Hemorrhagic colitis associated with a rare Escherichia coli serotype.

We investigated two outbreaks of an unusual gastrointestinal illness that affected at least 47 people in Oregon and Michigan in February through March and May through June 1982. The illness was characterized by severe crampy abdominal pain, initially watery diarrhea followed by grossly bloody diarrhea, and little or no fever. It was associated with eating at restaurants belonging to the same fast-food restaurant chain in Oregon (P less than 0.

Cardiac tamponade by loculated pericardial hematoma: limitations of M-mode echocardiography.

Three patients developed cardiac tamponade after heart surgery. Pericardial effusion was not identified by M-mode echocardiography. Two patients underwent two-dimensional echocardiography which showed compression of the right atrium by a localized mass.

Shigellosis in day care centers: use of plasmid analysis to assess control measures.

Spread of shigellosis within day care centers is difficult to control, and illness may spread into the community. We investigated two sequential outbreaks of diarrhea caused by multiply resistant Shigella sonnei in children at day care centers in 2 neighboring counties in Florida. We used plasmid analysis to identify a single epidemic strain causing both outbreaks and to assess the control measures used.

Antagonism of vascular serotonin receptors by m-chlorophenylpiperazine and m-trifluoromethylphenylpiperazine.

m-Chlorophenylpiperazine and m-trifluoromethylphenylpiperazine, two compounds that act as agonists at central serotonin receptors mediating certain neuroendocrine, behavioral and serotonin turnover effects, lacked appreciable agonist activity at serotonin receptors mediating contraction of the rat jugular vein. Instead, these compounds were potent antagonists of serotonin-induced contraction of the jugular vein. Apparently these non-indole compounds affect serotonin receptors in various tissues differently, being agonists in brain but mainly antagonists at some peripheral serotonin receptor sites.

Enkephalin degradation in the guinea-pig ileum: effect of aminopeptidase inhibitors, puromycin and bestatin.

Degradation of enkephalin by aminopeptidases has been established as an important functional mechanism that terminates the pharmacological action of enkephalins in the guinea-pig ileum. Aminopeptidases are a family of enzymes and little is known regarding the specificity of individual enzymes with respect to the degradation of enkephalins. Puromycin is a general inhibitor of aminopeptidases and bestatin is a more selective inhibitor of Leu-aminopeptidases and aminopeptidase B.

Multicentric gliomas of brain and spinal cord.

The clinical and histopathological findings in a child suffering from both cerebral and spinal gliomas of differing histological types are described. There was a family history of von Recklinghausen's neurofibromatosis. The possibility of overlooking the symptoms and signs pointing to a spinal cord lesion in the presence of a known intracranial tumour is stressed.

Effect of labetalol and YM-09538 on neuronal uptake of (3H)norepinephrine in the rat vas deferens.

Labetalol and YM-09538 are combined alpha and beta receptor antagonists with demonstrated antihypertensive activity. Both compounds inhibited the uptake of (3H)norepinephrine into nerves in the rat vas deferens. However, labetalol was approximately 5 fold more potent than YM-09538 as an inhibitor of neuronal uptake.

Multiply antibiotic-resistant Staphylococcus aureus: introduction, transmission, and evolution of nosocomial infection.

A burn patient with a multiply antibiotic-resistant Staphylococcus aureus infection was transferred to Harborview Medical Center from a burn unit in another state. Despite standard wound precautions, transmission to 34 patients occurred during the subsequent 15 months. Twenty-seven of the patients were infected.

High-molecular-weight plasmid correlates with Escherichia coli enteroinvasiveness.

We tested by the Sereny method and examined for plasmids 14 previously Sereny-test-positive and 17 previously untested Escherichia coli strains. The presence of a 140-megadalton plasmid was significantly associated with enteroin-vasiveness as measured by the Sereny test in the 31 E. coli strains examined.

Analysis of the beta 1 and beta 2 adrenoceptor interactions of the partial agonist, clenbuterol (NAB365), in the rat jugular vein and atria.

The potent bronchodilator, clenbuterol, was compared to other beta adrenoceptor agonists with regard to affinity and efficacy for interaction with beta 1, and beta 2 adrenoceptors in the rat jugular vein and atria. Clenbuterol was a potent partial beta adrenoceptor agonist in both tissues based on the following observations: 1. Maximal relaxation of the jugular vein and increases in atrial rate to clenbuterol were less than maximal responses to other beta adrenoceptor agonists.

hard tissue biochemistry: a comparison of fresh-frozen and formalin-fixed tissue samples.

Formalin fixation of hard tissues alters the levels of some, but not all, of the parameters routinely measured by bone researchers. Although mineral parameters (ash weight, particle size (beta 1/2 002) and Ca/PO4 ratio) and lipid parameters (total lipid content and composition, extractability, and Ca-acidic phospholipid phosphate content) are not affected by formalin fixation, the uronate and DNA contents are reduced in formalin-fixed bone while hydroxyproline content is elevated.

Common R-plasmids in Staphylococcus aureus and Staphylococcus epidermidis during a nosocomial Staphylococcus aureus outbreak.

During a 7-month period in 1978 to 1979, 31 patients and personnel at a Kentucky hospital were colonized or infected with a Staphylococcus aureus strain resistant to clindamycin, erythromycin, gentamicin, methicillin, penicillin, and tetracycline. S. epidermidis with similar antibiotic resistance patterns had been isolated in this hospital in the year before the S.

Umbilical vascular catheters: localization by two-dimensional echocardio/aortography.

Umbilical vascular catheters are often necessary in the care of critically ill neonates. Position of the catheter tip is usually determined by roentgenography. Location of the umbilical arterial or venous catheter was determined by 2-dimensional echocardio/aortography in 55 consecutive infants and was compared to localization by thoraco-abdominal roentgenography.