Efficacy of low-dose pravastatin in patients with mild hyperlipidemia associated with type II diabetes mellitus.

A 16 week, randomized, double-blind, parallel, placebo-controlled study was designed to determine the effects of low-dose pravastatin on cholesterol concentrations in patients with mild hypercholesterolemia and non-insulin-dependent diabetes mellitus (NIDDM). Following a 6-to 8-week dietary run-in period, a mean serum total cholesterol (TC) level > 5.2 mmol/L (200 mg/dL), but < 7.

[Calcium and phosphorus metabolism in insulin dependent and non-insulin dependent diabetics, well-controlled and poorly-controlled].

We studied phosphorus and calcium metabolism in 50 adult insulin dependent and non insulin dependent diabetics arranged in 4 groups according to therapy and control of diabetes. We observed: a low level of blood magnesium in all diabetics a lower level of P T H, more pronounced with poorly controlled diabetes. a decrease of 1-25 (OH) 2 D levels without modification of the 25 (OH) D levels in badly controlled diabetics.

[Twin pregnancy with acute hepatic steatosis followed by antehypophyseal insufficiency and diabetes insipidus].

A 22-year old woman in the 37th week of her third pregnancy (twins) developed acute fatty liver complicated with a haemorrhagic syndrome from disseminated intravascular coagulation. Two normal girls were delivered by caesarean section. Persistent surgical bleeding required hysterectomy and a short stay in an intensive care unit.

[Thyroid hormones during a hypocaloric diet in obese patients].

The levels of T3, RT3, T3/RT3, T4, FT4 index or T4/TBG, TSH, at days 1, 4, 8, 15 of a 800-1 000 diet with 60-80 g of carbohydrates, were studied in 45 subjects. Statistical analysis was performed using parametric and non parametric tests for comparison of the mean levels between days 1 and 4, 1 and 8, 1 and 15, 4 and 8, 4 and 15, 8 and 15. We observed no difference between men and women.

[Association of autoimmune dementia, Basedow's disease, and Gougerot-Sjögren syndrome].

The authors observed one case of myoclonic dementia reversible with steroid therapy, associated with Grave's disease and Sjögren's syndrome. A circulating IgG fraction was demonstrated reacting specifically with cerebral micro-vessels and which evolved in parallel with the neuro-psychiatric disturbances. These results support the hypothesis of an autoimmune vasculitis causing the dementia.

[Beta 2 microglobulin in diabetic patients. Apropos of 190 subjects].

Beta-2 microglobulin (beta 2 M) is a low molecular weight protein filtered by the renal glomerulus, then reabsorbed and metabolized at the proximal tubule. Its blood concentration is a good renal index, as it is independent from muscle mass and diet contrary to creatinine. We assayed serum beta 2 M in 190 cases of diabetes mellitus divided into 71 non-insulin-dependent and 119 insulin-dependent forms.

[Study of the course of development in 84 non-insulin-dependent diabetics over a 5-to-10-year period. Their therapeutic outcome].

The clinical, biological and therapeutic course of non-insulin-dependent (type II) diabetes mellitus was studied in 84 patients followed up for five to ten years. Three-quarters of these patients, who had had diabetes mellitus for approximately ten years in most cases, were well controlled although they remained overweight, presumably as a result of poor compliance with nutritional prescriptions. Disturbances in lipids were only incompletely corrected in 60% of patients.

[Insulin reserve of insulin-dependent diabetics. Role of C-peptide in the hormonal balance in diabetes].

Insulin secretion was investigated in 65 insulin-dependent diabetic patients by determining C peptide levels before and after stimulation with either an 800 calories test meal or an injection of glucagon or arginine i.v. Most patients had very low basal C peptide levels and response to all stimulation tests was poor as compared to controls.

[Pituitary-gonadal function in male diabetic patients (author's transl)].

Pituitary-gonadal function was studied in 50 male diabetic patients under 53 years of age. Forty-three had normal sexual activity and 7 were impotent. Plasma testosterone levels and urinary 17 ketosteroids, androsterone and dehydroepiandosterone levels were measured.

[Partial progressive lipoatrophy. A new case-report (author's transl)].

A new case of lipoatrophic diabetes with some peculiar features is reported. The disease was acquired, with onset at approximately thirty years of age, and partial, involving only the face and the upper limbs. The authors were able to observe the successive occurrence of the various symptoms: progressive lipoatrophy, hyperinsulinism, insulin-resistant diabetes, major lipid disturbances, and finally renal failure with a nephrotic syndrome and high blood pressure.

[Association of hyperlipidemia, acute pancreatitis and diabetic keto-acidosis. A case report (author's transl)].

A 32-year-old man was admitted semi-comatose with digestive troubles to the hospital. A diabetic keto-acidosis was discovered. The diabetes was known by the patient for one year and a half, but it was not treated.

[Diabetic proteinuria. Statistical study (author's transl)].

One hundred and six records belonging to diabetics carrying proteinuria were studied by uni-dimensional analysis, then multi-dimensional of thiry-six variables characterizing diabetes, its micro and macroangiopathic complications and the associated biological perturbations with regards to proteinuria. The results permit us to lessen the criterium of risks of the appearance of a diabetic nephropathy and also the linked anomalies.

[Paraneoplasic acrokeratosis of Bazex (author's transl)].

Acrokeratosis of Bazex is a true paraneoplasic syndrome of evocative by its acromegalic and symetric topography of erythemato-keratosic lesions. It always reveals an aerodigestive epithelioma. Its diagnosis is very useful for early treatment of the epithelioma.

[Diabetic proteinuria. Statistical study (author's transl)].

One hundred and six records belonging to diabetics carrying proteinury were studied by uni-dimensional analysis, then multi-dimensional of thirty six variables characterizing diabetes, its complications micro and macroangiopathics and th associated biological perturbations with regards to proteinury. The results permit us to lessen the criterium of risks of the appearance of a diabetic nephropathy and also the linked anomalies.

[Diabetes and chronic pancreatitis. Report of twenty cases (author's transl)].

The association of chronic pancreatitis with diabetes is not very common. Men are the usual victims and ethylism the usual cause. The most common age of onset is between 40 and 50.

[Long term course of insulin secretion in treated noninsulin dependent diabetics (author's transl)].

The long-term effects of sulfonamides were studied by means of hyperinsulinemia tests in 82 diabetics over a period of 12 months (24 months for 30 of them). Whereas for those obese diabetics whose only treatment was dieting--alone or combined with biguanides--hyperinsulinemia attenuates itself as do also variations in glycemia, although some asynchronism remains, in those diabetics treated with sulfonamides--alone or in combination with other treatments--the insulinemia curve is hardly modified.

[Long term course of insulin secretion in treated non-insulin dependent diabetics (author's transl)].

The long-term effects of sulfonamides were studied by means of hyperinsulinemia tests in 82 diabetics over a period of 12 months (24 months for 30 of them). Whereas for those (obese) diabetes whose only treatment was dieting--alone or combined with biguanides--hyperinsulinemia attenuates itself as do also variations in glycemia, although some asynchronism remains, in those diabetics treated with sulfonamides--alone or in combination with other treatments--the insulinemia curve is hardly modified.