Publications by authors named "MII S"
Article Synopsis
- Brown adipose tissue (BAT) is critical for energy consumption, and its dysfunction can lead to metabolic diseases and obesity, especially as we age.
- The study identifies that perineurial cells, which have reduced antioxidant capacity due to lacking superoxide dismutase 2, impair BAT function by causing sympathetic nerve denervation and reducing fat oxidation.
- Targeting Meflin-expressing stromal cells may be a promising strategy to strengthen BAT function and combat age-related metabolic issues.
Article Synopsis
- - The study analyzed the effectiveness of various hepatic functional tests, specifically modified ALBI score, indocyanine green clearance (ICG-R15), and 99mTc-galactosyl human serum albumin (LHL15) scintigraphy, in predicting posthepatectomy liver failure (PHLF) among patients undergoing liver surgery.
- - Out of 413 patients studied, 19% experienced PHLF, with major hepatectomy, mALBI grade, ICG-R15, and presence of esophagogastric varices identified as significant independent risk factors for developing this complication.
- - The results suggested that LHL15, esophagogastric varices assessment, and the mALBI
Identifying specific markers of adipose stem and progenitor cells (ASPCs) in vivo is crucial for understanding the biology of white adipose tissues (WAT). PDGFRα-positive perivascular stromal cells represent the best candidates for ASPCs. This cell lineage differentiates into myofibroblasts that contribute to the impairment of WAT function.
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- The study investigates the impact of task division among console surgeons during robotic pancreaticoduodenectomy (RPD) on surgical outcomes and education from 2009 to 2023.
- It compares two methods: a single console surgeon versus multiple surgeons, revealing that the multiple approach significantly reduced operation time and postoperative complications.
- The findings suggest that using a multiple approach not only improves surgical results but also enhances learning opportunities for less experienced surgeons.
Article Synopsis
- The study compares two surgical techniques for distal pancreatectomy: robot-assisted approach (RAA) using a laparoscopic vessel-sealing device (LAVSD) and pure-robotic approach (PRA).
- RAA demonstrated significantly shorter operation times and fewer major complications compared to PRA among 62 patients analyzed.
- Despite no statistically significant difference in hospital stay duration, RAA is considered a safe and effective alternative for less experienced surgeons.
Background: The proliferation of cancer-associated fibroblasts (CAFs) hampers drug delivery and anti-tumor immunity, inducing tumor resistance to immune checkpoint blockade (ICB) therapy. However, it has remained a challenge to develop therapeutics that specifically target or modulate CAFs.
Methods: We investigated the involvement of Meflin cancer-restraining CAFs (rCAFs) in ICB efficacy in patients with clear cell renal cell carcinoma (ccRCC) and urothelial carcinoma (UC).
Background: This study aimed to analyze the clinical outcomes after revascularization for chronic limb-threatening ischemia (CLTI) in patients aged ≥ 80 years and < 80 years.
Methods: We retrospectively analyzed multicenter data of 789 patients who underwent infrainguinal revascularization for CLTI between 2015 and 2021. The end points were 2-year overall survival (OS), amputation-free survival (AFS), limb salvage (LS), and postoperative complications.
Article Synopsis
- Pancreatojejunostomy is a complex surgery often performed during robotic pancreaticoduodenectomy (RPD), and the modified Blumgart anastomosis (mBA) method lacks established technical guidelines for robotic use.
- A study at Fujita Health University analyzed data from 78 RPD patients between 2009 and 2023, focusing on the implementation of robotic mBA.
- Results showed a postoperative pancreatic fistula rate of 18%, with no severe complications, and an average anastomotic time of 80 minutes, suggesting that robotic mBA can be a viable standard method for this procedure.
Article Synopsis
- - This study compared the effects of two treatment methods—bypass surgery and endovascular therapy (EVT)—on wound healing in patients with chronic limb-threatening ischemia (CLTI) who have varying conditions of the foot arteries (IM P0 and IM P1).
- - Results showed that bypass surgery led to significantly better wound healing and limb salvage rates in patients with severely diseased pedal arches (IM P1), while both methods had similar outcomes in patients with intact pedal arches (IM P0).
- - The findings suggest that bypass surgery is a more effective option for patients with tissue loss and IM P1 disease, but may not offer additional benefits over EVT for those with healthier foot arteries (IM P0).
Objective: This study aimed to evaluate treatment outcomes after bypass surgery or endovascular therapy (EVT) in average- and high-risk patients with chronic limb-threatening ischemia (CLTI).
Methods: We retrospectively analyzed multicenter data of patients who underwent infra-inguinal revascularization for CLTI between 2015 and 2022. A high-risk patient was defined as one with estimated 30-day mortality rate ≥5% or 2-year survival rate ≤50%, as determined by the Surgical Reconstruction vs Peripheral Intervention in Patients With Critical Limb Ischemia (SPINACH) calculator.
Lung cancer, the leading cause of cancer mortality, exhibits diverse histological subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung cancer, but data from these models are disparate, siloed, and difficult to compare in a centralized fashion. Here we established the Lung Cancer Mouse Model Database (LCMMDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets covering 974 samples from genetically engineered mouse models (GEMMs), 368 samples from carcinogen-induced models, and 12 samples from a spontaneous model.
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- Understanding how different cell types interact is crucial for studying diseases, but current computational methods may overlook important molecular signals during these interactions.
- DeepCOLOR is a new advanced framework that uses deep learning to analyze cell interactions at a single-cell level by combining single-cell data with spatial information.
- It has shown improved accuracy in identifying cell interactions in various biological samples, including mouse brains and human cancer and COVID-19 tissues, allowing for deeper insights into cell communication in different environments.
Pulmonary fibrosis is a fatal condition characterized by fibroblast and myofibroblast proliferation and collagen deposition. TGF-β plays a pivotal role in the development of pulmonary fibrosis. Therefore, modulation of TGF-β signaling is a promising therapeutic strategy for treating pulmonary fibrosis.
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- Robotic pancreaticoduodenectomy (RPD) is complex, requiring 20-50 cases for surgeons to improve, with this study examining 76 RPD cases from a hospital over nearly 14 years to track surgical performance evolution.* -
- Patients were categorized into three groups based on the surgeons' experience: competency, proficiency, and mastery, with significant reductions in operation time and major complications as experience increased across these groups.* -
- Results showed that average operation time significantly decreased from 921.5 minutes to 609.2 minutes, and major complications dropped from 52.2% to 9.1% as surgical techniques were optimized, indicating improved surgeon training and procedural efficiency.*
Objective: This study aimed to evaluate three survival prediction models: the JAPAN Critical Limb Ischaemia Database (JCLIMB), Surgical Reconstruction Versus Peripheral Intervention in Patients With Critical Limb Ischaemia (SPINACH), and Vascular Quality Initiative (VQI) calculators.
Methods: Multicentre data of patients who underwent infrainguinal revascularisation for chronic limb threatening ischaemia between 2018 and 2021 were analysed retrospectively. The prediction models were validated using a calibration plot analysis with the intercept and slope.
Article Synopsis
- Pancreatic tumor enucleation is a surgical method that removes tumors while preserving pancreatic function, and can be done with minimally invasive techniques.
- The da Vinci SP robotic platform, a new single-port robotics technology, was used for this procedure in a male patient in his 70s with a pancreatic neuroendocrine tumor.
- The surgery took 139 minutes with minimal blood loss (4 mL), and the patient recovered well, going home six days post-operation, suggesting that this method is both effective and less invasive.
Background: To investigate the impact of peak aortic jet velocity (Vmax) on the prognosis of patients undergoing open surgery for chronic limb threatening ischemia (CLTI).
Methods: Between April 2015 and March 2022, 352 patients underwent infrainguinal open surgery for CLTI. Patients who met the following exclusion criteria were excluded: subsequent infrainguinal surgeries in the registered period, no record of Vmax, history of aortic valve intervention, and Vmax ≥3.
Objective: To examine limb salvage (LS) and wound healing in dialysis-dependent and -independent patients with chronic limb-threatening ischemia (CLTI) after infrainguinal bypass surgery or endovascular therapy (EVT).
Methods: We retrospectively analyzed the multi-center data of patients who underwent infrainguinal revascularization for CLTI with Wound, Ischemia, and foot Infection (WIfI) stage 2 to 4 between 2015 and 2020. The primary endpoint was LS.
Pancreatic stellate cells (PSCs) are stromal cells in the pancreas that play an important role in pancreatic pathology. In chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), PSCs are known to get activated to form myofibroblasts or cancer-associated fibroblasts (CAFs) that promote stromal fibroinflammatory reactions. However, previous studies on PSCs were mainly based on the findings obtained using ex vivo expanded PSCs, with few studies that addressed the significance of in situ tissue-resident PSCs using animal models.
View Article and Find Full Text PDFShort-Term Results of Varicose Vein Graft Used for Lower-Limb Bypass Surgery.
Ann Vasc Dis
September 2023
: Due to the potential of thrombus blockage and aneurysm rupture, saphenous veins with varicose veins are not advised for use as bypass grafts. However, if no other autologous vein is accessible for use as a conduit in lower-limb bypass; varicose vein transplants may be employed. Few reports have studied the clinical results of lower-limb bypass using varicose vein grafts.
View Article and Find Full Text PDFObjectives: The effectiveness of postoperative medication for the prevention of late graft failure is controversial. We conducted the present study to investigate whether cilostazol improved the mid-term outcomes after infrainguinal autologous vein bypass for chronic limb-threatening ischemia (CLTI).
Methods: From April 1994 to March 2022, we performed 590 de novo infrainguinal bypass procedures using autologous vein grafts (AVGs) in three hospitals.
To estimate the effectiveness of balloon aortic valvuloplasty (BAV) for severe aortic stenosis (SAS) in patients scheduled for open surgery for chronic limb-threatening ischemia. Clinical data of patients from 2012 to 2018 were retrieved and summarized. The early outcomes and survival after BAV and open bypass were retrospectively investigated.
View Article and Find Full Text PDFBackground: The present study aimed to determine the preferred initial revascularization procedure between bypass surgery and endovascular therapy (EVT) in patients with chronic limb-threatening ischemia (CLTI) categorized as indeterminate according to the Global Vascular Guidelines (GVG).
Methods: We retrospectively analyzed the multicenter data of patients who underwent infrainguinal revascularization for CLTI categorized as indeterminate according to the GVG between 2015 and 2020. The end point was the composite of relief from rest pain, wound healing, major amputation, reintervention, or death.
Surgical techniques and outcomes of minimally invasive anatomic liver resection (AR) using the extrahepatic Glissonian approach for hepatocellular carcinoma (HCC) are undefined. In 327 HCC cases undergoing 185 open (OAR) and 142 minimally invasive (MIAR; 102 laparoscopic and 40 robotic) ARs, perioperative and long-term outcomes were compared between the approaches, using propensity score matching. After matching (91:91), compared to OAR, MIAR was significantly associated with longer operative time (643 vs.
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- Robotic surgery offers benefits like high optical magnification and precise movement of forceps but has limitations such as a narrow surgical field and lack of tactile feedback.
- In a case involving an 80-year-old man undergoing robotic distal pancreatectomy, injury to the splenic artery resulted in severe and uncontrollable bleeding.
- Surgeons must remain vigilant about the interaction of robotic instruments with surrounding structures, emphasizing the need for regular assessments of the surgical field to prevent errors.