[NGAL as a marker for some extrarenal complications in acute coronary syndrome].

Aim: To study the role of neutrophil gelatinase-associated lipocalin (NGAL) as a marker for extrarenal complications in patients with acute coronary syndrome (ACS).

Materials And Methods: For 110 patients with ACS on days 1-3 of hospitalization, concentrations of NGAL, serum (s-NGAL) and urinary (u-NGAL) NGAL, and N-terminal fragment of pro-B natriuretic peptide (NT-proBNP) were measured, and transthoracic echocardiography was performed. Incidence of cardiovascular complications was determined during the stay in the hospital; hemodynamic parameters (systolic and diastolic blood pressure, heart rate) were measured on admission.

[THE CONTENT OF ELECTROLYTES IN DIFFERENT BIOLOGICAL MEDIUMS UNDER ACUTE CORONARY SYNDROME].

The sampling of study included 172 patients with ischemic heart disease: 146 with acute coronary syndrome, including myocardial infarction (88 patients) and unstable stenocardia (58 patients); 26 patients with stable stenocardia functional class II-III. At the 1-3 day of hospitalization blood was taken of cubital vein. The mixed unstimulated saliva was selected.

[BIOMARKER CONTENT AND ROLE IN HOSPITAL PERIOD OF ACUTE CORONARY SYNDROME].

The study involved 172 patients with coronary heart diseases (CHD) of whom 146 presented with acute coronary syndrome (ACS) including 88 with myocardial infarction (MI), 58 with unstable angina (UA) and 26 with FC II-III stable angina (SA). Interleukin (IL-6, 10), natriuretic peptide (NT-proBNP) levels in blood and 6-hydroxymelatonin level in urine were determined on days 1-3 after hospitalization. These daytime values in ACS were higher than in SA whereas the melatonin level at night was higher in SA than in ACS.

[The acoustic indicator of saliva under stress].

The situation of stress affects various organs and systems that results in development of functional disorders and/or somatic diseases. As a result, different noninvasive, including salivary, techniques of diagnostic of stress conditions are in the process of development. The dynamics of acoustic indicator of saliva is studied during the period of passing the exams.

[The role of necrosis and inflammation markers in prognostication of acute coronary heart disease].

With the incessant growth of cardiovascular mortality, mainly due to myocardial infarction makes prognostication of acute coronary syndrome a principal goal of clinical practice. Biochemical markers (creatine phosphokinase-MB and troponins) are extensively used for diagnostics and prediction of acute coronary heart syndrome (ACS). However, drawbacks of necrosis markers necessitate the search for new ones identifiable at early stages of atherosclerotic plaque instability.

[Immunogenetic predisposition to chronic nonspecific inflammatory bowel disease].

Immunology has grown beyond the classic doctrine of immunity to infectious diseases, and gradually covered the problems of general physiology and pathology, genetics, embryology, transplantation, oncology and many other disciplines. A new direction has appeared--immunogenetics, which should help to answer questions the disposition and/or resistance to disease, as well as influence of environmental factors on implementation of predisposition to the development of pathology. Much attention is paid to investigation of HLA in IBD.

Polymorbidity in inflammatory bowel diseases.

Peculiarities of the electromotor activity of the small intestine and ascending and descending portions of the colon were revealed in patients with inflammatory bowel diseases associated with bronchopulmonary system dysfunction. Functional test revealed an increase in the vital capacity of the lungs due to increased patency of small bronchi.

[Complete elimination of cytomegalovirus without antiviral therapy after systemic mesenchymal stromal cell transplantation in a patient with ulcerative colitis (a clinical case)].

Cytomegalovirus (CMV) is one of the common pathogens of opportunistic infections in patients with inflammatory bowel diseases. When the patients are treated with immunosuppressants that make them more susceptible to CMV, the course of ulcerative colitis (UC) becomes considerably worse. Antiviral therapy sometimes can reduce the risk of complications and the rate of colectomies.

[Pulmonary disorders in patients with chronic inflammatory bowel disease].

The article devoted to respiratory pathology (RP) in patients with UC and CD with clinical-radiological and functional (a function of external respiration--ERF) methods. The study included 220 patients with IBD (164--with UC and 56--with CD), aged 18-76 years (average age 40.6 years).

[External respiratory function in patients with Crohn's disease].

This article presents the results of a study of respiratory function (SRF) in 56 patients with Crohn's disease (CD) who were hospitalized in the Department of intestine pathology in Central research institute of gastroenterology. SRF was determined by spirography and registration of the curve flow--volume forced exhale ("Eton-1, RF). Violations of pulmonary function in CD occurred in 44.

[Neural regulation of the lung-bronchial system in norm and inflammatory bowel disease].

Review focuses on respiratory manifestations of inflammatory bowel disease, identified in the form of fibrosis, emphysema, bronchiectases, and alveolitis. Pathogenesis of the bronchopulmonary complications unduced by a violations of autonomic innervation of the intestine and the bronchial system, changements of the permeability of vascular wall and alveolar epithelium, the development of autoimmune processes.

[Bronchopulmonary lesions in chronic inflammatory bowel diseases].

The paper reviews the literature on bronchopulmonary lesion, one of the least studied systemic manifestations associated with inflammatory bowel diseases (IBD). Knowledge of the entire diversity of extraintestinal manifestations of IBD, including respiratory diseases, allows clinicians to optimize their diagnosis and treatment as the asymptomatic course of the latter may lead to the development of severe respiratory complications. The detection of bronchopulmonary pathology in its early period or during current therapy contributes to the objective assessment of the pattern of the disease, to the correction of treatment and improvement of disease prognosis.

[Gender characteristics of the external respiration violations in patients inflammatory bowel disease].

Article presents results of the study pulmonary function tests in 88 patients (mean age 40.6 yr) with inflammatory bowel disease (IBD): 19 with Crohn's disease and 69 with ulcerative colitis, 44 women and 44 men, 40 smokers and 48 nonsmokers. A pulmonary function abnormality was present in 43 (48.

[Peculiarities of respiratory function in elderly patients with ulcerative colitis].

This article presents a comparative analysis of the frequency and types of violations of respiratory function (RF) in ulcerative colitis (UC) in 29 elderly patients and in 108 patients younger than 60 years. Pulmonary function was studied by spirometry and record the flow curve--forced expiratory volume ("Eton-1"). Prescribe a higher rate of airflow obstruction in older compared with patients younger than 60 years (from 65.

[Allogeneic mesenchymal stromal cells in patients with ulcerative colitis: two years of observation].

Unlabelled: The aim of the study was to determine the efficacy and safety of mesenchymal stromal cells (MSCs) of bone marrow in the treatment of patients with ulcerative colitis (UC).

Materials And Methods: The study included 44 patients with ulcerative colitis (UC), which was implemented MSC transplantation, 40 patients with UC who received standard therapy with mesalazane (salofalka) 4-6 g/day and corticosteroids (prednisone)--1-2 mg/kg, azathioprine--1.5 mg/kg methotrexate 20-50 mg/m2, and 12 patients who underwent induction and maintenance of infliximab therapy.

[Respiratory function in patients with chronic inflammatory bowel diseases].

Article presents results of the study pulmonary function tests (PFT) in 58 inflammatory bowel disease (IBD) patients (mean age 40,3 yr): 12 with Crohn's disease and 46 with ulcerative colitis by spirometry. A pulmonary function abnormality was present in 30 (51,7%) of the 58 symptom free patients and normal radiological results. Pulmonary function abnormalities was present of small airway disease.

[The effect of splenectomy on the immune status of children with active liver cirrhosis].

A complex study of parameters of the systemic cell humoral immunity, secretory immune system, functional state and phagocytic activity of neutrophils as well as activity of the complement and its C3, C4 components in 28 children with active cirrhosis of the liver has shown that the disease was accompanied by a generalized disturbance of the immunity mechanisms. Splenectomy in these children was shown to have favorable influence on the immune status, to reduce activity of the immunopathological process in the liver. At the same time, splenectomy results in continuous suppression of neutrophilic phagocytosis which may be a cause of the development of postsplenectomy septic conditions.

[Blood IgE level in children with chronic viral diseases of the liver].

PRIST was used to examine the time course of changes in the content of total blood IgE in 128 children aged 3 to 15 years suffering from chronic virus hepatitis and liver cirrhosis. A well-defined relationship was discovered between the above parameter and allergic background as well as the process activity in the liver, pointing to the capacity of that class immunoglobulins to reflect the intensity of not only allergic reactions but also of immunopathological processes lying at the basis of chronic active hepatic diseases.