[Noninvasive assessment of age-related changes in female skin microrelief].

Age-related changes in female skin microrelief (33 nonsmoking women at the age from 17 to 80 years) were analyzed by the use of VISIOSCAN VS 98. Measurements were taken on inner side of left forearm at the distance of 2 cm away from the bend of the elbow. It was demonstrated that most responsive indicators of skin chronological aging in magnitudes of correlation coefficient (R) and time increment (I) of age-related changes are the following skin microrelief parameters: V(relievo), R = 0.

[Changes in skin microrelief of smoking and nonsmoking women of different age].

Age-related changes in female skin microrelief (82 nonsmoking and smoking women at the age from 17 to 80 years) were analyzed by the use of VISIOSCAN VS 98. Measurements were taken on inner side of left forearm at the distance of 2 cm away from the bend of elbow. It was demonstrated that such parameters as relievo (V) and roughness (Ser) increased respectively by a factor of 1,23 and 1,50 times in average in group of smoking women of 17 to 28 years old as compared with nonsmoking women of age mate.

[Resection of the stomach with Roux anastomosis].

Results of surgical treatment of patients with gastric ulcer and cancer of the stomach using resection of the stomach with Roux technique were analyzed. Acid-producing and evacuatory functions of the stomach were assessed in different periods after surgery. Dynamic scintigraphy provided evaluation of indices of duodenogastric reflux and state of gastric mucous barrier after various types of surgeries.

[Comparative characteristics of efficacy of operations in ulcerous pyloroduodenal stenosis].

1107 patients with ulcerous pyloroduodenal stenosis (UPDS) were operated since 1968 to 2000. Duodenal ulcers caused stenosis in 1053 (95%) patients, gastric ulcers of types II and III--in 54 (5%). Various stomach resections were performed in 287 (92%) patients organ-saving operations--in 795 (71.

[Secretion, evacuation function of stomach and duodenogastric reflux in patients with ulcerative stenosis of duodenum after various type of operations].

The results of surgical treatment of 118 patients with ulcerative disease of the duodenum, complicated by stenosis, were studied. 58 from them (49.2%) underwent selective proximal vagotomy (SPV) with duodenoplasty and 60 (50.

[Phenomenon of enzymatic imprinting in adult animals].

An inductor of a system of multifunctional monooxygenases, the sovol, being applied to hepatectomized adult rats, produced an enzymatic imprinting, which was expressed in a long-term increase in the aryl hydrocarbon hydroxylase, 7-ethoxycoumarin-deethylase and amidopyrine-N-demethylase activities, as well as in the metabolic activation of benzo (a)-pyrene by the liver S9-fraction in the Salmonella/microsome assay. The phenomena of enzymatic imprinting in adult animals, primarily described, is a reflection of response universality of proliferative cells upon inductors action.

[Imprinting effect of aroclor 1254 in the metabolic activation of benz[a]pyrene by rat liver tissue].

A well-known inductor of a system of multifunctional monooxygenases, the arochlor 1254, being applied to one-day rats produced an imprinting effect which was expressed in a strong and long-term increase in the metabolic activation of benzo(a)pyrene by the liver S9-fraction in the Salmonella/microsome test, as well as in the arylhydrocarbonhydroxylase activity. The imprinting was not revealed when the inductor was applied on the 9th day as well as it was not revealed for 2-acetylaminofluorene in the liver, or benzo(a)pyrene and 2-acetylaminofluorene in the kidneys, independently of the period of application.

[Metabolic activation of chemical carcinogens by rat tissues in the perinatal period].

Metabolic activation of procarcinogenic 2-acetyl-amino-fluorene, benzo(a)pyrene, aflatoxin B1 and N-nitrosodimethylamine by various tissues of embryonal and newborn rats was studied with the Salmonella/microsome assay. Bioactivation by fetal tissues was shown to be significantly lower than with newborn rat tissues. When aroclor was given to pregnant females a decrease in metabolic activation was observed.

[Modifying effect of environmental chemical factors on the metabolic activation of carcinogens].

Current investigations of modifications of metabolic activation of carcinogens by the environmental chemical factors which are able to induce or inhibit the metabolic activation are reviewed. From the standpoint of ecological oncology the most promising are the following trends: 1) modelling under experimental conditions of integral ecosystems including the complex of living organisms, environmental carcinogens, and factors which modify their biotransformation; 2) study of the imprinting effectors of metabolism modifiers; 3) detection in the environment of modifiers of metabolic activation of carcinogens. The comprehensive oncological-ecological studies of chemicals which influence different pathways of carcinogen metabolism are very important for both primary prevention of cancer and the environmental protection.