Cyto-genotoxic effects predict ecotoxicity in plant bioassays and the aquatic organism L.: a case study from a sewage treatment plant.

This study evaluated the toxicological and mutagenic potential of water samples from a Wastewater Treatment Plant (WWTP) in Lavras, Minas Gerais, Brazil. Samples were taken from four sites: upstream in the stream (P1), downstream (P2), at the entrance of the treatment station (P3), and at the exit (P4). We conducted physicochemical analyses in water, phytotoxicity tests on plants (, , , ), cytogenotoxicity tests using onion roots (), and immobilization tests.

Detection dogs fighting transnational narcotraffic: performance and challenges under real customs scenario in Brazil.

Narcotic Detection Dogs (NDDs) are essential tools in the fight against drug trafficking, acting with high precision and improving efficiency at border posts. When trained efficiently, these dogs can detect a great variety of compounds, such as cocaine, marijuana and its derivatives, and synthetic drugs, among others. Most of the knowledge on canine detection processes and efficiency has been determined in experimentally controlled conditions, but narcotic seizures detected by dogs in realistic anti-drug operations have not yet been critically determined in a Country with continental dimensions such as Brazil.

Microcirculation and biomarkers in patients with resistant or mild-to-moderate hypertension: a cross-sectional study.

Microcirculation influences peripheral vascular resistance and therefore contributes to arterial blood pressure. The aim of this study was to investigate the correlation between serum markers of inflammation and microcirculatory parameters observed by nailfold videocapillaroscopy (NVC) in patients with resistant (RH, 58 [50-63] years, n = 25) or mild-to-moderate hypertension (MMH, 56 [47-64] years, n = 25) compared to normotensive patients (control group (CG), 33 [27-52] years, n = 25). C-reactive protein (CRP), endothelin, adiponectin, I-CAM and V-CAM levels were obtained by laboratory analysis.

Spironolactone Versus Clonidine as a Fourth-Drug Therapy for Resistant Hypertension: The ReHOT Randomized Study (Resistant Hypertension Optimal Treatment).

Unlabelled: The aim of this study is to compare spironolactone versus clonidine as the fourth drug in patients with resistant hypertension in a multicenter, randomized trial. Medical therapy adherence was checked by pill counting. Patients with resistant hypertension (no office and ambulatory blood pressure [BP] monitoring control, despite treatment with 3 drugs, including a diuretic, for 12 weeks) were randomized to an additional 12-week treatment with spironolactone (12.

Evaluation of endothelial function by VOP and inflammatory biomarkers in patients with arterial hypertension.

Hypertension is associated with microcirculatory impairment. Our objectives were to evaluate endothelial function and inflammatory biomarkers in patients with resistant (RH) and mild to moderate (MMH) arterial hypertension in comparison to normotensives (control group-CG). Three groups, 25 patients each, have been investigated, by anamnesis, venous occlusion plethysmography (VOP) and serum determination of adhesion molecules (VCAM, ICAM), adiponectin, endothelin and C-reactive protein (CRP).

APOE and LDLR Gene Polymorphisms and Dyslipidemia Tracking. Rio de Janeiro Study.

Background: Studies show an association between changes in apolipoprotein E (ApoE) and LDLR receptor with the occurrence of dyslipidemia.

Objectives: To investigate the association between polymorphisms of the APOE (ε2, ε3, ε4) and LDLR (A370T) genes with the persistence of abnormal serum lipid levels in young individuals followed up for 17 years in the Rio de Janeiro Study.

Methods: The study included 56 individuals (35 males) who underwent three assessments at different ages: A1 (mean age 13.

Blood pressure in adolescence, adipokines and inflammation in young adults. The rio de janeiro study.

Background: The impact of blood pressure (BP) during adolescence on other cardiovascular risk factors in young adults is important for the primary prevention.

Objective: To evaluate BP, anthropometric indexes, metabolic and inflammatory profiles in young individuals stratified by their BP behavior recorded for 18 years.

Methods: A total of 116 individuals, of whom 63 were males, from the Rio de Janeiro study (follow-up of 17.

Renal sympathetic denervation for resistant hypertension treatment : current perspectives.

The authors review the concept of resistant hypertension and the involvement of the sympathetic nervous system in hypertension as a rational basis for the technique of renal sympathetic denervation (RSD) performed percutaneously. This revision is the result of an active search for scientific articles with the term "renal denervation" in the Medline and PubMed databases. The techniques and devices used in the procedure are presented, as well as clinical outcomes at six, 12 and 24 months after the intervention with the Symplicity catheter.

Pulse wave velocity, blood pressure and adipocytokines in young adults: the Rio de Janeiro study.

Background: Data on noninvasive vascular assessment and their association with cardiovascular risk variables are scarce in young individuals.

Objective: To evaluate the association between pulse wave velocity and blood pressure, anthropometric and metabolic variables, including adipocytokines, in young adults.

Methods: A total of 96 individuals aged 26 to 35 years (mean 30.

Pulse wave velocity in young adults: study of Rio de Janeiro.

Background: Pulse wave velocity (PWV) can be a marker of cardiovascular impairment, but there are few studies in young adults.

Objective: To evaluate the association between blood pressure (BP), current anthropometric and metabolic variables and those obtained 13 years earlier, in childhood and adolescence, with PWV.

Methods: Sixty individuals were followed longitudinally and split into two groups according to the percentile of blood pressure (BP) obtained 13 years earlier: Group 1 (G1): BP percentile < 50 (n = 25, 11M, 26.

Association between uric acid and cardiovascular risk variables in a non-hospitalized population.

Background: The association between uric acid (UA) and cardiovascular risk variables remains a controversial issue in epidemiological studies.

Objective: To evaluate the association between UA, blood pressure (BP), anthropometric indices and metabolic variables in a non-hospitalized population stratified by UA quintiles.

Methods: A cross-sectional observational study evaluated 756 individuals (369 males), aged 50.

Metabolic syndrome, dyslipidemia, hypertension and type 2 diabetes in youth: from diagnosis to treatment.

Overweight and obesity in youth is a worldwide public health problem. Overweight and obesity in childhood and adolescents have a substantial effect upon many systems, resulting in clinical conditions such as metabolic syndrome, early atherosclerosis, dyslipidemia, hypertension and type 2 diabetes (T2D). Obesity and the type of body fat distribution are still the core aspects of insulin resistance and seem to be the physiopathologic links common to metabolic syndrome, cardiovascular disease and T2D.

Overweight and cardiovascular risk among young adults followed-up for 17 years: the Rio de Janeiro study, Brazil.

Background: The adoption of primary prevention measures among young people has a favorable impact on the context of cardiovascular diseases.

Objective: To assess blood pressure (BP) and cardiovascular risk variables among young adults stratified according to the body mass index (BMI) behavior obtained along 17 years, since childhood/adolescence (C/A).

Methods: Three assessments were carried out in 115 individuals pertaining to the study cohort of Rio de Janeiro, Brazil.

Importance of high-density lipoprotein-cholesterol (HDL-C) levels to the incidence of cardiovascular disease (CVD) in the elderly.

Studies about the impact of HDL-C levels on the incidence of cardiovascular disease (CVD) in the elderly are scarce. We decided to evaluate the relation of clinical and laboratory variables to the incidence of CVD events in the elderly stratified according to HDL-C behavior in an 8-year follow-up. We assessed 126 elderly (mean age: 70.

Blood pressure in young individuals as a cardiovascular risk marker. The Rio de Janeiro study.

Background: The study of the cardiovascular risk variables in young populations is fundamental to establish primary prevention strategies.

Objective: To evaluate the blood pressure (BP), anthropometric and metabolic profile in young individuals from The Rio de Janeiro Study, followed by 17 years.

Methods: A total of 115 individuals (64 males) were evaluated at three different moments (follow-up: 212.

Could pre-diabetes be considered a clinical condition? opinions from an endocrinologist and a cardiologist.

The prevalence of pre-diabetes is increasing worldwide and may start 7 to 10 years before the clinical diagnosis of diabetes. In this stage the presence and accumulation of risk factors is common and already implies an increase in cardiovascular risk. Likewise, the onset of cardiovascular diseases (CVD), mainly coronary artery disease (CAD), peripheral vascular disease and cerebrovascular disease can also take place, all of which account for high rates of morbidity and mortality worldwide.

Importance of HDL-c for the occurrence of cardiovascular disease in the elderly.

Background: Studies on the impact of HDL-c and the occurrence of cardiovascular disease (CV) in the elderly are scarce.

Objective: To evaluate the clinical and laboratory variables and the occurrence of CV events in elderly patients stratified according to the behavior of HDL-c during an eight-year follow up.

Methods: We evaluated 81 elderly patients, mean age of 68.

[Quality of data on the Child Health Record and related factors].

The Child Health Record (CHR) is an essential document for children's health care activities. A cross-sectional study was performed with simple random sampling, aimed at analyzing factors related to quality of data completion on the CHR. Interviews and direct verification of 365 CHRs from 9 health districts in Belo Horizonte, Minas Gerais State, Brazil, were performed.

Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes: the genetics, outcomes, and lipids in type 2 diabetes (GOLD) study.

The association of polymorphisms affecting lipid metabolism with the risk of myocardial infarction (MI) in type 2 diabetes mellitus was investigated. The Genetics, Outcomes and Lipids in type 2 Diabetes (GOLD) Study is a prospective, multicenter study, conducted on 990 patients presenting diabetes and MI (n=386), or diabetes without previous manifestation of stroke, peripheral or coronary arterial disease (n=604), recruited from 27 institutions in Brazil. APO A1 (A/G -75 and C/T +83) and APO C3 (C/G 3'UTR) non-coding sequences, CETP (Taq 1B), LPL (D9N), APO E (epsilon2, epsilon3, epsilon4,), PON-1 (Q192R), and two LCAT variants Arg(147)-->Trp and Tyr(171)-->Stop were tested by PCR-RFLP.

Management of metabolic syndrome in young population.

Metabolic syndrome is a complex disorder associated with several cardiovascular risk factors resulting in a 2.5-fold increase in cardiovascular mortality in adults. However, over the last 20 years, the same association has been demonstrated in the young population, and it is also related to a parental history of the syndrome.