Compendial Methods: Suitability Verification, Challenges and Recommendations for Proteins.

Compendial testing methods are not required to be fully validated, but their suitability for testing should be verified under actual conditions of use. This requirement is established in 21 CFR 211.194(a)(2) of the current Good Manufacturing Practice regulations in the United States.

Characterization of particles in protein solutions: reaching the limits of current technologies.

Recent publications have emphasized the lack of characterization methods available for protein particles in a size range comprised between 0.1 and 10 μm and the potential risk of immunogenicity associated with such particles. In the present paper, we have investigated the performance of light obscuration, flow microscopy, and Coulter counter instruments for particle counting and sizing in protein formulations.

The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger.

This report describes the construction of a questionnaire to measure three dimensions of human eating behavior. The first step was a collation of items from two existing questionnaires that measure the related concepts of 'restrained eating' and 'latent obesity', to which were added items newly written to elucidate these concepts. This version was administered to several populations selected to include persons who exhibited the spectrum from extreme dietary restraint to extreme lack of restraint.

Dimensions of Cognitive Closure.

This study investigated the generality of the perceptual factors of speed and flexibility of closure in the cognitive domain. Several experimental measures of both flexibility and speed of closure employing perceptual or figural content, verbal or symbolic content, and semantic content were administered to 541 Naval Aviation Cadets, along with marker measures for several established factors. In addition to several of these marker dimensions, factors were obtained for both flexibility and speed of figural closure, of verbal or symbolic closure, and of semantic closure, along with a dimension tentatively interpreted as flexibility of grammatical closure.

Personality Consistencies In Judgment : Dimensions Of Role Constructs.

Eighty-four males and 79 females judged similarities and differences among 16 dominant figures important in interpersonal functioning, such as mother, self, best friend, or liked -her. The individual differences model of multidimensional sealing, in separate analyses far the two sexes, uncovered six dimensions of viewpoint for females and seven for males. Individual scores on these viewpoint dimensions were found to be significantly correlated with certain cognitive and personality measures.