Structural Features of Diacyldodecaheterocycles with Pseudo--Symmetry: Promising Stereoinductors for Divergent Synthesis of Chiral Alcohols.

Pseudo--symmetric dodecaheterocyclic structures, which possess two acyl/aroyl groups disposed on either a cis- or trans-relative configuration, were prepared from the naturally occurring (-)-(1)-myrtenal. Addition of Grignard reagents (RMgX) to the diastereoisomeric mixture of these compounds unexpectedly showed that nucleophilic additions to the two prochiral carbonyl centers gave the same stereochemical result in both cis/trans diastereoisomers, making unnecessary the separation of this mixture. Noticeably, both carbonyl groups showed different reactivity because one of them is attached to an acetalic carbon and the other to a thioacetalic carbon.

Antinociceptive activity of the ethanolic extract of DC.

The antinociceptive activity of the ethanolic extract of DC. (EETx) was investigated using the acetic acid-induced writhing and the hot-plate tests in mice. In the acetic acid-induced writhing test, mice treated with EETx (50, 100 and 200 mg/kg, p.

hexanic extract displays synergistic antibacterial activity against .

A phytochemical and antibacterial study of , a species endemic to Mexico, was performed allowing the isolation of six flavones. The minimal inhibitory concentration (MIC) of the hexanic extract, against H37Rv was 25 μg/mL. The hexanic extract caused a significant inhibition of intracellular mycobacterial growth at 12.