[ABCG1 transporter gene expression in peripheral blood mononuclear cells of patients with atherosclerosis].

Accumulation of cholesterol in arterial wall macrophages is a main hallmark of atherosclerosis. The ABCG1 transporter mediates cholesterol efflux to high density lipoproteins (HDL) and plays an important role in macrophage foam cell formation. The goal of our study was to investigate the potential role of ABCG1 in atherosclerosis development in humans.

[Individual approach to choosing the exposure time during myocardial perfusion single-photon emission computed tomography].

Objective: To assess whether the quality of the results of myocardial perfusion single-photon emission computed tomography (SPECT) may be improved by applying an individual approach to choosing the exposure time of a study.

Material And Methods: The results of myocardial perfusion SPECT with the radiotracer (RT) Technetril upon 25-sec (short) and 60-sec (long) exposures in 22 patients with valvular heart disease (VHD) and coronary heart disease (CHD) were retrospectively analyzed. The basis for the comparative assessment of the study results was the number of myocardial impulses (NMI).

[ABCA1 mRNA and protein levels in M-CSF-activated macrophages from patients with arterial stenosis].

ABCA1 transporter is one of the key factors defining the level of antiatherogenic HDL in plasma. It is actively involved in the removal of cholesterol from peripheral tissues by reverse cholesterol transport. However, the influence of the level of ABCA1 mRNA and the level of ABCA1 protein 1 in macrophages in atherosclerosis remains unexplored.

[Long-term results of using mononuclear fraction of autologous bone marrow cells in complex surgical treatment of patients with heart valve failure].

The article is devoted to long-term results of pilot clinical investigation of using mononuclear fraction of autologous bone marrow cells as an additional procedure to standard surgical treatment of heart valve failure in order to improve local perfusion and contractive ability of the myocardium. The article presents results of an analysis of findings of the examination of 7 living patients within 6 years or 7 years after operation as also data of pathologicoanatomical investigation of three dead patients. The data obtained show the safety and effectiveness of this method of cell therapy in patients with heart valve failure.

[The APUD-system function of the intestines and the morphological changes in the internal organs of adult rabbits infected with toxigenic Vibrio cholerae].

V. cholerae infection with clearly pronounced diarrhea was reproduced in adult rabbits with the use of the RITARD system. The state of the APUD system of the intestine of the animals and morphological changes in internal organs in experimental cholera were described.

[Blood endorphin levels in myocardial infarction].

Blood gamma-endorphin concentrations were repeatedly measured, using an original radioimmunoassay, in patients with myocardial infarction. In the early days of acute myocardial infarction, high levels of this opioid peptide were observed, then plasma gamma-endorphin concentration gradually decreased by the time of discharge. In patients with grave complications, gamma-endorphin level was significantly lower, as compared to patients with uncomplicated infarction.

[Use of myocardial scintigraphy with Tl-201 and veloergometry in patients with typical stenocardia and atypical pain syndrome].

The results of myocardial scintigraphy with 201Tl used in combination with bicycle ergometry in 19 patients with typical angina and in 41 patients with an atypical pain syndrome are reported. Possible use of a single 201Tl dose at the peak of exercise is considered. The diagnostic value of myocardial scintigraphy with 201Tl was not basically different from that of conventional bicycle ergometry in patients with typical angina, whereas in cases of an atypical pain syndrome myocardial scintigraphy had an essential advantage over bicycle ergometry, which in this case was associated with a noticeably increased number of uncertain or negative results.

[Use of nitroglycerin in the treatment of patients with myocardial infarct].

The effect of the intravenous administration of nitroglycerin on the general course of myocardial infarction as well as on such syndromes as acute left ventricular insufficiency, progressive congestive cardiac failure and the recurring painful syndrome was studied. The assessment of the effect of the drug was carried out in relation to its capacity to limit the extension of myocardial infarction and regulate the blood supply to the organs. The data on the frequency and nature of side-effects following nitroglycerin administration are presented.

[Unresolved problems of the pathogenesis of heart failure in myocardial infarct].

On the basis of the review of their own and literature data, the authors describe a current concept of the development of heart failure in the acute period of myocardial infarction. They also discuss the relationship between the degree of this syndrome and such factors as the extent of necrosis, defects of the regulation of the systemic functions in the first days of the disease, as well as contractility disorders preceding myocardial infarction. The authors suggest original interpretation of the functional impairments in relation to different reactions of acute tension.

[Early diagnostic possibilities in heart failure in myocardial infarct].

In 57 patients on different days of myocardial infarction a comparison of haemodynamic and myocardial contractility parameters was made with their predicted values which were calculated with due consideration of oxygen utilization, arterial pressure and the heart rate. It is established that the majority of patients with myocardial infarction have insufficiency of cardiac output and of contractile activity of the heart beginning with the 1-2d day of illness. At the same time, absolute values of the parameters, stress-caused, can exceed the analogous parameters in patients with ischaemic heart disease outside the period of exacerbation, at rest.

[Use of beta-adrenoblockaders in the therapy of the syndromes accompanying acute myocardial infarct].

The use of beta-adrenoblockers in patients with acute myocardial infarction, accompanied by hypertension and hyperdynamia, leads to normalization of the arterial pressure, of parametres of haemo- and cardiodynamics, to a decrease of the degree of ischaemia of the damaged myocardium and to an increase of the heart work efficacy.

[Central hemodynamic indices studied by use of a tetrapolar variant of integral rheography of the human body].

Integral rheography is conducted by M. I. Tishchenko's method by means of bipolar rheographs which do not ensure accurate reading of the values which form the formula for determining the stroke volume.

[Differential use of glucagon in acute period of myocardial infarct].

The work demonstrates the efficacy of glucagon in acute myocardial infarction and its complications, particularly in bradycardia, hypotension, disorders of cardiac rhythm and conduction, cardiogenic shock, cardiac insufficiency in complete atrioventricular heart block and recurrent forms of ventricular fibrillation. A differential approach and dynamic control over the effect of the drug on the values of hemodynamics, respiration, and metabolism are necessary under the conditions of units of intensive therapy and cardioresuscitation.