[Erectile dysfunction in railway station workers: principles of treatment (prospective randomized study)].

Introduction: Erectile dysfunction is often a consequence of stressful situations, lack of adequate sleep and rest, and sedentary lifestyles. The profession of locomotive engineer implies the presence of these negative factors, which in addition provoke high blood pressure and the development of hypertension.

Materials And Methods: A total of 85 patients of the urological and therapeutic departments of the "Clinical Hospital "Russian Railways Medicine" in the city of Barnaul", working as locomotive drivers or assistant drivers, were examined.

The Improved Biometric Identification of Keystroke Dynamics Based on Deep Learning Approaches.

In an era marked by escalating concerns about digital security, biometric identification methods have gained paramount importance. Despite the increasing adoption of biometric techniques, keystroke dynamics analysis remains a less explored yet promising avenue. This study highlights the untapped potential of keystroke dynamics, emphasizing its non-intrusive nature and distinctiveness.

Lithium-Modified Sorbent: Effects on Hemostatic Responses In Vitro.

The effects of a lithium-modified sorbent based on aluminum oxide and polydimethylsiloxane (AlO@PDMS/Li) and a lithium-free sorbent (AlO@PDMS) on some indicators characterizing blood clotting under hemosorption conditions were compared in vitro. Sorbent AlO@PDMS/Li had significantly lower reactogenic effect on the blood passed through the column than the sorbent without lithium. This was seen from the degree of platelet reduction (66×10 vs 19×10/liter) as well as a less pronounced hypercoagulation shift in chronometric indicators.

Screening of the Promising Direct Thrombin Inhibitors from Haematophagous Organisms. Part I: Recombinant Analogues and Their Antithrombotic Activity In Vitro.

The success in treatment of venous thromboembolism and acute coronary syndromes using direct thrombin inhibitors has stimulated research aimed at finding a new anticoagulant from haematophagous organisms. This study deals with the comparison between hirudin-1 from (desirudin), being the first-known and most well-studied natural anticoagulant, along with recombinant analogs of haemadin from the leech , variegin from the tick , and anophelin from . These polypeptides were chosen due to their high specificity and affinity for thrombin, as well as their distinctive inhibitory mechanisms.

Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity.

Objective: To study the association between high activity of Factor II (prothrombin) in blood plasma with G20210A mutation and the development of great obstetrical syndromes.

Material And Methods: A prospective clinical cohort study was conducted on 290 pregnant women (average age 31.7 ± 4.

[Pathogenesis, diagnosis, prevention and treatment of disseminated intravascular coagulation syndrome in COVID-19 infection].

Aim: Clinical characteristics of disseminated intravascular coagulation (DIC) in COVID-19 infection and assessment of the effectiveness of complex therapy for this syndrome at the stages of prevention and treatment of various complications.

Materials And Methods: The study of publications was carried out through search engines on the Internet using keywords. To diagnose the infection, the COVID-19 program was used on the MeDiCase platform, which is publicly available on www.

Predictive Maintenance of Boiler Feed Water Pumps Using SCADA Data.

IoT enabled predictive maintenance allows companies in the energy sector to identify potential problems in the production devices far before the failure occurs. In this paper, we propose a method for early detection of faults in boiler feed pumps using existing measurements currently captured by control devices. In the experimental part, we work on real measurement data and events from a coal fired power plant.

Malondialdehyde and Uric Acid as Predictors of Adverse Outcome in Patients with Chronic Heart Failure.

In chronic heart failure (HF), some parameters of oxidative stress are correlated with disease severity. The aim of this study was to evaluate the importance of oxidative stress biomarkers in prognostic risk stratification (death and combined endpoint: heart transplantation or death). In 774 patients, aged 48-59 years, with chronic HF with reduced ejection fraction (median: 24.

Clinical and laboratory manifestations of the prothrombin gene mutation in women of reproductive age.

Research Objective: To research the association of prothrombin (factor II) activity given the prothrombin G20210A mutation carriage with its clinical manifestations as thrombotic complications.

Materials And Methods: A prospective clinical cohort study of 290 women of reproductive age was conducted. Two cohort groups were identified: the study group of 140 patients with prothrombin mutation G20210A genotype and the control group of 150 women with G20210G genotype.

Electron density fluctuations in collisional dusty plasma with variable grain charge.

The kinetic theory of electric fluctuations in a collisional weakly ionized dusty plasma is formulated with due regard to the grain charging dynamics. The correlation functions of electron and ion density are obtained by considering their collisions with neutrals described within the Bhatnagar-Gross-Krook model. The electron density correlation spectra in isothermal and nonisothermal plasma are calculated for various values of grain density, grain size, and ion collisionality.

[The role of presepsin in the estimation of disease severity and assesment the treatment efficiency in patients purulent pyelonephritis].

Aim: to determine the importance of a presepsin plasma level for early identification of urosepsis, assessment the severity and efficiency of therapy.

Material And Methods: From 2017 to 2018 . a prospective controlled randomized cohort study with 32 patients (6 men, 26 women) aged from 20 to 60 years was conducted.

Thrombodynamics-A new global hemostasis assay for heparin monitoring in patients under the anticoagulant treatment.

Background: Heparin therapy and prophylaxis may be accompanied by bleeding and thrombotic complications due to individual responses to treatment. Dosage control based on standard laboratory assays poorly reflects the effect of the therapy. The aim of our work was to compare the heparin sensitivity of new thrombodynamics (TD) assay with sensitivity of other standard and global coagulation tests available to date.

A novel explanation for the increased conductivity in annealed Al-doped ZnO: an insight into migration of aluminum and displacement of zinc.

A combined experimental and first-principles study is performed to study the origin of conductivity in ZnO:Al nanoparticles synthesized under controlled conditions via a reflux route using benzylamine as a solvent. The experimental characterization of the samples by Raman, nuclear magnetic resonance (NMR) and conductivity measurements indicates that upon annealing in nitrogen, the Al atoms at interstitial positions migrate to the substitutional positions, creating at the same time Zn interstitials. We provide evidence for the fact that the formed complex of Al and Zn corresponds to the origin of the Knight shifted peak (KS) we observe in Al NMR.

[Cryopresipitate in comprehensive conservative therapy of patients with acute purulent pyelonephritis].

Aim: To investigate the effectiveness of cryoprecipitate in the comprehensive conservative therapy of patients with acute purulent pyelonephritis.

Materials And Methods: We conducted a retrospective analysis of medical records of patients who were diagnosed with acute non-obstructive pyelonephritis from 2007to 2015. During this period, a total of 3912 patients with acute non-obstructive pyelonephritis were treated at the Department of Urology.

Interaction force between two finite-size charged particles in weakly ionized plasma.

The results of numerical studies of the interaction forces between two finite-size charged spherical conductive particles embedded into weakly ionized strongly collisional isothermal plasma-like medium are presented. The studies are performed for the case of particles with fixed electric charge under the assumption that particles do not absorb electrons and ions from the surrounding plasma (colloidal particles) as well as for particles charged by plasma currents (grains). In the first case the Poisson-Boltzmann model was used and in the second the dynamics of grain charging is described in the drift-diffusion approximation.

[Antidotes to novel direct oral anticoagulants].

During the last 10 years, several novel direct oral anticoagulants (NOACs) have entered the clinical arena and were registered in the Russian Federation for use in patients presenting with atrial fibrillation, venous thrombosis, and pulmonary artery thromboembolism. NOACs are classified into two groups: direct thrombin inhibitor (notably dabigatran) and factor Xa inhibitors (including rivaroxaban, apixaban, and edoxaban). Their disadvantage is lack of specific antidotes in case of an emergency situation (injury, infarction, stroke requiring thrombolysis, urgent operation).

First prospective report on immune tolerance in poor risk haemophilia A inhibitor patients with a single factor VIII/von Willebrand factor concentrate in an observational immune tolerance induction study.

Introduction/background: Development of neutralizing inhibitors against factor VIII (FVIII) is a major complication of haemophilia A treatment.

Aim: The ongoing, international, open-label, uncontrolled, observational immune tolerance induction (ObsITI) study evaluates ITI, the standard of care in patients with inhibitors.

Patients/methods: Forty-eight prospective patients in this interim analysis received a single plasma-derived, von Willebrand factor-stabilized, FVIII concentrate (pdFVIII/VWF) for ITI.

[THROMBOGENIC RISK FACTORS IN PATIENTS WITH EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE].

We studied activation of hemostatic reactions together with mechanisms of systemic inflammation and genetic factors responsible for thrombogenic risk in 65 patients suffering exacerbation of chronic obstructive pulmonary disease with 2 or 3 positive criteria proposed by N.Anthonisen at al. (1987).

[Peculiarities of thrombin generation and prognosis of unfavourable outcome in patients with severe pneumonia and pneumogenic sepsis].

The study of thrombin production included 68 patients with severe pneumonia (SP) undergoing monitoring plasma thrombin potential in the thrombin generation test. Thrombin production was found to decrease in the patients who died compared with those alive on days 3-5 and 7-10 after onset of the disease. Endogenous thrombin potential decreased progressively during the first 7-10 days among the patients with the fatal outcome of SP.

[Role of endothelial dysfunction, the interface between hemostatic and system inflammatory responses in the pathogenesis of an infectious inflammation-dependent exacerbation of chronic obstructive pulmonary disease].

Aim: To analyze the systemic manifestations of vascular endothelial damage, the activation of hemostatic and inflammatory responses in patients with an infectious inflammation-dependent exacerbation of chronic obstructive pulmonary disease (COPD).

Subjects And Methods: The paper provides the data of examinations of 111 patients with the clinical signs of an infectious inflammation-dependent exacerbation of COPD who had 2 or 3 positive criteria elaborated by N. Anthonisen et al.

Personalized approach of medication by indirect anticoagulants tailored to the patient-Russian context: what are the prospects?

Indirect anticoagulants such as warfarin are the 'gold standard' for prevention and treatment of thromboembolic complications in patients at risk (in atrial fibrillation of valvular and nonvalvular etiology, the presence of artificial heart valves, orthopedic and trauma interventions, and other pathological conditions). A wide range of doses required to achieve a therapeutic effect indicates the need for a personalized approach to the appointment of warfarin. In addition to the dependence on the patient's clinical characteristics (sex, age, smoking status, diagnosis), there is a clear association between the warfarin dose and the carriage of certain allelic variants of key genes that makes it possible to apply molecular genetic testing for individual dose adjustment.

[The monitoring of application of dabigatran as a remedy of prevention of thromboembolic complications after hip joint arthroplasty].

The analysis was applied to the indicators of hemostasis system under application of new anticoagulant, dabigatran etexilat, after hip joint arthroplasty. It is established that among the coagulation methods analysis the most specific to the effect of dabigatran is the testing of thrombin and echitox time of coagulation. Considering low sensitivity of the echitox to anticoagulation effect of D-dimer the echitox test is optimal for laboratory monitoring of application of dabigatran after orthopedic intervention.

[The preanalytical stage of studying the hemostatic system].

The efficiency of applying precision devices and multiple laboratory methods devised to reveal the causes of bleeding and thromboses significantly depends on whether a wide range of rules of the preanalytical stage of the study is observed. The paper gives detailed information on conditions for taking blood samples, their transport, and preparation for examination of the hemostatic system. The given information is based on the worldwide recommendations and many years' experience gained by the authors at the laboratory of hemostasis.

[Effect of fibrin monomer on spontaneous platelet aggregation].

Fibrin monomer (FM) was shown to cause a considerable increase in artificial shear-induced platelet aggregation. The aggregatory effect of FM was found to be tangibly higher than that in fibrinogen. The mechanism of action of FM on platelet aggregation is hypothesized.