Fatal outcome of herpes simplex virus type 1-induced necrotic hepatitis in a neonate.

In neonates, herpes simplex virus (HSV) infections can lead to severe diseases associated with high mortality. We report a 6-day-old girl who developed clinical signs of fulminant hepatic failure accompanied by infectious-toxic shock and disseminated coagulopathy secondary to HSV type 1 (HSV-1) infection. The diagnosis was performed postmortem by demonstration of HSV-1 DNA in liver tissue as well as by retrospective detection of HSV-specific antibodies.

[Odontogenic fibromyxoma of the mandible].

Odontogenic fibromyxomas are extremely rare, benign odontogenic tumours, found preferentially in the second and third decades of life. They have a preference for the mandible. The present case report describes a 25-year-old patient with an odontogenic fibromyxoma in the lower jaw.

[Ameloblastic fibroma of the maxilla].

Ameloblastic fibromas are rare benign odontogenic tumours, which appear preferentially in adolescents and young adults. They are most often found in the mandible. The present case report describes a 40-year-old patient with an ameloblastic fibroma in the upper jaw, an extremely rare site.

Phagocytosis of surfactant by alveolar macrophages in vitro.

Because of their localization and function as phagocytes, alveolar macrophages could take part in the catabolism of surfactant, including surfactants used for treatment. Conditions of the ingestion of the surfactant preparation AWD 56-02 by alveolar macrophages in vitro are described in this paper. The surfactant was labeled with rhodaminyl phosphatidylethanolamine and incubated with alveolar macrophages lavaged from rat lungs.

[A case report of welder's lung].

The case of a 57-year-old man is reported, who worked as a plasma welder about 15 years. Chronic recurrent bronchitis was diagnosed 12 years after beginning of this work. The patient changed the place of his employment but the course of disease was uncommonly progressive.

[Unusual complications at birth in a stillborn with spinal muscular atrophy].

A report is given on a premature stillborn with severe congenital spinal muscular atrophy, arthrogryposis multiplex congenita and hydrops fetalis. During delivery the head was spontaneously pulled off. The neuromuscular disease was the cause of this unusual complication.

[Desmoplastic fibroma as a rare bone tumor].

A desmoplastic fibroma of the left humerus with a pathological fracture in a 9-year-old girl is presented. The postoperative course was uncomplicated: no recidive occurred. The histological picture of this rare bone tumor (76 similar cases were reported in the literature) is identical both with aggressive fibromatosis and with the desmoid tumor.

Influence of imipramine and chloroquine on lung phospholipid content and lung structure in newborn rats.

In continuation of previous experiments in adult rats the alteration in content and composition of lung phospholipids (PL) and lung structure of newborn rats of different gestational age was studied after three administrations of the amphiphilic drugs imipramine (75 mg/kg b.w.) and chloroquine (50 mg/kg b.

[Animal experiments to determine the toxicity of mercury(II)-chloride in hemostasis].

In the course of an experimental poisoning of rats with mercury(II)-chloride no disturbances of haemostasis occurred, from which the development of a consumption coagulopathy might be concluded. Only a diminution of the plasminogen level could be found which is due to a moderate damage of liver parenchyme. The increased activity of the free form of the plasminogen activator found in the kidney homogenate is considered as an enzymatic activation because of kidney cell necrosis.

[Thrombogenicity of a new prothrombin complex concentrate].

A prothrombin complex concentrate produced according to a new procedure was tested for potential thrombogenicity in vitro and in vivo. The results obtained by in vitro methods (NAPTT, TGt50, determination of the hydrolytic index) were not in the critical range of thrombogenicity. An effective dose of 175 U/kg for thrombus formation assessed in the stasis model of Wessler suggested comparatively low thrombogenicity.

Imipramine and chloroquine induced alterations in phospholipid content of rat lung.

The influence of the amphiphilic drugs imipramine (150 mg/kg b. w./day) and chloroquine (75 mg/kg b.

[A comparative morphological and chemical study of the ambroxol and chlorphentermine action on the lung phospholipid content (author's transl)].

The influence of chronic administration of ambroxol on the phospholipid-(PL-) content and ultrastructure of lungs has been studied and compared with the effect of chlorphentermine (chlph.). Both drugs are amphiphilic substances.

[Liver alterations in newborn rabbits after maternal thrombin shock (author's transl)].

Intrauterine asphyxia has been induced in immature and mature newborn rabbits by means of experimental shock of the pregnant doe. Typical changes of clotting parameters and morphological alterations in different organs specific for shock were used as criteria of the maternal shock. For the detection of asphyxia conditioned neonatal organ lesions, liver, lung, kidney and heart muscle were studied light microscopically.

[Metastasising squamous-cell carcinoma of the skin in a ten-year-old girl].

Because of recurrent paronychia of the right thumb "granulation" tissue was removed from the nail-bed of a ten-year-old girl. Histological examination revealed a cornified squamous-cell carcinoma. About five months later a lymph-node metastasis was found in the right axilla.

Morphological and biochemical alterations of the lung after application of chlorphentermine.

The influence of short-term and chronic administration of chlorphentermine (Chlph) on the structure and phospholipid (PL)-content of the lungs was studied in guinea pigs. The drug was given daily in a dose of 40 mg per kg body weight i.p.

Lung alterations in newborn rabbits after maternal thrombin-shock. II. Lung phospholipids.

Alterations of the lung- and lung lavage fluid-phospholipids (PL's) after a maternal thrombin-shock have been studied in 1 and 5 h old newborn rabbits delivered at days 28 and 30 of gestation. In lung wash the amount of PL increases during the period of gestation and during the first hours of life. In asphyxiated mature animals the PL-content is statistically significantly decreased.

Lung alterations in newborn rabbits after maternal thrombin-shock. I. Morphological alterations.

Alterations of the lung structure, especially of the pneumocytes type II, of asphyxied newborn rabbits were investigated. Experiments were carried out on pregnant does shocked by thrombin- and Pamba-applications on the 28th, 29th and 30th day of gestation and on their newborns delivered by caesarian section at these days and killed after one or five hours life-time. Histologically, adult rabbits show characteristic alterations in an early phase of the shock.

[Lung alterations after paraquat poisoning (author's transl)].

After one application of paraquat (35 mg/kg body weight) studies of the changes in lung structure in phospholipid content of the alveolar wash as well as in the static pV-curves are performed on adult hooded rats. Pathomorphologically 2, 4, 8, 16, 24 and 48 h after the paraquat intoxication focal atelectases, circumscribed inflammatory infiltrations of the interstitium are predominant as well as an accumulation of macrophages in the interstitium and in the alveolar space. Initially granulocytes dominate in the inflammatory infiltrates; after 8 h lymphoid elements and histiocytes became more and more apparent.

[Experimental studies on disseminated intravascular coagulation (author's transl)].

Generalized disseminated intravascular coagulation (DIC) was produced in rats by thrombin infusion (550 NIH U thrombin/kg/h). Changes in the clotting system and morphological alterations were studied with consideration to early lesions. Furthermore, the influence of the antifibrinolytic agent Pamba and the fibrinolytic enzyme ocrase on DIC are studied.

[A case of central core disease. Electronmicroscopic studies (author's transl)].

A biopsy taken from the right m. gastrocnemius of a sporadic case of central core disease has been investigated by electronmicroscopy. Both longitudinal and cross sections show cores, which are partially in the centre and partially near the sarcolemma of the muscle fibres.

[A case of central core disease. Light microscopic and histochemical studies (author's transl)].

A sporadic case of central core disease in a 5 1/2-year-old girl is reported. Clinically, a retarded motor development existed, furthermore, a muscle weakness and hypotonia of the extremities and trunk, contractures of the hip- and knee-joint,and luxation of both hip-joints. Biopsy specimens are taken from both Mm.