Publications by authors named "MICHEL A"

Constructed wetlands (CWs), originally designed to mitigate chemical water pollution, often host noticeable aquatic fauna. However, little is known about the impact of the contaminants circulating within CWs on this local fauna, questioning the role of CWs as ecological refuges or traps. We aimed to assess the potential of an agricultural CWs in northern France to act as an ecological trap for aquatic fauna and the potential consequences on wetland functioning.

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Background: The 2019 ASCCP Risk-Based Management Consensus Guidelines prefer expedited treatment, defined as proceeding to excisional treatment without first performing colposcopic biopsy, for patients with screening results indicating a high risk of cervical precancer. In this mixed methods study, we explored clinician attitudes toward expedited treatment.

Methods: In 2021, a national sample of 671 clinicians who performed colposcopy completed surveys; a subset (n = 41) of clinicians who performed colposcopy and/or directed patient treatment completed qualitative interviews.

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Introduction: Vaccine mandates have been used to minimize the duty days lost and deaths attributable to infectious disease among active duty Service members (ADSMs). In response to the global COVID-19 pandemic, in August 2021, the U.S.

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Anxiety is highly prevalent among college communities, with significant numbers of students, faculty, and staff experiencing severe anxiety symptoms. Digital mental health interventions (DMHIs), including Cognitive Bias Modification for Interpretation (CBM-I), offer promising solutions to enhance access to mental health care, yet there is a critical need to evaluate user experience and acceptability of DMHIs. CBM-I training targets cognitive biases in threat perception, aiming to increase cognitive flexibility by reducing rigid negative thought patterns and encouraging more benign interpretations of ambiguous situations.

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Background: Despite the association of pathogenic variants (PVs) in cancer predisposition genes with significantly increased risk of breast cancer (BC), uptake of genetic testing (GT) remains low, especially among ethnic minorities. Our prior study identified that a patient decision aid, RealRisks, improved patient-reported outcomes (including worry and perceived risk) relative to standard educational materials. This study examined patients' GT experience and its influence on subsequent actions.

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Bovine brucellosis and bovine tuberculosis are zoonotic diseases with economic and public health importance across the world, especially in developing countries where the diseases are endemic. The diseases are classified as neglected diseases in developing nations with poor resources despite good control measures in some developed countries. The purpose of this study is to assess the knowledge, attitudes and perceptions (KAP) of stakeholders towards control measures for bovine brucellosis (BR) and bovine tuberculosis (bTB) at a livestock-wildlife interface.

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Background/objectives: Cancer patients often experience psychological and physical symptoms that can significantly impact their quality of life and treatment outcomes. Virtual reality (VR) has emerged as a promising complementary approach to standard cancer care. Due to the rapidly evolving nature of VR research in oncology, it seems essential to provide an overview of the current state of knowledge in this field.

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Ribosome profiling (Ribo-Seq) has revolutionised our understanding of translation, but the increasing complexity and volume of Ribo-Seq data present challenges for its reuse. Here, we formally introduce RiboSeq.Org, an integrated suite of resources designed to facilitate Ribo-Seq data analysis and visualisation within a web browser.

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Existing sensors for measuring dissolved methane in situ suffer from excessively slow response times or large size and complexity. The technology reported here realizes improvements by utilizing a hollow core optical fiber (HFC) as the detection cell in an underwater infrared laser spectrometer. The sensor operates by using a polymer membrane inlet to continuously extract dissolved gas from water.

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Article Synopsis
  • Previous studies indicated a higher risk of acute myocarditis after COVID-19 infection, but it was unclear if this risk was greater than after other viral infections like influenza.
  • A retrospective cohort study analyzed health claims in the U.S. to compare myocarditis rates post-COVID-19 and influenza infections, finding increased rates of myocarditis in COVID-19 patients.
  • The study showed that 0.06% of COVID-19 patients were diagnosed with myocarditis compared to 0.02% in influenza patients, suggesting a notable risk increase associated with COVID-19, especially in younger males with cardiac conditions.
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The autonomy of elderly people living with diabetes must be encouraged, even when they are institutionalized. A comprehensive assessment is the first step towards maintaining this therapeutic autonomy. Tools and procedures are available to promote personalized diabetes care plans.

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Unlabelled: Microplastics (MPs) have been found in a diverse range of organisms across trophic levels. While a majority of the information on organismal exposure to plastics in the environment comes from gastrointestinal (GI) data, the prevalence of MP particles in other tissues is not well understood. Additionally, many studies have not been able to detect the smallest, most prevalent, MPs (1 µm - 5 mm) that are the most likely to distribute to tissues in the body.

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Article Synopsis
  • Evidence shows that human-induced waste significantly impacts deep-ocean ecosystems, with debris being found even in remote areas during initial explorations.
  • A study in the tropical Atlantic and Caribbean Sea recorded various types of marine debris, including plastic, metal, and glass, at depths ranging from 250 to over 6000 meters, observed using submersibles.
  • The discovery of 139 debris items—such as a ladder, clothing, and single-use packaging—highlights the severity of pollution in these deep waters and underscores the importance of understanding its effects on ocean sustainability.
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Objective: To investigate exposures associated with outpatient rehabilitation encounters among Military Health System (MHS) beneficiaries with major limb loss.

Design: Retrospective, cohort study.

Setting: American military treatment facilities and civilian health care facilities that accept TRICARE benefits.

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Background: Women with high-risk breast lesions, such as atypical hyperplasia (AH) or lobular carcinoma in situ (LCIS), have a 4- to tenfold increased risk of breast cancer compared to women with non-proliferative breast disease. Despite high-quality data supporting chemoprevention, uptake remains low. Interventions are needed to break down barriers.

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Objective: To analyse the potential impact of patients' sex, race, and region/country on the risk of hypersensitivity reactions after intra-venous or intra-arterial administration of iopromide.

Methods: Two analyses were performed. (1) The "Phase-IV-Analysis" evaluated an integrated pooled database of 4 non-interventional studies.

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Adoptive cell therapy (ACT) using in vitro expanded tumor-infiltrating lymphocytes (TILs) has inconsistent clinical responses. To better understand determinants of therapeutic success, we tracked TIL clonotypes from baseline tumors to ACT products and post-ACT blood and tumor samples in melanoma patients using single-cell RNA and T cell receptor (TCR) sequencing. Patients with clinical responses had baseline tumors enriched in tumor-reactive TILs, and these were more effectively mobilized upon in vitro expansion, yielding products enriched in tumor-specific CD8 cells that preferentially infiltrated tumors post-ACT.

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Most deep-ocean life relies on organic carbon from the surface ocean. While settling primary production rapidly attenuates in the water column, pulses of organic material can be quickly transported to depth in the form of food falls. One example of fresh material that can reach great depths across the tropical Atlantic Ocean and Caribbean Sea is the pelagic macroalgae .

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Background: Fear of cancer recurrence (FCR) affects virtually all patients who have been treated for cancer, to varying degrees. Breast cancer survivors who carry a BRCA1 or BRCA2 gene mutation are at high risk of cancer recurrence. No study has yet assessed FCR specifically in this population.

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We sequenced and genotyped severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza, adenovirus, and respiratory syncytial virus, among other pathogens, from residual anterior nasal swabs self-collected for rapid SARS-CoV-2 antigen testing at the US Naval Academy. This is a key proof-of-concept for an acute respiratory infection surveillance approach, which could leverage prevalent SARS-CoV-2 antigen self-testing.

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Background: Childhood mental health issues concern a large amount of children worldwide and represent a major public health challenge. The lack of knowledge among parents and caregivers in this area hinders effective management. Empowering families enhances their ability to address their children's difficulties, boosts health literacy, and promotes positive changes.

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Article Synopsis
  • - In vitro assessments for predicting pharmacokinetic (PK) behavior in biotherapeutics help identify potential issues early in drug discovery, reducing excessive animal testing and optimizing resources.
  • - The study highlights the value of integrating in vitro measures, particularly those assessing nonspecific interactions and FcRn interactions, as they correlate well with drug clearance in a specific mouse model.
  • - A computational method is proposed to enhance the correlation to PK by combining various in vitro measurements with multivariate regression, allowing for better prioritization of drug candidates with ideal PK profiles.
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