STMGraph: spatial-context-aware of transcriptomes via a dual-remasked dynamic graph attention model.

Spatial transcriptomics (ST) technologies enable dissecting the tissue architecture in spatial context. To perceive the global contextual information of gene expression patterns in tissue, the spatial dependence of cells must be fully considered by integrating both local and non-local features by means of spatial-context-aware. However, the current ST integration algorithm ignores for ST dropouts, which impedes the spatial-aware of ST features, resulting in challenges in the accuracy and robustness of microenvironmental heterogeneity detecting, spatial domain clustering, and batch-effects correction.

Characterization of 3,3'-iminodipropionitrile (IDPN) damaged utricle transcriptome in the adult mouse utricle.

Utricle is an important vestibular sensory organ for maintaining balance. 3,3'-iminodipropionitrile (IDPN), a prototype nitrile toxin, has been reported to be neurotoxic and vestibulotoxic, and can be used to establish an damage model of vestibular dysfunction. However, the mechanism of utricular HCs damage caused by IDPN is unclear.

Diagnostic Accuracy of FEF for Bronchial Hyperresponsiveness in Patients with Suspected Asthma and/or Allergic Rhinitis: A Systematic Review and Meta-analysis.

Background: Some studies have suggested that the forced expiratory flow between 25 and 75% of vital capacity (FEF) can be used as an early marker of bronchial hyperresponsiveness (BHR) in asthma and allergic rhinitis (AR), but is highly variable. Here, we aimed to assess whether the FEF can be used to diagnose BHR in patients with asthma-like symptoms and AR.

Methods: PubMed, EMBASE, Web of Science, Wiley Online Library, Cochrane Library, SinoMed, CNKI, and Wanfang Data were searched to acquire eligible studies.

Causal genes identification of giant cell arteritis in CD4+ Memory t cells: an integration of multi-omics and expression quantitative trait locus analysis.

Background: Giant cell arteritis (GCA) is a prevalent artery and is strongly correlated with age. The role of CD4+ Memory T cells in giant cell arteritis has not been elucidated.

Method: Through single-cell analysis, we focused on the CD4+ Memory T cells in giant cell arteritis.

Innovative Mechanical Processing of Adipose Tissue: A Comparative Evaluation of Microfat and Concentrated Micronized Fat for Superficial Fat Grafting.

Background: Superficial autologous fat grafting is widely used for facial rejuvenation and regenerative treatments, yet its retention rate remains unpredictable. Enhancing the concentration of adipose-derived stem cells (ASCs) has been shown to improve graft retention. Mechanical fat processing techniques can reduce fat granules size for superficial injection as well as elevate the concentration of ASCs.

GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy.

Background: Immunotherapy that targets immune checkpoints has achieved revolutionary success, but its application in solid tumors remains limited, highlighting the need for reliable enhancement of the efficacy of immunotherapy. Golgi protein 73 (GP73), a Golgi membrane protein, has been implicated in various cellular processes, including immune regulation. Recent studies suggested that GP73 may play a role in modulating the immune response in patients with cancer.

Adipose ZFP36 protects against diet-induced obesity and insulin resistance.

Aims: Obesity, as a worldwide healthcare problem, has become more prevalent. ZFP36 is a well-known RNA-binding protein and involved in the posttranscriptional regulation of many physiological processes. Whether the adipose ZFP36 plays a role in obesity and insulin resistance remains unclear.

Sustainable aviation fuel (SAF) from lignin: Pathways, catalysts, and challenges.

The aviation industry plays a crucial role in global trade and cultural exchange, but it faces significant challenges due to high fuel costs and environmental impacts. To achieve carbon neutrality, promoting the development of sustainable aviation fuel (SAF) is essential, with projections indicating that 65% of emissions reductions in the aviation industry by 2050 will come from the use of SAF. Lignin, as an abundant renewable resource, has great potential for conversion into aviation fuel components.

Dispersive gains enhance wireless power transfer with asymmetric resonance.

Parity-time symmetry is a fundamental concept in non-Hermitian physics that has recently gained attention for its potential in engineering advanced electronic systems and achieving robust wireless power transfer even in the presence of disturbances, through the incorporation of nonlinearity. However, the current parity-time-symmetric scheme falls short of achieving the theoretical maximum efficiency of wireless power transfer and faces challenges when applied to non-resistive loads. In this study, we propose a theoretical framework and provide experimental evidence demonstrating that asymmetric resonance, based on dispersive gain, can greatly enhance the efficiency of wireless power transfer beyond the limits of symmetric approaches.

Highly Elastic Spongelike Hydrogels for Impedance-Based Multimodal Sensing.

Hydrogel-based sensors have been widely studied for perceiving the environment. However, the simplest type of resistive sensors still lacks sensitivity to localized strain and other extractable data. Enhancing their sensitivity and expanding their functionality to perceive multiple stimuli simultaneously are highly beneficial yet require optimal material design and proper testing methods.

Rapidly self-crosslinking sodium alginate hydrogel for infected wounds.

The risks associated with wound infections are significant, making a snug-fitting hydrogel dressing an optimal choice for wound management. For it, we employed the self-cross-linking method of oxidized sodium alginate (SCSA), incorporating clarithromycin (Cla) and basic fibroblast growth factor (bFGF) to formulate a rapidly forming, bacteriostatic, and wound-healing hydrogel (SCSA@C/b). Bacteriostatic and cytocompatibility assays demonstrated that SCSA@C/b exhibits exceptional antibacterial activity alongside strong biocompatibility.

Corrigendum: Characterization of expression in mouse cochlear hair cells.

[This corrects the article DOI: 10.3389/fgene.2021.

Plasma-based transcriptomic non-coding signature for predicting relapse in pediatric acute lymphoblastic leukemia.

Pediatric Acute Lymphoblastic Leukemia (ALL) is the most common malignant tumor of the hematological system in children, and its relapse after treatment has consistently been a significant factor hindering prognosis. This study aimed to develop a blood-based non-invasive method for predicting relapse in children with ALL. Two cohorts of pediatric ALL patients were analyzed.

Epidemiological insights into severe hepatitis in pediatric inpatients.

There is limited statistical data on severe hepatitis among hospitalized children in China at a national level. This nationwide study analyzed data from 34,410 children hospitalized for severe hepatitis in mainland China from 2016 to 2022. The overall in-hospital mortality rate was 6.

Google Trends applications for COVID-19 pandemic: A bibliometric analysis.

Introduction: COVID-19 is one of the most severe global health events in recent years. Google Trends provides a comprehensive analysis of the search frequency for specific terms on Google, reflecting the public's areas of interest. As of now, there has been no bibliometric study on COVID-19 and Google Trends.

Ordered Photoexfoliation for Polypseudorotaxane Nanosheets.

Two-dimensional layered structural materials exhibit a wide range of properties due to their ultrahigh specific surface area. However, achieving ordered exfoliation to obtain uniform two-dimensional structures remains challenging. In this study, we developed a supramolecular system by covalently bonding hexathiobenzene (HB) into β-cyclodextrin to create a light-responsive moiety, followed by coassembly with bipyridine and nickel ions to form a polypseudorotaxane (PR) system, which enables an light-induced exfoliation strategy for two-dimensional materials.

Ginsenoside Rg1: A bioactive therapeutic agent for diverse liver diseases.

Diverse liver diseases are characterised by late diagnosis and rapid progression and have become one of the major threats to human health. To delay the transition from benign tissue lesions to a substantial organ injury, scientists have gradually applied natural compounds derived from plants as a complementary therapy in the field of hepatology. Ginseng (Panax ginseng C.

Isolation optimization and screening of halophilic enzymes and antimicrobial activities of halophilic archaea from the high-altitude, hypersaline Da Qaidam Salt lake, China.

Aim: The aim of this study is to increase the diversity of culturable halophilic archaea by comparing various isolation conditions and to explore the application of halophilic archaea for enzyme-producing activities and antimicrobial properties.

Methods And Results: We systematically compared the isolation performance of various archaeal and bacterial media by isolating halophilic archaea from the Da Qaidam Salt Lake, a magnesium sulfate subtype hypersaline lake on the Qinghai-Tibet Plateau, China, using multiple enrichment culture and gradient dilution conditions. A total of 490 strains of halophilic archaea were isolated, which belonged to five families and 11 genera within the order Halobacteriales of the class Halobacteria of the phylum Euryarchaeota.

Rapid identification of horse oil adulteration based on deep learning infrared spectroscopy detection method.

As a natural oil, horse oil has unique biological activity ingredients and therapeutic characteristics, which has important application value and market potential in healthcare, food, skin care and other fields. However, fraud is rampant in the horse oil market, and traditional methods such as chemical analysis and physical property detection are time-consuming, costly, and have low accuracy in detecting adulteration. Excessive adulteration may cause health risks, skin problems, and economic losses.

PBVD regimen (pegylated liposomal doxorubicin, bleomycin, vincristine, dacarbazine) in classical Hodgkin lymphoma patients with cardiovascular risk factors: a retrospective study.

This retrospective study aimed to evaluate the efficacy and safety of PBVD (pegylated liposomal doxorubicin [PLD], bleomycin, vinblastine, and dacarbazine) in the first-line treatment of classical Hodgkin lymphoma (cHL) patients with cardiovascular risk factors. Overall, 84 patients (53 had stage I-II and 31 had stage III-IV disease) received PBVD. The median PLD treatment duration was 16 weeks (interquartile range [IQR]: 8-24) for stage I-II and 24 weeks (IQR: 12-24) for stage III-IV.

Inflammatory markers predict efficacy of immunotherapy in advanced non-small cell lung cancer: a preliminary exploratory study.

Objective: The purpose of this study is to analyze the predictive value of neutrophil to lymphocyte ratio (NLR), lymphocyte count to monocyte count ratio (LMR), platelet to lymphocyte ratio (PLR), platelet count multiplied by neutrophil count to lymphocyte count ratio (SII), red blood cell distribution width (RDW), packed cell volume (PCV), and plateletcrit (PCT) levels in advanced non-small cell lung cancer (NSCLC) patients treated with PD-1/PD-L1 inhibitors.

Materials And Methods: From March 2019 to August 2023, we screened 104 of 153 patients with stage III unresectable local advanced NSCLC and IV NSCLC who received PD-1/PD-L1 inhibitor therapy at our hospital and met the inclusion and exclusion criteria for analysis. All patients were collected for clinical information, including baseline blood indicator (NLR, PLR, LMR, SII, CRP, RDW, PCV and PCT) levels before PD-1/PD-L1 inhibitor therapy and blood indicator levels and imaging evaluation results every two cycles after PD-1/PD-L1 inhibitor therapy.

Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study.

Background: The association between serum uric acid (SUA) and dyslipidaemia is still unclear in patients with type 2 diabetes mellitus (T2DM). This study aimed to examine the association between SUA and dyslipidaemia and to explore whether there is an optimal SUA level corresponding to the lower risk of suffering from dyslipidaemia.

Research Design And Methods: This cross-sectional study included 1036 inpatients with T2DM and the clinical data were extracted from the hospital medical records.

Chemodivergent, enantio- and regioselective couplings of alkynes, aldehydes and silanes enabled by nickel/N-heterocyclic carbene catalysis.

Divergent synthesis of valuable molecules through common starting materials and metal catalysis represents a longstanding challenge and a significant research goal. We here describe chemodivergent, highly enantio- and regioselective nickel-catalyzed reductive and dehydrogenative coupling reactions of alkynes, aldehydes, and silanes. A single chiral Ni-based catalyst is leveraged to directly prepare three distinct enantioenriched products (silyl-protected trisubstituted chiral allylic alcohols, oxasilacyclopentenes, and silicon-stereogenic oxasilacyclopentenes) in a single chemical operation.

Controlling mission hazards through integrated abort and spare support optimization.

This study explores the risk management challenges associated with safety-critical systems required to execute specific missions. The working component experiences degradation governed by a continuous-time discrete-state Markov chain, whose failure leads to an immediate system breakdown and safety losses. To enhance system survivability, a limited number of identical spares are available for online replacement throughout the mission.