The myb transcription factor PtoPHL3 positively regulates poplar resistance to canker disease caused by Dothiorella gregaria.

Diseases caused by pathogenic microorganisms impair plant growth, leading to reduced crop yields. While the molecular mechanisms of plant disease response are well understood in annual herbaceous species, they remain largely unknown in perennial woody plants. Here, we found that PtoPHL3, a key transcription factor in poplar's phosphorus starvation response, showed significant expression changes after treatments with salicylic acid (SA) and methyl jasmonate (MeJA), and inoculation of Dothiorella gregaria that causes poplar canker disease.

Irisin and liraglutide combination therapy mitigates myocardial reperfusion injury in obese rats: Role of endoplasmic reticulum stress and apoptosis.

Background: Obesity has become a global health concern, with its prevalence steadily rising across populations. Apart from its well-known association with various metabolic disorders, obesity has also been linked to an increased risk of cardiovascular diseases, including myocardial ischemia-reperfusion (IR) injury. This study aimed to assess how irisin and liraglutide, when used together, impact endoplasmic reticulum (ER) stress-induced apoptosis and PI3K/AKT signaling in obese rats after cardiac IR injury.

[miR-207 targets autophagy-associated protein LAMP2 to regulate the mechanism of macrophage-mycobacterium tuberculosis interaction].

Objectives miR-207 has been identified as being expressed in natural killer (NK) cell exosomes that play a role in disease progression; however, to date, there are no studies specifically linking miR-207 to tuberculosis (TB). Methods Bioinformatics methods employed for prediction, followed by a dual luciferase reporter assay to determine whether lysosome-associated membrane protein 2 (LAMP2) is targeted by miR-207. The experiments were divided into four groups using the liposome transfection method (OP-LAMP2 group: co-transfected with miR-207 mimics and LAMP2 overexpression plasmid; EP group: co-transfected with mimics NC and null-loaded plasmid; siLAMP2 group: transfected with siLAMP2; and siLAMP2-NC group: transfected with siLAMP2-NC).

Association between neutrophil percentage-to-albumin ratio and mortality in Hemodialysis patients: insights from a prospective cohort study.

Background: The neutrophil percentage-to-albumin ratio (NPAR) emerges as a novel inflammation marker, demonstrating prognostic ability in a variety of cardiovascular diseases. However, its impact on mortality among patients undergoing maintenance hemodialysis (MHD) remains uncertain. Our research aims to determine whether NPAR is a reliable predictor of mortality in MHD patients.

Design of a Portable Biofeedback System for Monitoring Femoral Load During Partial Weight-Bearing Walking.

Patients with femoral fractures are typically advised to undergo partial weight-bearing (PWB) gait training during the postoperative rehabilitation period to facilitate bone healing and restore lower limb function. Various current portable biofeedback devices monitor ground reaction force (GRF) to assess the femoral loading of patients with fractures during PWB walking. However, due to the influence of muscle forces and the complexity of load transmission in the lower limbs, GRF may not accurately reflect the internal forces in the femur during walking.

Existence of in Tibetan Antelope ().

Introduction: is a conditional pathogen that parasitizes the intestines of vertebrates and has been detected in various wild animals. However, its infection rate in Tibetan antelopes has not been previously studied.

Methods: In this study, 503 fecal samples from Tibetan antelopes were analyzed to determine the prevalence and molecular characteristics of .

Threonine and tyrosine kinase promotes multiple myeloma progression by regulating regucalcin expression.

Multiple myeloma (MM) is a malignant proliferative disorder of plasma cells and remains an incurable disease. Threonine and tyrosine kinase (TTK) is a dual-specific protein kinase that targets serine/threonine and tyrosine residues for phosphorylation. Its elevated expression has been linked to unfavorable outcomes in several types of cancer.

Boosting CO photoreduction over perovskite quantum dots decorated with dispersed ruthenium nanoparticles.

High efficiency CO conversion materials are ideal for solar to carbon fuel conversion. Halide perovskite quantum dots (QDs) are highly desirable as catalysts and have been extensively investigated in the field of CO photoreduction. The major challenge lies in the severe charge recombination and the weak ability to activate CO.

Electrical stimulation attenuates muscle atrophy induced by brachial plexus injury via upregulating HO-1 expression in rats.

Background: In cases of global brachial plexus injury, long-term denervation results in severe muscle atrophy in the hand. This study was conducted to investigate the protective effect of electrical stimulation (ES) on denervated intrinsic forepaw muscle (IFM) induced by global brachial plexus avulsion (GBPA) in rats, and whether heme oxygenase-1 (HO-1) is involved in the effect of ES on denervated IFM atrophy.

Methods: We established a GBPA rat model and denervated IFM was electrically stimulated at different frequencies (2, 10 and 20 Hz).

In Situ Formation of WC/WC Heterostructures on N-Doped Carbon for Deep Oxidative Desulfurization of Fuel Oil.

A novel tungsten-based heterojunction nanocomposite material was developed for the efficient oxidative desulfurization (ODS) of fuel oil, enabling the production of low-sulfur fuel and a reduction in harmful SO emissions. In this material, the WC/WC heterojunction was uniformly immobilized on a porous nitrogen-doped carbon (NC) matrix structure through facile in situ pyrolysis of polyaniline-phosphotungstic acid (PANI/PTA) precursors. The resultant WC/WC@NC catalyst demonstrated remarkable desulfurization performance, achieving 100% removal of 4000 ppm dibenzothiophene (DBT) in just 15 min at 60 °C in the presence of 0.

Comparative analysis of clinical efficacy of unilateral biportal endoscopic and open transforaminal lumbar interbody fusion in the treatment of lumbar degenerative.

Objective: To study the clinical efficacy of unilateral biportal endoscopic lumbar interbody fusion (ULIF) and transforaminal lumbar interbody fusion (TLIF) in the treatment of lumbar degenerative diseases, and to compare perioperative indicators, radiological outcomes, and paraspinal muscle -atrophy resulting from these two different surgical methods.

Background: Transforaminal lumbar interbody fusion (TLIF) is widely acknowledged as an efficacious surgical modality for alleviating low back pain. In recent years, unilateral biportal endoscopic lumbar interbody fusion (ULIF) has gained increasing application.

The impact of apolipoprotein E, type ∊4 allele on Alzheimer's disease pathological biomarkers: a comprehensive post-mortem pilot-analysis.

The apolipoprotein E type ∊4 allele (ApoE4) is known as the strongest genetic risk factor for Alzheimer's Disease (AD). Meanwhile, many aspects of its impact on AD pathology remain underexplored. This study conducts a systematic data analysisof donor data from the Seattle Alzheimer's Disease Brain Cell Atlas.

Efficient radiative cooling based on spectral regulation and atmospheric water harvesting with sunflower design.

Inspired by the fog-collecting abilities of the Namib Desert beetle, researchers have developed wettability-engineered surfaces for fog collection. However, these approaches fall short in arid regions where fog is absent. To address these challenges, we developed a dual-sided structure based on radiative cooling.

Graph-Property Relationships for Complex Chiral Nanodendrimers.

Organic, polymeric, and inorganic nanomaterials with radially diverging dendritic segments are known for their optical, physical, chemical, and biological properties inaccessible for traditional spheroidal particles. However, a methodology to quantitatively link their complex architecture to measurable properties is difficult due to the characteristically large degree of disorder, which is essential for observed property sets. Here, we address this conceptual problem using dendrimer-shaped gold particles with distinct stochastic branching and intense chiroptical activity using graph theory (GT).

Age-specific over-the-top techniques for physeal sparing anterior cruciate ligament (ACL) reconstruction in skeletally immature patients: Current concepts for prepubescents to older adolescents.

Tailored surgical strategies for anterior cruciate ligament (ACL) reconstruction in skeletally immature patients are presented, emphasizing techniques to minimize growth plate damage and ensure stability. As ACL injuries in youth increase, delaying surgery can lead to joint damage and poor recovery outcomes. Using magnetic resonance imaging-based assessments of skeletal maturity, the authors propose the 'over-the-top (OTT)' approach with lateral tenodesis, adapted for three growth stages: prepubescents, young adolescents and older adolescents.

Multiomic Sequencing of Intermediate- to High-Risk Cutaneous Squamous Cell Carcinoma Identifies Critical Genes and Expression Patterns Associated with Disease and Poor Outcomes.

Cutaneous squamous cell carcinoma is one of the most common cancers in humans and kills as many people annually as melanoma. The understanding of the transcriptional changes with respect to high-risk clinical/histopathologic features and outcome is poor. In this study, we examine stage-matched, outcome-differentiated cutaneous squamous cell carcinoma using whole-exome and transcriptome sequencing.

OsCYP22 Interacts With OsCSN5 to Affect Rice Root Growth and Auxin Signalling.

Beyond structural support, plant root systems play crucial roles in the absorption of water and nutrients, fertiliser efficiency and crop yield. However, the molecular mechanism regulating root architecture in rice remains largely unknown. In this study, a short-root rice mutant was identified and named Oscyp22.

Current Characteristics of REBCO Tapes in 6-Slot TSTC-CICC Under Bending Conditions.

Embedding stacked HTS tapes into twisted slots is one design approach for constructing fusion conductors. This paper adopts a Cable-in-Conduit Conductor (CICC) structure, utilizing commercially REBCO coated conductors. The cable framework is made of copper and features six helically twisted slots filled with 2G HTS tapes.

Grazing Intensity Modifies Soil Microbial Diversity and Their Co-Occurrence Networks in an Alpine Steppe, Central Tibet.

Grazing intensity is one of the crucial anthropogenic activities on alpine grasslands. However, how grazing intensity affects soil microorganism diversities and their co-occurrence networks in alpine steppe remains uncertain. We carried out a controlled grazing experiment (null grazing, CK; moderate grazing, MG; and heavy grazing, HG) on a typical alpine steppe in the Lhasa River Basin, Central Tibet, China.

SNP rs9364554 Modulates Androgen Receptor Binding and Drug Response in Prostate Cancer.

(1) Background: Prostate cancer treatment efficacy is significantly influenced by androgen receptor (AR) signaling pathways. SLC22A3, a membrane transporter, has been linked to SNP rs9364554 risk loci for drug efficacy in prostate cancer. (2) Methods: We examined the location of SNP rs9364554 in the genome and utilized TCGA and other publicly available datasets to analyze the association of this SNP with transcription levels.

Novel Fast-Setting and Mechanically-Strong Calcium Phosphate Pulp-Capping Cement with Metformin Release to Enhance Dental Pulp Stem Cells.

Traditional pulp-capping materials like mineral trioxide aggregate (MTA) offer excellent biocompatibility and sealing, but limitations such as prolonged setting time, low bioactivity, and high costs persist. Metformin, with its potential in craniofacial regeneration, could enhance dentin synthesis by targeting pulp cells. This study aimed to: (1) develop a calcium phosphate cement with chitosan (CPCC) with improved physio-mechanical properties; (2) incorporate metformin (CPCC-Met) to assess release; and (3) evaluate human dental pulp stem cells (hDPSCs) response.

B7-H3 CAR-T cell therapy combined with irradiation is effective in targeting bulk and radiation-resistant chordoma cancer cells.

Background: Chordoma is a slow-growing, primary malignant bone tumor that arises from notochordal tissue in the midline of the axial skeleton. Surgical excision with negative margins is the mainstay of treatment, but high local recurrence rates are reported even with negative margins. High-dose radiation therapy (RT), such as with proton or carbon ions, has been used as an alternative to surgery, but late local failure remains a problem.

Effects of physical exercise on anxiety depression and emotion regulation in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis.

Objective: This systematic review and meta-analysis aimed to comprehensively evaluate the impact of physical exercise interventions on anxiety, depression, and emotional regulation in children diagnosed with attention deficit hyperactivity disorder (ADHD).

Methods: A comprehensive search was conducted across multiple databases, including Embase, Web of Science (WOS), PubMed, The Cochrane Library, Wanfang Data, VIP Information, and China National Knowledge Infrastructure (CNKI), from their inception up to July 2024. The search aimed to identify randomized controlled trials (RCTs) investigating the impact of physical exercise on anxiety, depression, and emotional regulation in children diagnosed with ADHD.

Inter-species dynamics of non-coding RNAs: Impact on host immunomodulation and pathogen survival.

Non-coding RNAs (ncRNAs) are composed of nucleotides that do not encode proteins but instead serve as guides. It interacts with amino acids at precise genomic sites, influencing chromatin structure and gene expression. These ncRNAs contribute to numerous inter-species dynamics, including those within the vector-host-pathogen triad.