A multivariable prediction model for invasive pulmonary aspergillosis in immunocompromised patients with acute respiratory failure (IPA-GRRR-OH score).

Purpose: Invasive pulmonary aspergillosis (IPA) is a life-threatening opportunistic infection in immunocompromised patients. The diagnosis is often made late, with mortality reaching 90% when mechanical ventilation is needed. We sought to develop and validate a risk prediction model for the diagnosis of IPA.

Cardiogenic shock in patients with active onco-hematological malignancies: A multicenter retrospective study.

Purpose: Onco-hematological (OH) patients face significant cardiovascular risks due to malignancy and drug toxicity. Data are limited on the characteristics and outcomes of OH patients with cardiogenic shock (CS) in intensive care units (ICUs).

Methods: This multicenter retrospective study included 214 OH patients with CS across 22 ICUs (2010-2021).

Human liver cell-based assays for the prediction of hepatic bile acid efflux transporter inhibition by drugs.

Introduction: Drug-mediated inhibition of bile salt efflux transporters may cause liver injury. In vitro prediction of drug effects toward canalicular and/or sinusoidal efflux of bile salts from human hepatocytes is therefore a major issue, which can be addressed using liver cell-based assays.

Area Covered: This review, based on a thorough literature search in the scientific databases PubMed and Web of Science, provides key information about hepatic transporters implicated in bile salt efflux, the human liver cell models available for investigating functional inhibition of bile salt efflux, the different methodologies used for this purpose, and the modes of expression of the results.

Surface remodeling and inversion of cell-matrix interactions underlie community recognition and dispersal in Vibrio cholerae biofilms.

Biofilms are ubiquitous surface-associated bacterial communities embedded in an extracellular matrix. It is commonly assumed that biofilm cells are glued together by the matrix; however, how the specific biochemistry of matrix components affects the cell-matrix interactions and how these interactions vary during biofilm growth remain unclear. Here, we investigate cell-matrix interactions in Vibrio cholerae, the causative agent of cholera.

An Atypical Mpox Presentation With a Large, Chronic Right Upper Eyelid Ulcerative Mass.

The global outbreak of Mpox has resurged, leading to a significant increase in cases across numerous countries. Mpox infections are associated with potential ophthalmologic complications, such as periorbital skin lesions, blepharoconjunctivitis, keratitis, and vision impairment. Here, we present a retrospective case report of an atypical Mpox in an HIV-positive patient with a persistent 5 × 5 cm ulcerated, round, plaque-like eyelid lesion refractory to multiple treatment regimens.

A newcomer's guide to deep learning for inverse design in nano-photonics.

Nanophotonic devices manipulate light at sub-wavelength scales, enabling tasks such as light concentration, routing, and filtering. Designing these devices to achieve precise light-matter interactions using structural parameters and materials is a challenging task. Traditionally, solving this problem has relied on computationally expensive, iterative methods.

Vibrio cholerae RbmB is an α-1,4-polysaccharide lyase with biofilm-disrupting activity against Vibrio polysaccharide (VPS).

Many pathogenic bacteria form biofilms as a protective measure against environmental and host hazards. The underlying structure of the biofilm matrix consists of secreted macromolecules, often including exopolysaccharides. To escape the biofilm, bacteria may produce a number of matrix-degrading enzymes, including glycosidic enzymes that digest exopolysaccharide scaffolds.

Exploring the Landscape of Perioperative Immediate Hypersensitivity: A Comprehensive 6-Year Monocentric Observational Analysis on Epidemiology and Risk Factors.

Introduction: Perioperative immediate hypersensitivity (POH) is a rare complication estimated at 1/10,000 anaesthesia. The objective of our study was to investigate the risk factors of POH over a 6-year period in a French teaching hospital.

Materials And Methods: A single-centre retrospective descriptive epidemiological study of patients treated in the operating room from January 2016 to December 2021 with and without POH.

Leveraging normative personality data and machine learning to examine the brain structure correlates of obsessive-compulsive personality disorder traits.

Brain structure correlates of obsessive-compulsive personality disorder (OCPD) remain poorly understood as limited OCPD assessment has precluded well-powered studies. Here, we tested whether machine learning (ML; elastic net regression, gradient boosting machines, support vector regression with linear and radial kernels) could estimate OCPD scores from personality data and whether ML-predicted scores are associated with indices of brain structure (cortical thickness and surface area and subcortical volumes). Among older adults (ns = 898-1,606) who completed multiple OCPD assessments, ML elastic net regression with Revised NEO Personality Inventory personality items as features best predicted Five-Factor Obsessive-Compulsive Inventory-Short Form (FFOCI-SF) scores, root-mean-squared error (RMSE)/SD = 0.

Glycogenesis and glyconeogenesis from glutamine, lactate and glycerol support human macrophage functions.

Macrophages fight infection and ensure tissue repair, often operating at nutrient-poor wound sites. We investigated the ability of human macrophages to metabolize glycogen. We observed that the cytokines GM-CSF and M-CSF plus IL-4 induced glycogenesis and the accumulation of glycogen by monocyte-derived macrophages.

Inertial measurement units to evaluate the efficacity of Equino Varus Foot surgery in post stroke hemiparetic patients: a feasibility study.

Introduction: This study evaluates the gait analysis obtained by Inetial Measurement Units (IMU) before and after surgical management of Spastic Equino Varus Foot (SEVF) in hemiplegic post-stroke patients and to compare it with the functional results obtained in a monocentric prospective cohort.

Methods: Patients with post-stroke SEVF, who underwent surgery in a single hospital between November 2019 and December 2021 were included. The follow-up duration was 6 months and included a functional analysis using Goal Attainment Scaling (GAS) and a Gait analysis using an innovative Multidimensional Gait Evaluation using IMU: the semiogram.

Complete resolution of restless legs syndrome following ischemic stroke of the right middle cerebral artery.

Stroke-related restless legs syndrome (sRLS) is an emerging clinical entity, with a clear relationship between stroke and the occurrence of restless legs syndrome (RLS). Dopamine dysregulation has been observed in sRLS of the lenticulostriate region with increased dopamine precursor and decreased dopamine transporter. The aim of this work is to explore an original case of regressive RLS following stroke.

A prospective study of the acquisition of vaginal examination skills using simulation.

Objective: To determine the number of sessions required using procedural simulation to acquire the skill of vaginal examination, which is an essential part of obstetrics, but a difficult learned skill.

Methods: Using a high-fidelity simulator, we conducted a prospective, single-center, single-blind study, at the Angers School of Midwifery. A class of students completed a theory course, and took part in three simulation sessions.

Right anterior insula ASL hypoperfusion as a diagnostic biomarker of prodromal and mild dementia with Lewy bodies: preliminary evidence using a Bayesian approach.

Identifying and validating a biomarker with high specificity in early-stage dementia with Lewy bodies (DLB) using a feasible method is crucial to enhance the current suboptimal diagnostic procedure. Previous research revealed abnormalities, including hypoperfusion in the right anterior insular cortex at group level, in prodromal DLB. Exploring hypoperfusion of the right anterior insula, at an individual-level and assessing its relevance as a potential imaging biomarker in early DLB, has, to our knowledge, not been investigated.

Circulating Nucleosomes as a Novel Biomarker for Sepsis: A Scoping Review.

Circulating nucleosome levels are commonly elevated in physiological and pathological conditions. Their potential as biomarkers for diagnosing and prognosticating sepsis remains uncertain due, in part, to technical limitations in existing detection methods. This scoping review explores the possible role of nucleosome concentrations in the diagnosis, prognosis, and therapeutic management of sepsis.

A Rare Atypical Intrapericardial Prostate Adenocarcinoma Metastasis With 68 Ga-PSMA-11 PET/CT.

We report the case of an 88-year-old man recently diagnosed with prostate cancer. The patient underwent a 68 Ga-prostate-specific membrane antigen-11 PET/CT for staging assessment. This examination revealed intense and expected uptake in the primary prostate cancer, widespread metastatic involvement including typical adenopathy and bone metastasis, and a less common pulmonary lymphangitic carcinomatosis.