Publications by authors named "Ma Eugenia Heres-Pulido"
Lead acetate does not inhibit dimethylnitrosamine activation and interacts with phenobarbital which is genotoxic in the ST cross of the Drosophila wing spot test.
Laura Castañeda-Partida Ma Eugenia Heres-Pulido Judith Guzmán-Rincón Luis Barbo Hernández-Portilla Irma Elena Dueñas-García
Food Chem Toxicol
September 2011
Lead acetate (PbAc) is known to inhibit the synthesis of the heme group, needed for hemeproteins like Cytochromes P450 (CYP450s). Dimethylnitrosamine (DMN) requires metabolic activation by CYP450s. The Drosophila wing spot test was performed to establish whether PbAc inhibits DMN activation in the standard (ST) and high bioactivation (HB) crosses, with different levels of CYP450s.
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