory index (DII) was associated with a variety of adverse health conditions. However, less is known about the role of DII in prediabetes and insulin resistance (IR). Therefore, this study aimed to investigate whether DII is associated with prediabetes and IR in American adults.

[Problems and countermeasures of soil health quality in urban green space].

Soil quality of urban green space (UGS) is the basis for ensuring healthy growth of plants and maintaining the healthy ecosystem services for the residents and the sustainable development of city. At present, in order to improve the soil quality of UGS, more attention has been paid to fertility quality and environmental quality, but less to the health quality. We analyzed the concept, connotation, and assessment indicator of soil health quality, summarized the main problems and challenges of soil health quality of UGS.