Luteolin modulates macrophage phenotypic switching via the AMPK-PPARγ pathway to alleviate ulcerative colitis in mice.

Ethnopharmacological Relevance: Lonicerae japonicae flos (LJF), the dried flower bud or newly bloomed flower of Lonicera japonica Thunb., is widely used in Traditional Chinese medicine (TCM), exhibiting anti-inflammatory and immune-enhancing properties. Luteolin (Lut) is a major bioactive component of LJF, demonstrating a regulatory role in immune disorders.

Bta-miR-484 regulates proliferation and apoptosis of bovine intramuscular preadipocytes via targeting MAP3K9 to inhibit the JNK signaling pathway.

Intramuscular fat (IMF) plays a crucial role in enhancing the tenderness, flavor, and juiciness of beef, making the increase of IMF content a significant objective in beef breeding. A key factor influencing IMF levels is the number of intramuscular preadipocytes. Previous studies have indicated a correlation between bta-miR-484 and IMF content.

The impacts of climate change on the potential distribution of Cacopsylla chinensis (Hemiptera: Psyllidae) in China.

Cacopsylla chinensis is an oligophagous pest and has become one of the main pests that cause yield loss in commercial pear orchards in China. Predicting the impact of climate change on the distribution range of C. chinensis is crucial for its effectively preventing and managing.

Restoration of submerged vegetation modulates microbial communities to decrease nitrogen and phosphorus loads in sediment-water systems.

The release of nitrogen and phosphorus from sediments, known as internal nutrient loading, plays a crucial role in determining the eutrophic state of lakes and the timeframe for their ecological recovery. The restoration of submerged macrophytes is considered an effective measure to improve lake eutrophication. However, the impact of submerged macrophytes restoration on the storage and transformation mechanisms of nitrogen and phosphorus in lake sediment-water systems has not yet been systematically studied.

Targeting the NOTCH2/ADAM10/TCF7L2 Axis-Mediated Transcriptional Regulation of Wnt Pathway Suppresses Tumor Growth and Enhances Chemosensitivity in Colorectal Cancer.

Wnt/β-catenin/transcription factor (TCF) transcriptional activity plays an integral role in colorectal cancer (CRC) carcinogenesis. However, to date, no drugs targeting this pathway are used in clinical practice owing to the undesirable and serious side effects. In this study, it is found that the transcriptional regulation of Wnt pathway is activated and associated with liver metastasis in CRC.

Depression and the risk of fibromyalgia syndrome: a two-sample Mendelian randomization study.

Background: Fibromyalgia (FM) is a common illness with a wide range of symptoms, mainly manifested by unexplained chronic systemic musculoskeletal pain, sleep disorders and fatigue, sometimes accompanied by cognitive impairment, psychiatric symptoms and autonomic dysfunction. Previous studies have indicated a correlation between depression and the risk of FM; however, it remains uncertain whether this association reflects a causal relationship.

Methods: We evaluated the etiological association between the genetically predicted depression and the risk of developing FM by conducting a two-sample Mendelian Randomization (MR) study.

Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency.

Antibody drugs targeting single inflammatory cytokines have revolutionized the treatment of immune-mediated inflammatory diseases. To investigate whether dual targeting interleukin-17 (IL-17) and IL-36 enhances anti-inflammatory activity, bispecific Ab HB0043 was generated by linking the single chain fragment variables (scFvs) from humanized anti-IL-36R antibody (HB0034) to the C-terminus of the heavy chain of anti-IL-17A IgG1 (HB0017) Fc using a flexible peptide linker. HB0043 largely maintained the binding affinities and biological activities of the two parent monoclonal antibodies (mAbs) .

STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma.

Clear cell renal cell carcinoma (ccRCC) is a prevalent malignant tumor of the urinary system. While tyrosine kinase inhibitors (TKIs) are currently the first-line treatments for advanced/metastatic ccRCC, patients often develop resistance after TKI therapy. Lipid metabolic reprogramming, a hallmark of tumor progression, contributes to acquired drug resistance in various malignant tumors.

Conductive Porous Solid Framework Mechanically Stabilized Si Anode.

Micron-sized Si anodes garner renewed attention due to their advantages of low cost, small specific surface area, and high energy density. However, micron-sized Si anodes undergo significant volume changes during lithiation/delithiation, leading to particle cracking and pulverization. This study employs the tape casting method and ultrafast high-temperature sintering technology to construct a porous sheet, within which a solid framework constrains the Si particles.

Identification and Characterization of Linear Epitopes of Monoclonal Antibodies Against African Horse Sickness Virus Serotype 1 VP2 Protein.

African horse sickness (AHS) is an acute, fatal, contagious disease of animals of the family Equidae and is caused by infection with the African horse sickness virus (AHSV). Based on the outer capsid protein VP2, AHSV is classified into nine serotypes (AHSV-1 to -9) with little or no serological cross-reactivity between them. In 2020, AHS outbreaks caused by AHSV-1 were reported in Thailand and Malaysia, marking the first occurrences of AHS in Southeast Asia.

and Alleviate High-Fat Diet-Induced Obesity and Depression/Cognitive Impairment-like Behavior in Mice by Upregulating AMPK Activation and Downregulating Adipogenesis and Gut Dysbiosis.

Long-term intake of a high-fat diet (HFD) leads to obesity and gut dysbiosis. AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism. Herein, we investigated the impacts of P111 and P121, which suppressed dexamethasone-induced adipogenesis in 3T3 L1 cells and increased lipopolysaccharide-suppressed AMPK activation in HepG2 cells, on HFD-induced obesity, liver steatosis, gut inflammation and dysbiosis, and depression/cognitive impairment (DCi)-like behavior in mice.

Comparative Study on the Prevention and Control Effects of Rockburst Between Hydraulic Fracturing Sections and Blank Sections.

Influenced by various factors such as the complex environment and high key layers in coal mines, hydraulic fracturing technology has gradually become the main means of controlling the hard roof strata to prevent and control rockburst in recent years, which can effectively release the stress on the roof, reduce the intensity of pressure, and ensure the safe and efficient mining of the working face in coal mines. However, the current research on hydraulic fracturing to prevent and control rockburst is mostly limited to optimizing fracturing parameters and monitoring and evaluating fracturing effects, and there are few studies on blank sections, which cannot guarantee the overall prevention and control effect of rockburst, or increase unnecessary construction costs. In this paper, for the directional long borehole staged hydraulic fracturing project, triangular-type blank sections and regular-type blank sections are defined, and the rockburst prevention and control effects of fracturing sections and triangular-type blank sections during fracturing are compared and analyzed by the underground-ground integrated microseismic monitoring technology and transient electromagnetic detection technology, and the rockburst prevention and control effects of fracturing sections and regular-type blank sections during the coal extraction period are compared and analyzed by the underground-ground integrated microseismic monitoring data such as microseismic energy level and frequency as well as the online stress monitoring data.

Therapeutic Potential of Insect Defensin DLP4 Against -Infected Piglet Exudative Epidermitis.

: The emergence of resistance to (), the major cause of exudative epidermatitis (EE) in piglets, has led to the need for new antimicrobial agents. The study aimed to evaluate the potential efficacy of the insect defensin DLP4 against EE in piglets caused by clinically isolated ACCC 61734. : DLP4 showed strong antibacterial activity against ACCC 61734 (minimum inhibitory concentration, MIC: 0.

Whole Genome Sequencing and Biocontrol Potential of ASG80 Against Diseases.

-induced crop diseases, commonly known as "plant plagues", pose a significant threat to global food security. In this study, strain ASG80 was isolated from sisal roots and demonstrated a broad-spectrum antagonistic activity against several species and fungal pathogens. Strain ASG80 was identified as via phylogenetic analysis, digital DNA-DNA hybridization (dDDH), and average nucleotide identity (ANI).

Prickly Ash Seeds Improve the Ruminal Epithelial Development and Growth Performance of Hu Sheep by Modulating the Rumen Microbiota and Metabolome.

It is known that the addition of feed rich in bioactive components to animal diets will affect rumen fermentation parameters and flora structure. However, research on the regulatory effects of prickly ash seeds (PASs) during rumen development or on the rumen microbiome and its metabolites in sheep is limited. The current study was designed to explore the effects of PASs on sheep rumen development and growth performance using metagenomics and metabolomics.

Construction of a MoO/MoS Heterojunction via the Surface Sulfurization of the Oxide and Its Photocurrent-Switching Characteristics in the Range of the Broadband Light Spectrum.

In order to utilize the longer wavelength light, the surface sulfurization of MoO was carried out. The photocurrent responses to typical 650, 808, 980, and 1064 nm light sources with Au gap electrodes were investigated. The results showed that the surface S-O exchange of MoO improved the interfacial charge transfer in the range of the broadband light spectrum.

A Highly Sensitive Strain Sensor with Self-Assembled MXene/Multi-Walled Carbon Nanotube Sliding Networks for Gesture Recognition.

Flexible electronics is pursuing a new generation of electronic skin and human-computer interaction. However, effectively detecting large dynamic ranges and highly sensitive human movements remains a challenge. In this study, flexible strain sensors with a self-assembled PDMS/MXene/MWCNT structure are fabricated, in which MXene particles are wrapped and bridged by dense MWCNTs, forming complex sliding conductive networks.

Resistance Exercise Improves Glycolipid Metabolism and Mitochondrial Biogenesis in Skeletal Muscle of T2DM Mice via miR-30d-5p/SIRT1/PGC-1α Axis.

Exercise is a recognized non-pharmacological treatment for improving glucose homeostasis in type 2 diabetes (T2DM), with resistance exercise (RE) showing promising results. However, the mechanism of RE improving T2DM has not been clarified. This study aims to investigate the effects of RE on glucose and lipid metabolism, insulin signaling, and mitochondrial function in T2DM mice, with a focus on the regulatory role of miR-30d-5p.