[The diagnosis of hepatitis C viral infection in blood donors and patients].

The data on the examination of 5139 serum samples, obtained from 3358 blood donors and 1781 somatic patients, for the presence of HCV, HBV and HDV markers. Antibodies (Ab) to HCV were detected, on the average, in 1.56% of the examined blood donors (207 persons).

[Immunoprevention of staphylococcal infections at an industrial enterprise].

The immunogenicity, immunological and epidemiological effectiveness of the subcutaneous, enteral and combined immunizations of the workers at a steel plant with staphylococcal toxoid has been studied. The subcutaneous injection of the adsorbed toxoid in a dose of 0.2 ml by means of the jet injector, model, was accompanied by moderate reactogenicity (the frequency of local reactions was 26.

[Effect of delayed hypersensitivity on the development of an intradermal focus of a staphylococcal infection].

Delayed hypersensitivity (DH) was induced in rabbits by introducing killed St. aureus culture in incomplete Freund's adjuvant. 7 days later the animals were infected intradermally with alpha-toxigenic and leukocidin-active St.

[Efficacy of the per os immunization and reimmunization of man with staphylococcal anatoxin].

By double immunization of 72 persons and single reimmunization of 38 persons per os with tablets containing 100 BU of purified concentrated staphylococcus toxoid (PCST) it was revealed that this immunization was harmless and the immunological response was adequate. The tablets were intended for application through the oral mucosa (oral) or the intestinal tract (enteral); the immunological response depended on the dose of the preparation and the scheme of administration. A high sensitization of healthy persons examined to staphylococcus was found.

[Sensitizing properties of strains of stpahylococci differing in toxigenicity in the immediate hypersensitivity reaction].

The author presents the results of studies on the effect of staphylococcus toxin formation on the origination of allergic reaction. Staph. aureus strains, active producers of the alpha- and gamma-hemolysin, leukocidin, and Staph.

[General regularities of the macrophage reaction in the administration of various antigens and the phagocytosis of microorganisms].

A study of ingestion and elimination of cells of peritoneal exudate (CPE) of mouse labeled antigens of various physico-chemical nature with a simultaneous analysis of their influence on the function of the enzymatic systems of macrophages showed that both the corpuscular (sheep erythrocytes, typhoid vaccine) and the soluble (albumin, endotoxin of S. typhi, tetanus and staphylococcus toxoid) antigens caused a unitypical reaction of the cells of monocytic phagocytic system. Thirty minutes after the administration the principal mass of labeled antigens (albumin, typhoid vaccine, sheep erythrocytes) was phagocytized by macrophages and was revealed chiefly in their phagolysosomal fraction.

[Histopathology and histochemistry of a focus of staphylococcal infection in a sensitized body (material concerning pathogenesis)].

Rabbits were sensitized with a killed St. aureus culture (alpha-toxigenic 0-15 strain); one week later the were infected intradermally with a virulent leukocidin-active St. aureus V8 or with the 0-15 strain.

[Study of the functional activity of the macrophages of animals immunized with staphylococcal alpha-anatoxin].

A study was made by histochemical methods of the activity of the enzymatic systems of macrophages from normal rabbits and those immunized with staphylococcus alpha-toxoid per se and infected with the strains of staphylococcus--producers of alpha-toxin or leukocydin. Immunization of rabbits was accompanied by a reduction in macrophages of the activity of the group of lysosomal enzymes and by an increase in the activity of the redox enzymes. In infection of "immune" macrophages with the living culture of the alpha-toxigenic strains the mentioned changes were more pronounced; no such changes were found after the infection with the leukocydin-active strain.