Publications by authors named "Ma M"
Article Synopsis
- * By successfully embedding metal cations (K and Na), the interlayer spacing of TiC MXene was expanded from approximately 10.50 Å to 13.10 Å, enhancing its electron and ion transport capabilities.
- * This modification resulted in a significant increase in supercapacitor performance, with the specific capacitance rising by 2.8 times and the rate capability improving from 47.32% to 70.20%.
To develop Monte Carlo simulations to predict the relationship of with liver fat content at 1.5 T and 3.0 T.
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- The new 9th edition of the TNM staging system for lung cancer introduces subdivisions for M1c stage into M1c1 and M1c2 to improve prognosis assessment and treatment strategies for advanced lung adenocarcinoma patients with bone metastases.
- A retrospective study of 126 patients revealed median overall survival of 40.1 months, with patients in the M1c2 group showing significantly poorer outcomes compared to those in the M1c1 group (35.2 months vs. 42.9 months).
- The study identifies performance status and TP53 alterations as key factors influencing survival rates, emphasizing the importance of precise staging in personalizing cancer treatments.
Article Synopsis
- Gut microbiota plays a crucial role in understanding how substances with low bioavailability, like dihydroquercetin (DHQ), can affect colitis and gut health.
- DHQ was found to improve colitis symptoms and restore a healthy gut microbiota by influencing the production of metabolites such as short-chain fatty acids (SCFAs) and their relationship with microRNAs (miRNAs).
- The study suggests that DHQ's anticolitis effects are mediated by SCFAs influencing the miR-10a-5p and PI3K-Akt pathways, revealing a new mechanism of how gut microbiota can impact diseases.
Article Synopsis
- Extubation failure (EF) is a significant issue in ICU patients, particularly those at high risk, leading to negative outcomes; this study focused on whether noninvasive oxygen therapy (NIT) could help.
- A retrospective study compared the impact of NIT versus conventional oxygen therapy (COT) on EF rates in high-risk patients after extubation; results showed that NIT significantly lowered EF (18.0% vs. 34.3%) and reintubation rates (10.5% vs. 18.2%).
- Findings suggest that prophylactic NIT is beneficial for preventing EF, especially in older patients, with high-flow nasal cannula (HFNC) being as effective as nonin
Article Synopsis
- Polymyxins are being tested as a treatment for ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) using different administration methods, especially focusing on intravenous combined with aerosolised delivery.
- A review analyzed 11 studies and found that combining intravenous and aerosolised polymyxins significantly reduced all-cause mortality and improved rates of clinical improvement and microbial eradication compared to using only intravenous polymyxins.
- However, there were no notable differences in clinical cure rates or nephrotoxicity between the two treatment methods, suggesting that aerosolised polymyxins could be a beneficial addition for patients with CR-GNB VAP.
Background: Percutaneous nephrolithotomy (PCNL) is the standard procedure for treating upper urinary tract calculi and complex kidney calculi >2 cm in diameter, though it has a high incidence of postoperative complications. This study aimed to investigate the effect of Orem's management model on patients undergoing PCNL.
Methods: This retrospective study included 465 patients who underwent PCNL from February 2022 to February 2023 from two tertiary hospitals.
Article Synopsis
- Aflatoxin B (AFB) is a harmful contaminant in crops that can negatively impact animal health, and Bacillus CotA laccase has shown promise in breaking down mycotoxins in lab tests, but its effectiveness in live animals needed further evaluation.
- A study involving ducks revealed that Bacillus CotA laccase improved growth rates, gut health, and reduced inflammation caused by AFB, while also positively affecting amino acid metabolism and reducing liver injury.
- Results indicate that Bacillus CotA laccase not only degraded AFB in the digestive tract but also decreased its absorption and presence in the liver and feces, suggesting it could be a viable solution for mitigating AFB toxicosis in ducks.*
Highly-dense small-feature-size nanopatterns and nanoporous membranes are important in advanced microelectronics, nanofiltration, and biomimic device manufacturing. Here, we report the synthesis and self-assembly of a series of high-interaction-parameter (high-χ) silicon-containing hierarchical block copolymers (BCPs) with cross-linkable subordering chalcone motifs, which possess both an intrinsic native etching contrast for nanofabrication and cross-linkability under ultraviolet light for generating free-standing membranes. BCPs with a volume fraction of chalcone block of 55-74% form ordered primary nanostructures with period 15-22 nm including lamellae, double gyroid, hexagonally packed cylinders, and body-centered cubic spheres of the minority Si-containing block.
View Article and Find Full Text PDFHistone modifications of circulating nucleosomes are associated with changes in cell-free DNA fragmentation patterns.
Proc Natl Acad Sci U S A
October 2024
Article Synopsis
- The study focuses on analyzing cell-free DNA (cfDNA) to determine its tissue origin, which is important for research and diagnostics, utilizing a new technique called FRAGHA that looks at fragmentation patterns linked to histone modifications.
- The research demonstrated strong correlations between specific histone modification signals, such as H3K27ac, and various medical conditions, including fetal DNA presence in maternal plasma and liver cancer detection.
- Machine learning algorithms were employed to improve early detection of liver cancer, showcasing how cfDNA fragmentomics can enhance the effectiveness of liquid biopsies in clinical settings.
Article Synopsis
- The FDA regulates medical devices to make sure they are safe and work well before they can be sold.
- A survey was done to understand how the FDA's Medical Devices Advisory Committee makes decisions and what could be improved.
- Out of 92 panel members, most were men and white, and many thought the information from the FDA was fair and that important trials were often designed well.
The azobenzene moiety is an intriguing structure that deforms under UV and visible light, indicating a high potential for biomedical applications. However, its reaction to UV radiation is problematic because of its high energy and low tissue penetration. Unlike previous research on azobenzene structures in photoresponsive materials, this study presents a novel method for imparting photostimulation-responsive properties to liposomes by incorporating the azobenzene moiety and extending the light wavelength with up-conversion nanoparticles.
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- This study looked at how COVID-19 affects kids with rheumatic diseases in China.
- The researchers found that many kids showed symptoms like fever and cough, but most didn’t get very sick.
- Vaccinated kids had a quicker recovery time and were less likely to be hospitalized compared to those who weren’t vaccinated.
Article Synopsis
- Scientists developed a new technique using deep learning to help doctors plan radiation treatment for lung cancer more efficiently.
- They tested this on 74 lung cancer patients and found that their method was really good at predicting how much radiation would be given to different areas.
- The new approach worked almost as well as existing methods but used less data, making it a promising tool for treating lung cancer better.
Mice navigate an odor plume with a complex spatiotemporal structure in the dark to find the source of odorants. This article describes a protocol to monitor behavior and record Ca transients in dorsal CA1 stratum pyramidale neurons in the hippocampus (dCA1) in mice navigating an odor plume in a 50 cm x 50 cm x 25 cm odor arena. An epifluorescence miniscope focused through a gradient-index (GRIN) lens imaged Ca transients in dCA1 neurons expressing the calcium sensor GCaMP6f in Thy1-GCaMP6f mice.
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- Scientists used special data from a detector to look for rare particle decays of a type called the D_{s}^{+} decay, focusing on how it might change into other particles like kaons or pions.
- They found strong evidence for the decay D_{s}^{+}→π^{+}ϕ and also discovered a new decay D_{s}^{+}→ρ^{+}ϕ, both involving particles that decay into pairs of electrons.
- However, they didn't find strong signals for three other types of decays they were looking for, and set limits on how often those changes could happen.
Article Synopsis
- CAR-T cells face challenges in treating solid tumors, notably due to differing antigen expressions and poor persistence, but GUCY2C shows promise as a targeted therapy, especially in colorectal cancer.
- The study involved creating CAR-T cells with an effective single chain variable fragment (scFv) that can also target tumors with low GUCY2C expression, alongside optimizing CAR-T cell designs for long-lasting efficacy.
- Results indicated that the right combination of components in the CAR-T cells improved their tumor-killing ability and longevity, largely attributed to enhanced tonic signaling that allowed the cells to function independently of antigen presence, making them effective against gastrointestinal tumors.
The taproot of Glycyrrhiza uralensis is globally appreciated for its medicinal and commercial value and is one of the most popular medicinal plants. With the decline of wild G. uralensis resources, cultivated G.
View Article and Find Full Text PDFFour previously undescribed compounds talaromyester A () and purpuresters C-E (), together with known purpurester A () and purpuride G (), were isolated from the metabolites produced by the Mariana Trench sediment-derived fungus sp. SY2250. Compounds , two pairs of racemates, were separated on a chiral HPLC column.
View Article and Find Full Text PDFFour lanthanide complexes with 8-hydroxyquinoline-2-aldehyde-2-hydrazinopyridine (H-L), 8-hydroxyquinoline-2-aldehyde-2-hydrazimidazole (H-L): [Sm(L)][Sm(L)(NO)]·CHCl·2CHOH (1), [Gd(L)][Gd(L)(NO)]·CHCl·2CHOH (2), [Sm(L)(NO)]·CHOH (3), and [Eu(L)(NO)]·CHOH (4) were synthesized and characterized. In vitro cytotoxicity evaluation showed that the ligands and four lanthanide complexes exhibited cytotoxicity to the five tested tumor cell lines. Among them, complex 1 showed the best antiproliferative activity against NCI-H460 tumor cells.
View Article and Find Full Text PDFSLC7A11 plays a pivotal role in tumour development by facilitating cystine import to enhance glutathione synthesis and counteract oxidative stress. Disulphidptosis, an emerging form of cell death observed in cells with high expression of SLC7A11 under glucose deprivation, is regulated through reduction-oxidation reactions and disulphide bond formation. This process leads to contraction and collapse of the F-actin cytoskeleton from the plasma membrane, ultimately resulting in cellular demise.
View Article and Find Full Text PDFTo assess a quality improvement project using alternating pressure air mattresses' impact on reducing full-thickness pressure injuries by enhancing setting accuracy and device utilization. We retrospectively evaluated adult acute care unit patients with inclusion criteria (Braden scores ≤12 or existing full-thickness pressure injuries) between May 2020 and August 2023. A wound team attempted to enhance the accuracy, utilization and effectiveness of alternating pressure air mattress implementation.
View Article and Find Full Text PDFA self-reinforcing positive feedback is regarded as a critical process for maintaining alternative stable states (ASS); however, identification of ASS and quantification of positive feedbacks remain elusive in natural ecosystems. Here, we used large-scale field surveys to search for ASS and a positive feedback mechanism under a wide range of habitats on the Tibetan Plateau. Using multiple methods, we proved that three stable states exist that accompany alpine marsh degradation.
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