N-Acetylcysteine rapidly replenishes central nervous system glutathione measured via magnetic resonance spectroscopy in human neonates with hypoxic-ischemic encephalopathy.

Persistent oxidative stress depletes reduced glutathione (GSH), an intracellular antioxidant and an important determinant of CNS injury after hypoxia ischemia. We used standard, short echo time Stimulated Echo Acquisition Mode (STEAM) to detect GSH by magnetic resonance spectroscopy (MRS) in 24 term neonates with hypoxic-ischemic encephalopathy (HIE), on day of life 5-6, after rewarming from therapeutic hypothermia. MRS demonstrated reliable, consistent GSH of 1·64 ± 0·20 mM in the basal ganglia immediately before intravenous infusion of N-acetylcysteine.

Prognostic assessment for patients with cancer and incidental pulmonary embolism.

Background: An incidental/unsuspected diagnosis of pulmonary embolism (IPE) in cancer patients is a frequent occurrence. This single-institution analysis of uniformly managed patients investigates short and long-term outcomes and proposes a prognostic risk score, aiming to assist clinical decision-making.

Methods: Data from a prospectively recorded cohort of 234 consecutive cancer patients with IPE were analysed.

Trends in Insurance Status Among Patients Diagnosed With Cancer Before and After Implementation of the Affordable Care Act.

Purpose: The Affordable Care Act (ACA) aimed to increase insurance coverage through key provisions such as expansion of Medicaid eligibility and enforcement of an individual mandate. The objective of this study is to examine the impact of the ACA on insurance rates among patients newly diagnosed with colon, lung, or breast cancer.

Methods: Using the SEER database, patients younger than age 65 years diagnosed with colon, lung, or breast cancer between 2008 and 2014 were identified.

Health Care Disparities in Cancer Patients Receiving Radiation: Changes in Insurance Status After Medicaid Expansion Under the Affordable Care Act.

Purpose: To compare insurance status in cancer patients receiving radiation before and after Medicaid expansion under the Patient Protection and Affordable Care Act (ACA), in both expanded and non-expanded states.

Methods And Materials: Newly diagnosed cancer patients aged 18 to 64 years who received radiation from 2011 to 2014 were compiled from the Surveillance, Epidemiology, and End Results database. Patients with a prior cancer diagnosis or unknown insurance status were excluded.

The Perception of Art among Patients and Staff on a Renal Dialysis Unit.

This study investigated the purpose and effectiveness of giving outpatients an opportunity to engage in art activities while receiving dialysis treatment. A mixed method study was conducted. 21 semi-structured interviews were conducted with outpatients attending the dialysis unit and 13 surveys of clinicians were completed.

Diffuse Colour Discrimination as Marker of Afferent Visual System Dysfunction in Amyotrophic Lateral Sclerosis.

Abnormalities of the inner and intermediate retinal structures in patients with amyotrophic lateral sclerosis (ALS) have been described using optical coherence tomography and histopathology. Colour vision is a potential marker of these structural changes. The purpose of this study is to test the hypothesis that colour vision impairment is associated with ALS.

Diagnostic Challenge: Sequential Unilateral Cranial Neuropathies Due to Perineural Spread of Carcinoma.

An 86-year old man developed sequential dysfunction of trigeminal (V1), facial, abducens, trigeminal (v2), oculomotor, and hypoglossal cranial nerves on the right over 20 months. Magnetic resonance imaging (MRI) showed a lesion in the right cavernous sinus. Although there was clinical suspicion that this was related to perineural spread of an extracranial tumour, a primary lesion was not discovered.

Cerebral Venous Thrombosis with Papilloedema Secondary to Skull Base Plasmacytoma.

A 60-year-old woman with history of multiple myeloma was in remission after stem cell transplant 6 years prior. She was undergoing work-up for headaches that were thought to be secondary to a right mastoiditis seen on magnetic resonance imaging (MRI). On routine eye exam, papilloedema was noted.

Validation of Simplified Visual Acuity Testing Protocols in Amyotrophic Lateral Sclerosis.

High- and low-contrast visual acuity (HCVA, LCVA) are potential quantitative markers of neurological dysfunction in amyotrophic lateral sclerosis (ALS). The complex nature and duration of gold standard (GS) protocols precludes widespread use in neurology settings. This study compares simplified to GS visual acuity (VA) protocols.

Top 10 Tips Palliative Care Clinicians Should Know When Caring for Patients with Ovarian Cancer.

The vast majority of women diagnosed with ovarian cancer present with advanced-stage disease with a five-year survival rate less than 50%. Studies have shown that in the past, gynecologic oncologists were not routinely collaborating with palliative care physicians resulting in goals of care planning often not occurring until the last 30 days before death. In recent years, professional societies have been increasingly more vocal about the importance of incorporating palliative care early in a patient's disease course.

Direct top-quark decay width measurement in the lepton+jets channel at with the ATLAS experiment.

This paper presents a direct measurement of the decay width of the top quark using events in the lepton+jets final state. The data sample was collected by the ATLAS detector at the LHC in proton-proton collisions at a centre-of-mass energy of 8 TeV and corresponds to an integrated luminosity of 20.2 fb .

Search for new phenomena in high-mass final states with a photon and a jet from collisions at = 13 TeV with the ATLAS detector.

A search is performed for new phenomena in events having a photon with high transverse momentum and a jet collected in of proton-proton collisions at a centre-of-mass energy of = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider. The invariant mass distribution of the leading photon and jet is examined to look for the resonant production of new particles or the presence of new high-mass states beyond the Standard Model. No significant deviation from the background-only hypothesis is observed and cross-section limits for generic Gaussian-shaped resonances are extracted.

Search for heavy resonances decaying into in the final state in collisions at with the ATLAS detector.

A search for neutral heavy resonances is performed in the decay channel using collision data corresponding to an integrated luminosity of , collected at a centre-of-mass energy of 13 by the ATLAS detector at the Large Hadron Collider. No evidence of such heavy resonances is found. In the search for production via the quark-antiquark annihilation or gluon-gluon fusion process, upper limits on as a function of the resonance mass are obtained in the mass range between 200 and up to 5 for various benchmark models: a Higgs-like scalar in different width scenarios, a two-Higgs-doublet model, a heavy vector triplet model, and a warped extra dimensions model.

Search for doubly charged Higgs boson production in multi-lepton final states with the ATLAS detector using proton-proton collisions at .

A search for doubly charged Higgs bosons with pairs of prompt, isolated, highly energetic leptons with the same electric charge is presented. The search uses a proton-proton collision data sample at a centre-of-mass energy of 13 TeV corresponding to 36.1 of integrated luminosity recorded in 2015 and 2016 by the ATLAS detector at the LHC.

Measurement of the -boson mass in pp collisions at with the ATLAS detector.

A measurement of the mass of the boson is presented based on proton-proton collision data recorded in 2011 at a centre-of-mass energy of 7 TeV with the ATLAS detector at the LHC, and corresponding to of integrated luminosity. The selected data sample consists of candidates in the channel and candidates in the channel. The -boson mass is obtained from template fits to the reconstructed distributions of the charged lepton transverse momentum and of the boson transverse mass in the electron and muon decay channels, yielding where the first uncertainty is statistical, the second corresponds to the experimental systematic uncertainty, and the third to the physics-modelling systematic uncertainty.

Search for dark matter produced in association with bottom or top quarks in TeV collisions with the ATLAS detector.

A search for weakly interacting massive dark-matter particles produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and missing transverse momentum are considered. The analysis uses of proton-proton collision data recorded by the ATLAS experiment at  TeV in 2015 and 2016.

Measurement of polarisation in decays in proton-proton collisions at TeV with the ATLAS detector.

This paper presents a measurement of the polarisation of leptons produced in decays which is performed with a dataset of proton-proton collisions at TeV, corresponding to an integrated luminosity of 20.2 fb recorded with the ATLAS detector at the LHC in 2012. The decays are reconstructed from a hadronically decaying lepton with a single charged particle in the final state, accompanied by a lepton that decays leptonically.

Measurement of longitudinal flow decorrelations in Pb+Pb collisions at and 5.02 TeV with the ATLAS detector.

Measurements of longitudinal flow correlations are presented for charged particles in the pseudorapidity range using 7 and 470 of Pb+Pb collisions at and 5.02 TeV, respectively, recorded by the ATLAS detector at the LHC. It is found that the correlation between the harmonic flow coefficients measured in two separated intervals does not factorise into the product of single-particle coefficients, and this breaking of factorisation, or flow decorrelation, increases linearly with the separation between the intervals.

Measurement of quarkonium production in proton-lead and proton-proton collisions at with the ATLAS detector.

The modification of the production of , , and ( ) in +Pb collisions with respect to their production in collisions has been studied. The +Pb and datasets used in this paper correspond to integrated luminosities of and respectively, collected in 2013 and 2015 by the ATLAS detector at the LHC, both at a centre-of-mass energy per nucleon pair of 5.02 TeV.

Search for the direct production of charginos and neutralinos in final states with tau leptons in collisions with the ATLAS detector.

A search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of collisions corresponding to an integrated luminosity of 36.1 fb , recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV.

Measurement of differential cross-sections of a single top quark produced in association with a boson at with ATLAS.

The differential cross-section for the production of a boson in association with a top quark is measured for several particle-level observables. The measurements are performed using of collision data collected with the ATLAS detector at the LHC in 2015 and 2016. Differential cross-sections are measured in a fiducial phase space defined by the presence of two charged leptons and exactly one jet matched to a -hadron, and are normalised with the fiducial cross-section.

Search for heavy resonances in the and final states using proton-proton collisions at with the ATLAS detector.

A search for heavy resonances decaying into a pair of bosons leading to and final states, where stands for either an electron or a muon, is presented. The search uses proton-proton collision data at a centre-of-mass energy of 13  corresponding to an integrated luminosity of 36.1  collected with the ATLAS detector during 2015 and 2016 at the Large Hadron Collider.

Search for a new heavy gauge-boson resonance decaying into a lepton and missing transverse momentum in 36 fb of collisions at TeV with the ATLAS experiment.

The results of a search for new heavy bosons decaying to an electron or muon and a neutrino using proton-proton collision data at a centre-of-mass energy of  TeV are presented. The dataset was collected in 2015 and 2016 by the ATLAS experiment at the Large Hadron Collider and corresponds to an integrated luminosity of 36.1  .

Prompt and non-prompt elliptic flow in Pb+Pb collisions at Tev with the ATLAS detector.

The elliptic flow of prompt and non-prompt was measured in the dimuon decay channel in Pb+Pb collisions at   with an integrated luminosity of with the ATLAS detector at the LHC. The prompt and non-prompt signals are separated using a two-dimensional simultaneous fit of the invariant mass and pseudo-proper decay time of the dimuon system from the decay. The measurement is performed in the kinematic range of dimuon transverse momentum and rapidity   , , and 0-60% collision centrality.