Observation of High Spin-to-Charge Conversion by Sputtered Bismuth Selenide Thin Films at Room Temperature.

We investigated spin-to-charge conversion in sputtered BiSe/CoFeB heterostructures with in-plane magnetization at room temperature. High spin-to-charge conversion voltage signals have been observed at room temperature. The transmission electron microscope images show that the sputtered bismuth selenide thin films are nanogranular in structure.

Prediction of LC-MS/MS Properties of Peptides from Sequence by Deep Learning.

Deep learning models for prediction of three key LC-MS/MS properties from peptide sequences were developed. The LC-MS/MS properties or behaviors are indexed retention times (iRT), MS1 or survey scan charge state distributions, and sequence ion intensities of HCD spectra. A common core deep supervised learning architecture, bidirectional long-short term memory (LSTM) recurrent neural networks was used to construct the three prediction models.

Efficacy and safety of endoscopic sleeve gastroplasty for obesity patients: a meta-analysis.

Background: Endoscopic sleeve gastroplasty (ESG) is a minimally invasive, effective, and safe technique for weight loss intervention. Since a relatively small number of cases were present in previous studies, this study aimed to elucidate the efficacy and safety of ESG.

Methods: Relevant publications were identified through searching PubMed, EMBASE, Cochrane, and Web of Science before March 1, 2019.

Immunofluorescent characterization of innervation and nerve-immune cell neighborhood in mouse thymus.

The central nervous system impacts the immune system mainly by regulating the systemic concentration of humoral substances, whereas the peripheral nervous system (PNS) communicates with the immune system specifically according to local "hardwiring" of sympathetic/parasympathetic (efferent) and sensory (afferent) nerves to the primary and secondary lymphoid tissue/organs (e.g., thymus spleen and lymph nodes).

Dihydroartemisinin derivative DC32 inhibits inflammatory response in osteoarthritic synovium through regulating Nrf2/NF-κB pathway.

Synovitis is an aseptic inflammation that leads to joint effusion, pain and swelling. As one of the main drivers of pathogenesis in osteoarthritis (OA), the presence of synovitis contributes to pain, incidence and progression of OA. In our previous study, DC32 [(9α,12α-dihydroartemisinyl) bis(2'-chlorocinnmate)], a dihydroartemisinin derivative, was found to have an antirheumatic ability via immunosuppression, but the effect of DC32 on synovitis has not been fully illuminated.

Endoscopic submucosal tunnel dissection for superficial esophageal neoplastic lesions: a meta-analysis.

Background And Aims: The emerging endoscopic submucosal tunnel dissection (ESTD) is becoming an alternative method for superficial esophageal neoplastic lesions. This study aimed to evaluate the effectiveness and feasibility of ESTD for superficial esophageal neoplastic lesions.

Methods: A comprehensive literature review was conducted to search relevant studies through PubMed, EMBASE, Cochrane Library, and Web of Science before 1 December 2018.

Advanced nitrogen removal without addition of external carbon source in an anaerobic/aerobic/anoxic sequencing batch reactor.

Advanced nitrogen removal without the addition of external carbon source is challenging in the conventional biological nitrogen removal processes. This study presented a novel anaerobic/aerobic/anoxic sequencing batch reactor (A/O/A SBR) based on endogenous nitrate (NO-N) respiration to enhance nitrogen removal. The mean effluent total nitrogen (TN) in the A/O/A SBR could be reduced to as low as 3.

Strengthening Insights in Microbial Ecological Networks from Theory to Applications.

Networks encode the interactions between the components in complex systems and play an essential role in understanding complex systems. Microbial ecological networks provide a system-level insight for comprehensively understanding complex microbial interactions, which play important roles in microbial community assembly. However, microbial ecological networks are in their infancy of both network inference and biological interpretation.

Use of aspirin in the prevention of colorectal cancer through TIGIT-CD155 pathway.

Colorectal cancer (CRC) is one of the most widespread malignant cancers, with a high incidence and mortality all over the world. Aspirin (ASA) otherwise known as acetylsalicylic acid, is a non-steroidal anti-inflammatory drug that has shown promising results in the prevention of chronic diseases, including several cancers. In previous studies, aspirin has been shown to reduce the incidence of CRC.

Regulatory effect of implicit acceptance during outcome evaluation: The temporal dynamics in an event-related potential study.

The acceptance of emotion is important for humans' wellbeing and social functioning. Despite its regulatory advantages, the temporal dynamics of acceptance for regulating decision-related emotion remains unclear. For this purpose, Event-related potentials were recorded for outcome presentation, when participants either in explicit or implicit acceptance condition performed a Gambling Task.

Neuroplastin 65 modulates anxiety- and depression-like behavior likely through adult hippocampal neurogenesis and central 5-HT activity.

Neuroplastin 65 (Np65) is a brain-specific cell adhesion molecule that is highly expressed in the hippocampus, amygdala, and cortex, regions of the brain that are associated with memory and emotions. However, the role of Np65 in regulation of emotional behavior is still unclear. In the present study, we show that Np65 knock-out (Np65 KO) mice display enhanced anxiety-like behavior, a reduction in some aspects of depressive-like behaviors, and increased sociability and memory.

XRN1-associated long non-coding RNAs may contribute to fungal virulence and sexual development in entomopathogenic fungus Cordyceps militaris.

Background: Numerous long non-coding RNAs (lncRNAs) identified and characterized in mammals, plants, and fungi have been found to play critical regulatory roles in biological processes. However, little is known about the role of lncRNAs in insect pathogenic fungi.

Results: By profiling the transcriptomes of sexual and asexual development in the insect-pathogenic fungus Cordyceps militaris, 4140 lncRNAs were identified and found to be dynamically expressed during fungal development.

Protective effects of mesenchymal stem cells overexpressing extracellular regulating kinase 1/2 against stroke in rats.

Objective: Although transplantation of bone marrow-derived mesenchymal stem cells (MSCs) has shown beneficial effects on stroke, lower survival of MSCs limits effects. Extracellular regulating kinase 1/2 signaling (ERK1/2) is crucial for cell survival, differentiation, and proliferation. This study was designed to explore whether MSCs modified by over-expressing ERK1/2 may reinforce beneficial effects on stroke in rats.

Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke.

DNA adducts are believed to play a central role in the induction of cancer in cigarette smokers and are proposed as being potential biomarkers of cancer risk. We have summarized research conducted since 2012 on DNA adduct formation in smokers. A variety of DNA adducts derived from various classes of carcinogens, including aromatic amines, polycyclic aromatic hydrocarbons, tobacco-specific nitrosamines, alkylating agents, aldehydes, volatile carcinogens, as well as oxidative damage have been reported.

Methyl DNA phosphate adduct formation in lung tumor tissue and adjacent normal tissue of lung cancer patients.

The formation of methyl DNA adducts is a critical step in carcinogenesis initiated by the exposure to methylating carcinogens. Methyl DNA phosphate adducts, formed by methylation of the oxygen atoms of the DNA phosphate backbone, have been detected in animals treated with methylating carcinogens. However, detection of these adducts in human tissues has not been reported.

Synthesis of α''-FeN ribbons with a porous structure.

The microstructure of FeCuB ribbons (∼20 μm thick) was modified to fabricate α''-FeN at a temperature as low as 160 °C. The ribbon samples were heat treated first at a temperature reaching 930 °C and then quenched down to room temperature. During the heat treatment, ribbon samples were oxidized, and hydrogen reduction was then conducted to remove the oxygen from the ribbon samples.

Comparative transcriptome analyses provide insights into the adaptation mechanisms to acute salt stresses in juvenile Sinonovacula constricta.

Background: Sinonovacula constricta is an economically important bivalve species in China, Korea and Japan that widely resides in estuarine and coastal areas where salinity fluctuates rapidly. However, little is known about its adaptation mechanisms to acute salt stresses.

Objective: To reveal the underlying molecular mechanisms involved in acute salt stresses in juvenile S.

Percutaneous Pedicle Screw Fixation Alone Versus Debridement and Fusion Surgery for the Treatment of Early Spinal Tuberculosis: A Retrospective Cohort Study.

BACKGROUND Advances in diagnostic imaging techniques make it possible to detect tuberculosis (TB) lesions earlier, when only bone destruction or inflammatory infiltration is demonstrated. These techniques provide doctors with more opportunities to treat TB in the early stages of the disease. Traditional aggressive debridement surgery increases the risk of surgical complications.

milR4 and milR16 Mediated Fruiting Body Development in the Medicinal Fungus .

readily performs sexual reproduction, thus providing a remarkably rich model for understanding the processes involved in sexual development. It could regulate expression of human genes by diet-derived miRNA-like RNAs (milRNAs). However, the study of miRNAs in has been limited.

Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N'-Nitrosonornicotine.

The tobacco-specific carcinogens N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity. NNN and NNK are metabolized to the same reactive diazonium ions, which alkylate DNA forming pyridyloxobutyl (POB) DNA base and phosphate adducts. We have characterized the formation of both POB DNA base and phosphate adducts in NNK-treated rats and the formation of POB DNA base adducts in NNN-treated rats.

Preparation, crystal structure and luminescence properties of a novel single-phase red emitting phosphor CaSr(PO):Sm,Li.

Single-phase CaSr(PO):Sm,Li phosphors were prepared a high-temperature solid-state method under air. The powder X-ray diffraction patterns, scanning electron microscopy images, photoluminescence spectra, and concentration-dependent emission spectra were measured to characterize the as-prepared phosphors and luminescence decay curves. The results showed that the CaSr(PO):Sm,Li phosphors exhibited red luminescence, and the emission spectra of the phosphors consisted of four sharp peaks at around 565, 601 (the strongest one), 647 and 707 nm.

Long-term effect of pH on denitrification: High pH benefits achieving partial-denitrification.

Partial-denitrification (nitrate to nitrite) can supply nitrite for anammox which can reduce organic matter consumption in wastewater treatment plants (WWTPs). In order to achieve stable partial-denitrification, the effect of pH on denitrification were investigated for 420 days in three reactors with influent pH of 5.0, 7.

Genome structure and evolution of Antirrhinum majus L.

Snapdragon (Antirrhinum majus L.), a member of the Plantaginaceae family, is an important model for plant genetics and molecular studies on plant growth and development, transposon biology and self-incompatibility. Here we report a near-complete genome assembly of A.

Flavonoid-Rich Ethanol Extract from the Leaves of Attenuates D-Galactose-Induced Oxidative Stress and Neuroinflammation-Mediated Brain Aging in Mice.

Aging is a major factor that contributes to neurological impairment and neuropathological changes, such as inflammation, oxidative stress, neuronal apoptosis, and synaptic dysfunction. Flavonoids act as protective antioxidant and anti-inflammatory agents against various age-related neurodegenerative diseases. Here, we investigated the protective effect and mechanisms of the flavonoid-rich ethanol extract from the leaves of (FELDK) in the cortex and hippocampus of D-galactose- (gal-) aged mice.