Asxl2 Mice Exhibit De Novo Cardiomyocyte Production during Adulthood.

Heart attacks affect more than seven million people worldwide each year. A heart attack, or myocardial infarction, may result in the death of a billion cardiomyocytes within hours. The adult mammalian heart does not have an effective mechanism to replace lost cardiomyocytes.

Cerebrovascular, cardiovascular and renal hypertensive disease after hypertensive disorders of pregnancy.

Background: Strong associations have been established in nationwide registry studies between hypertensive disorders of pregnancy (HDP) and later vascular morbidities and mortality. The aim of this case-control study is to examine the interdependent relationships of different predictive factors for vascular disease and HDP, because they are not clearly elucidated due to lack of detail in registries.

Methods And Results: We assembled three different case groups of women who had cerebrovascular, cardiovascular, or hypertensive kidney disease before the age of 55.

Everyday regional anesthesia in children.

Regional anesthesia in children is an evolving technique with many advantages in perioperative management. Although most regional anesthesia techniques are sufficiently described in the literature, the implementation of these techniques into daily clinical practice is still lacking. The main problems associated with pediatric regional anesthesia (PRA) include the appropriate selection of blockade, the management around the block, and how to teach these techniques in an optimal manner.

Fibreoptic nasal intubation in children with anticipated and unanticipated difficult intubation.

The establishment of a tracheal airway with direct laryngoscopy can be either a very difficult or an impossible task in children with congenital or acquired facial malformations. Out of 46 patients categorized as difficult tracheal intubation, fibreoptic laryngoscopy was used successfully in 44 children anaesthetized by mask with sevoflurane and oxygen or by an intravenous infusion of propofol and mask oxygenation. There were two failures (4.

[Role of glomus shunts of the anorectal cavernous bodies in the mechanism of hemorrhoid development].

Histological examination of the hemorrhoids in 67 preparations of the rectum of adult persons showed the significance, in their development, of glomus and glomus blocking arteriovenous anorectal cavernous bodies, the two-three-fold increase of their volume was established. The dilatation of the glomus body lumen (from 20-30 to 270-480 microns) in the cavernous body wall is due to the epithelioid cell atrophy and sclerosis. When persistent dilatation and shortening of the distance between glomus mouths occurs, arterial blood passes from the peripheral branches of the superior rectal artery directly to the vena lumen, resulting, first, in the development of a simple compensatory and then varicose angioma-like flebectasia.

Ultrastructural characteristics of renal corpuscle evolution in vertebrates.

Peculiarities of renal corpuscle's structural organization of a number of animals representing various classes of vertebrates have been studied on submicroscopic level at the stages of excretory organs formation: pronephros, mesonephros and metanephros. The fact has been established that side by side with the common structure there have been specific peculiarities due to the level of evolutional development and character of habitat.

[Morpho-functional changes in the muscles of the limbs and their microcirculatory bed in acute ischemia].

On 26 mature dogs in a chronic experiment the character of compensatory-adaptive changes in muscles and their blood capillaries have been studied in dynamics of an acute ischemia of the extremity and at some stages of recirculation. After strangulation for two hours, thanks to joining in the compensatory-adaptive mechanisms, certain morphofunctional changes in the extremity tissues are revealed. As the duration of hypoxia increases (6-9 h), the destructive changes in the tissues become more severe.

[Innervation opf the juxtaglomerular complex (JGC) of the kidney in vertebrates].

On the base of electron microscopic investigations of kidneys, performed on some representatives of vertebrata (fishes, amphibia, reptiles, birds, mammalia) the data on their JGC innervation are presented. In the course of evolution the structure of nervous-muscular, nervous-endocrine and nervous-epithelial contacts becomes more complex. The role of the nervous factor in regulation of the systemic blood flow and water-salt metabolism acquires a greater significance in the process of development.

[Effect of fasting and maintenance solutions on perioperative blood glucose in children].

The effects of fasting on preoperative glycemic levels and the influence of different intravenous solutions on postoperative sugar levels are discussed. Sugar levels were determined in 90 children, randomly placed in three groups, (according to the solution they were administered-A: Ringer-lactate, B: glucose at 5%, C: mixed-2 x 1) at the time they entered the hospital, after fasting previous to the anesthetic induction, and in the immediate postoperative period. In 14.

[Compensatory-adaptative processes of the kidney after undergoing hydronephrotic transformation].

In experiments on 30 white mongrel adult rats of both sexes pathologic and reparative alterations in the kidney by the 30th day after recanalization of the ureter occluded for 1, 3, 7, 10, 15, 30 days have been studied using microdissection, light optic and electron microscopic methods. The fact has been established that in early times of HT (1 to 3 days) with the following reduction of urinary passage through the ureter (30 days), the canalicular-vascular formations of the kidney acquire normal morphological structure. In cases of more prolonged occlusion of the ureter (15 to 30 days) in the kidney noticeable destructive alterations prevail with replacement of parenchymatous elements by connective tissue.

[Morphologic changes in limb muscles under conditions of acute experimental ischemia and recirculation].

Acute ischemia was induced in the limbs of 48 dogs by wounding femoral vessels followed by hemostasis through ligation of the vessels or application of a tourniquet for 2, 4, 6 and 9 hours with subsequent blood flow restoration in the great vessels. Morphological changes were examined in the muscular tissues using light optic and ultrastructural techniques. The results showed that the vascular ligation caused reactive reversible nonspecific changes in the limb tissues, the magnitude of the changes was found to be associated with hypoxia duration.

[Anatomy in public health practice].

In the article attention is paid to the necessity to draw nearer morphological investigations to the problems of practical medicine. These investigations are especially important during the period of the health protection reorganization. Short annotations of some scientific-practical works are presented.

[The circulatory bed of the human uterine tube].

By means of combined morphological methods blood vessels have been studied in 54 uterine tubes of child-birth women. The main pathways for carrying and distribution of blood to corresponding parts of the tube are sector arteries. They are situated in the subserous tela along the anterior and posterior semicircles of the organ.

[Effect of helium-neon laser radiation on restoration of the structure of the microcirculatory bed and neurocytes of the small intestine following experimental ischemia].

Influence of helium-neon laser lg-75 rays on the microcirculatory bed and neurocytes of the small intestine after its experimental ischemia has been studied. When a normal small intestine is radiated, dilatation of the luminal diameter is observed in all links of the microcirculatory bed (MCB) and also hypertrophy of neurocytes, when phenomena of distrophic processes are absent. In 30 days after 3-hours' ischemia of the intestinal loop and its successive radiation, spasm of arterial and dilatation of the venous link of MCB is registered; they normalize by the 45th day.

[Reorganization of the vascular and nerve elements of the small intestine following resection of a strangulated loop].

Adaptational and compensatory changes in neurovascular structures of the small gut's myenteric plexus following resection of a strangulated loop of the gut were studied in 21 cats. It was found, in particular, that whereas hyperplastic processes predominated in the wall of the remaining small gut at 1 month postresection, reparative processes had largely ceased and the neural structures under study had undergone partial atrophy at 3-6 months.

[Morphometric characteristics of neuromuscular spindles in hypertrophied skeletal muscle].

Skeletal muscle hypertrophy in young male rats was found to be accompanied by adaptive changes in neuromuscular spindles. The changes consisted in connective capsule thickening, increased diameter of NMS and intrafusal muscle fibers, expanded afferent and efferent nerve terminals, increased microcirculatory bed capacity. The quantitative and qualitative shifts observed in NMS structure are morphologically equivalent to the rise in their functional potential, which forms the basis for the functional changes in conditions of increasing skeletal muscle hypertrophy.