17-estradiol nanoparticles influence inflammatory response of myocardial infarction possibly through downregulation of miR-302b.

Cardiovascular death is increasing year by year, and effective treatment is a challenging clinical problem at present. The application of nano materials has pointed to a new therapeutic direction for the clinical treatment of cardiovascular diseases, and preparation of nanoparticles (NPs) with PBCA as carrier material has become a trending spot in clinical research. In this study, we observed the influence of 17-estradiol nanoparticles (17-E2-NPs) on the inflammatory response of myocardial infarction (MI) and its regulatory effect on miR-302b.

Fine-Grained Unsupervised Temporal Action Segmentation and Distributed Representation for Skeleton-Based Human Motion Analysis.

Understanding the fine-grained temporal structure of human actions and its semantic interpretation is beneficial to many real-world tasks, such as sports movements, rehabilitation exercises, and daily-life activities analysis. Current action segmentation methods mainly rely on deep neural networks to derive feature embedding of actions from motion data, while works on analyzing human actions in fine-granularity are still lacking due to the lack of clear and generic definitions of subactions and related datasets. On the other hand, the motion representations obtained in current action segmentation methods lack semantic or mathematical interpretability that can be used to evaluate action/subaction similarity in quantitative motion analysis.

Enhanced charge-transfer induced by conduction band electrons in aluminum-doped zinc oxide/molecule/Ag sandwich structures observed by surface-enhanced Raman spectroscopy.

In the semiconductor/molecule/metal system, enhancing the efficiency of the charge-transfer (CT) plays a pivotal role in improving the sensitivity of semiconductor-based surface-enhanced Raman scattering (SERS). In this work, use of SERS for detection of an enhanced CT in a chemically-etched Al-doped ZnO (AZO), 4-mercaptopyridine (MPy) molecule, and Ag nanoparticles (NPs) (AZO/MPy/Ag) sandwich structure is reported. A series of CT routes are proposed in the energy level diagram of AZO/MPy/Ag assemblies under the excitation line at 633 nm.

Application of serum exosomal hypoxia-inducible factor-1 alpha (HIF-1α) as potential circulating biomarker for bacterial peritonitis.

Bacterial peritonitis is a severe disease that diagnosis remains challenging for clinicians. Measuring biomarkers might be a rapid diagnostic method. The objective of this study was to analyze and evaluate the dynamic changes in HIF-1α concentration in serum exosomes during bacterial peritonitis.

Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.

The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied. After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles. The differences of freezing resistance among the three starches were possibly ascribed to the differences in compositions, crystallinity and microstructure among these three starches.

Metal-semiconductor heterostructures for surface-enhanced Raman scattering: synergistic contribution of plasmons and charge transfer.

After 45 years of its first observation, surface-enhanced Raman spectroscopy (SERS) has become an ultrasensitive tool applied in chemical analysis, materials science, and biomedical research. SERS-active nanomaterials, such as noble metals, transition metals, and semiconductors, have undergone extensive development. The hybridization of semiconductors with plasmonic metal nanomaterials is highly effective in boosting light harvesting and conversion, which enables the rapid growth of metal-semiconductor hybrid nanostructures in SERS-based research fields.

Multijointed Pneumatic Soft Hand with Flexible Thenar.

Soft robotic hands provide better safety and adaptability than rigid robotic hands. Furthermore, a multijointed structure that imitates the movement of a human hand represents significant progress in realizing its anthropomorphism. In this study, we present a multijointed pneumatic soft anthropomorphic hand that is capable of expressing letters through sign language and grasping different objects using three grasping modes, namely thumb grasping, precision grasping, and power grasping.

Use of multivariate analysis to evaluate antigenic relationships between US BVDV vaccine strains and non-US genetically divergent isolates.

Bovine viral diarrhea virus (BVDV) comprises two species, BVDV-1 and BVDV-2. But given the genetic diversity among pestiviruses, at least 22 subgenotypes are described for BVDV-1 and 3-4 for BVDV-2. Genetic characterization is generally accomplished through complete or partial sequencing and phylogeny, but it is not a reliable method to define antigenic relationships.

Deciphering the Carrier Transport Properties in Two-Dimensional Perovskites via Surface-Enhanced Raman Scattering.

2D layered organic-inorganic perovskites have attracted substantial attention due to their high stability and promising optoelectronic properties. However, in-depth insights on the anisotropic carrier transport properties of these 2D perovskites are remaining challenging, while they are significant for further designing the high-performance device applications. Here, the carrier transport properties within 2D perovskite single crystals are investigated and a layered-carrier-transport model is developed through the non-invasive and non-destructive surface-enhanced Raman scattering techniques.

Thifluzamide exposure induced neuro-endocrine disrupting effects in zebrafish (Danio rerio).

Thifluzamide is widely used fungicide and frequently detected in aquatic system. In this study, the toxicity of fungicide thifluzamide to non-targeted aquatic organisms was investigated for neuroendocrine disruption potentials. Here, zebrafish embryos were exposed to a series of concentrations of thifluzamide for 6 days.

Genomic Insight Into the Population Structure and Admixture History of Tai-Kadai-Speaking Sui People in Southwest China.

Sui people, which belong to the Tai-Kadai-speaking family, remain poorly characterized due to a lack of genome-wide data. To infer the fine-scale population genetic structure and putative genetic sources of the Sui people, we genotyped 498,655 genome-wide single-nucleotide polymorphisms (SNPs) using SNP arrays in 68 Sui individuals from seven indigenous populations in Guizhou province and Guangxi Zhuang Autonomous Region in Southwest China and co-analyzed with available East Asians a series of population genetic methods including principal component analysis (PCA), ADMIXTURE, pairwise Fst genetic distance, -statistics, , and . Our results revealed that Guangxi and Guizhou Sui people showed a strong genetic affinity with populations from southern China and Southeast Asia, especially Tai-Kadai- and Hmong-Mien-speaking populations as well as ancient Iron Age Taiwan Hanben, Gongguan individuals supporting the hypothesis that Sui people came from southern China originally.

Panoramic smoking burden and genetic susceptibility in relation to all-cause and cause-specific mortality: a prospective study in UK Biobank.

Background And Aims: Various smoking behaviors, including smoking initiation, age of initiation, heaviness of smoking and smoking cessation, have been individually related to the risk of mortality; however, no study has assessed these smoking behaviors jointly in relation to mortality. Our study aimed to measure prospectively the association of panoramic smoking burden (PSB), generated from the four aforementioned smoking behaviors, with all-cause and cause-specific mortality, and measure whether such associations are modified by genetic variations.

Design: Prospective cohort study.

Bismuth Nanoparticles Anchored on Ti C T MXene Nanosheets for High-Performance Sodium-Ion Batteries.

Sodium-ion batteries are promising energy-storage systems, but they are facing huge challenges for developing fast-charging anode materials. Bismuth (Bi)-based anode materials are considered as candidates for fast-charging anodes of sodium-ion batteries due to their excellent rate performance. Herein, we designed a two-dimensional Bi/MXene anode material based on a hydrogen thermal reduction strategy.

Healthy Sleep Patterns and Risk of Incident Arrhythmias.

Background: Emerging evidence has linked sleep behaviors with the risk of cardiac arrhythmias. The various sleep behaviors are typically correlated; however, most of the previous studies only focused on the individual sleep behavior, without considering the overall sleep patterns.

Objectives: The purpose of this study was to prospectively investigate the associations between a healthy sleep pattern with the risks of cardiac arrhythmias.

Obesity and the relation between joint exposure to ambient air pollutants and incident type 2 diabetes: A cohort study in UK Biobank.

Background: Air pollution has been related to incidence of type 2 diabetes (T2D). We assessed the joint association of various air pollutants with the risk of T2D and examined potential modification by obesity status and genetic susceptibility on the relationship.

Methods And Findings: A total of 449,006 participants from UK Biobank free of T2D at baseline were included.

Antidepressant-like Effect of 3-n-Butylphthalide in Rats Exposed to Chronic Unpredictable Mild Stress: Modulation of Brain-Derived Neurotrophic Factor Level and mTOR Activation in Cortex.

3-n-Butylphthalide (NBP), an extract from seeds of Apium graveolens Linn. (Chinese celery), has been demonstrated to have antidepressant effects in suspension chronic-stressed rats by our group. The purpose of this study was to investigate the possible involvement of brain-derived neurotrophic factor (BDNF) and mammalian target of rapamycin (mTOR) in the antidepressant mechanism of NBP.

808 nm Near-Infrared Light-Triggered Payload Release from Green Light-Responsive Donor-Acceptor Stenhouse Adducts Polymer-Coated Upconversion Nanoparticles.

Owing to deep activation in biotissues and enhanced targeting efficiency, developing photoresponsive polymer-upconversion nanoparticles (PP-UCNPs) nanovectors has witnessed rapid growth in the past decade. However, up to date, all developed nanovectors require high-order photon processes to initiate the release of cargos. The photodamage caused by high-power near-infrared laser light may be a critical obstacle to their clinical application.

Targeting Dermal Fibroblast Subtypes in Antifibrotic Therapy: Surface Marker as a Cellular Identity or a Functional Entity?

Fibroblasts are the chief effector cells in fibrotic diseases and have been discovered to be highly heterogeneous. Recently, fibroblast heterogeneity in human skin has been studied extensively and several surface markers for dermal fibroblast subtypes have been identified, holding promise for future antifibrotic therapies. However, it has yet to be confirmed whether surface markers should be looked upon as merely lineage landmarks or as functional entities of fibroblast subtypes, which may further complicate the interpretation of cellular function of these fibroblast subtypes.

Radioactive impacts of the Fukushima Dai-ichi Nuclear Power Plant Accident on blue sharks in the Northwest Pacific.

The Fukushima Dai-ichi Nuclear Power Plant Accident (FDNPPA) derived Cs, Cs and Ag in blue sharks captured in the Northwest Pacific during 2011-2018 were assessed for the first time in the aspects of radioactive contamination, temporal variation, maternal-to-fetus transfer, tissue distribution and radiation dose, to demonstrate the impacts of the FDNPPA on blue sharks. The contribution of the FDNPPA derived radiocesium in blue sharks (>52%) was estimated based on Cs/Cs. The effective and ecological half-lives of the FDNPPA derived Cs (270 d, 410 d), and Cs (430 d, 450 d) were calculated.

Surface Plasmon Resonance from Gallium-Doped Zinc Oxide Nanoparticles and Their Electromagnetic Enhancement Contribution to Surface-Enhanced Raman Scattering.

In recent years, semiconductor-based surface-enhanced Raman scattering (SERS) substrates have received considerable attention and led to a forefront in the SERS field. However, the lack of electromagnetic (EM) enhancement contributions highly precludes the development of semiconductive-substrate-based SERS. In this study, Ga-doped ZnO nanoparticles (NPs) were fabricated and employed as novel SERS substrates based on the EM enhancement contribution of surface plasmon resonance (SPR).

Genomic Insights Into the Admixture History of Mongolic- and Tungusic-Speaking Populations From Southwestern East Asia.

As a major part of the modern Eurasian or Altaic language family, most of the Mongolic and Tungusic languages were mainly spoken in northern China, Mongolia, and southern Siberia, but some were also found in southern China. Previous genetic surveys only focused on the dissection of genetic structure of northern Altaic-speaking populations; however, the ancestral origin and genomic diversification of Mongolic and Tungusic-speaking populations from southwestern East Asia remain poorly understood because of the paucity of high-density sampling and genome-wide data. Here, we generated genome-wide data at nearly 700,000 single-nucleotide polymorphisms (SNPs) in 26 Mongolians and 55 Manchus collected from Guizhou province in southwestern China.

Adherence to a healthy sleep pattern is associated with lower risks of all-cause, cardiovascular and cancer-specific mortality.

Background: Individual unhealthy sleep behaviours have been associated with increased risks of all-cause mortality and deaths due to cardiovascular disease (CVD) or cancer. The evidence regarding the association of sleep patterns with these risks is limited.

Objective: To examine the associations of sleep patterns with all-cause, CVD and cancer mortality in a large prospective cohort.