Bupivacaine Toxicity Increases Transmural Dispersion of Repolarization, Developing of a Brugada-like Pattern and Ventricular Arrhythmias, Which is Reversed by Lipid Emulsion Administration. Study in an Experimental Porcine Model.

Unintentional administration of bupivacaine may be associated with electrocardiogram changes that promote the development cardiac arrhythmias. Ventricular repolarization markers (corrected QT, QT dispersion, Tpeak-Tend and Tpeak-Tend dispersion) are useful to predict cardiac arrhythmias. We aim to investigate the effects of bupivacaine on the transmural dispersion of repolarization and their reversion following intravenous lipid emulsion (ILE) administration.

Differential effects of sevoflurane and propofol on swine cardiac conduction system.

Objective: To compare the effects of sevoflurane and propofol on the porcine cardiac conduction system.

Study Design: A prospective, comparative study of electrophysiological properties of anaesthetics agents in an experimental porcine model.

Animals: A total of 36 hybrid Landrace-Large White pigs.