Publications by authors named "MC Isaac"

Background: Point-of-care testing devices to measure haemoglobin (Hgb) frequently inform transfusion decision-making in surgery. This study aimed to examine their accuracy in surgery, focusing on Hgb concentrations of 60-100 g L, a range with higher potential for transfusion.

Methods: This was a prospective diagnostic cohort study focused on method comparison, conducted at two academic hospitals.

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Introduction: Long-term care (LTC) residents require extensive assistance with daily activities due to physical and cognitive impairments. Medical treatment for LTC residents, when not aligned with residents' wishes, can cause discomfort without providing substantial benefits. Predictive models can equip providers with tools to guide treatment recommendations that support person-centred medical decision-making.

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While the early mental health of girls and boys is similar, as children age, girls tend to report worse mental health than boys. Explanations for these gendered disparities remain elusive. This study seeks to understand the social context in which mental health experiences are shaped.

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Climate change is a public health emergency, yet planetary health education is absent for many medical and health professions trainees. To perform a scoping review exploring the inclusion of planetary health in undergraduate and graduate medical education. A search strategy was developed with a health sciences librarian and run on 6 databases from their inception to February 2022: MEDLINE, Embase, APA PsycInfo, CINAHL, Global Health, and Scopus.

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Background: Days at home after surgery is a promising new patient-centred outcome metric that measures time spent outside of healthcare institutions and mortality. The aim of this scoping review was to synthesize the use of days at home in perioperative research and evaluate how it has been termed, defined, and validated, with a view to inform future use.

Methods: The search was run on MEDLINE, Embase, and Scopus on 30 March 2023 to capture all perioperative research where days at home or equivalent was measured.

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Purpose: Postoperative prognostic tools allow for improved prediction of future recurrence risk, patient counseling, and assessment of eligibility for adjuvant treatments and ensure appropriate follow-up surveillance. The purpose of this analysis was to validate existing prognostic models for patients with kidney cancer.

Materials And Methods: The Canadian Kidney Cancer information system is a prospective cohort of patients managed at 14 institutions since January 1, 2011, to present.

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Carbon capture can mitigate point-source carbon dioxide (CO) emissions, but hurdles remain that impede the widespread adoption of amine-based technologies. Capturing CO at temperatures closer to those of many industrial exhaust streams (>200°C) is of interest, although metal oxide absorbents that operate at these temperatures typically exhibit sluggish CO absorption kinetics and instability to cycling. Here, we report a porous metal-organic framework featuring terminal zinc hydride sites that reversibly bind CO at temperatures above 200°C-conditions that are unprecedented for intrinsically porous materials.

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Introduction: Home-based, virtually-supported care models may represent the most efficient and scalable approach to delivering prehabilitation services. However, virtual approaches to prehabilitation are understudied. This manuscript describes the protocol for an internal pilot randomised controlled trial of a virtually-delivered, multimodal prehabilitation intervention.

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Aquatic habitats in urban environments are exposed to complex contaminant mixtures that may harm aquatic biota. The impact of contaminant transfer from contaminated biofilm through aquatic food webs is still understudied, as is the current state of knowledge on dietary exposure of urban contaminants to biota residing in stormwater ponds. Our overall objective was to characterize urban pesticide accumulation in a common aquatic food source (biofilm) in stormwater ponds and to investigate the potential toxicity of that food source by testing the responses of two freshwater macroinvertebrates to experimental exposure.

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Purpose: Northern Ontario residents experience multiple health disparities compared with those in Southern Ontario. It is unknown whether this leads to differences in surgical outcomes. We sought to compare postoperative outcomes of patients from Northern and Southern Ontario.

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Article Synopsis
  • The study investigates whether living in rural areas affects mortality rates in patients with acute myocardial infarction (AMI) and heart failure (HF), which may impact healthcare access and outcomes.
  • A meta-analysis of 37 studies was conducted, encompassing over 21 million AMI patients and nearly 18 million HF patients, to compare rural versus urban patient mortality, focusing on all-cause mortality.
  • Results indicate that although rural AMI patients are slightly older and have a higher proportion of females, the analysis aims to provide insights into mortality differences and the factors that may contribute to any observed disparities between rural and urban populations.
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Purpose: While there is limited patient-centred evidence (i.e., evidence that is important for patients and end-users) to inform the use of pharmacologic opioid minimization strategies (i.

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  • Regulatory applications for cell therapies face more objections than traditional drugs, primarily due to inadequacies in preclinical evidence like study design and animal model selection, causing delays in approvals.
  • A scoping review of 1215 documents from major regulatory agencies identified 182 relevant papers, highlighting the critical role of understanding the mechanism of action in preclinical studies.
  • While most guidelines stressed using clinically relevant preclinical models and intervention parameters, there were fewer specific recommendations on disease models and proper study designs like randomization and blinding.
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is a ubiquitous bacterium and opportunistic pathogen for immunocompromised patients. Peritoneal dialysis-related peritonitis is a rare clinical presentation, with a total of 23 cases reported to date and an overall mortality rate of 17.3%.

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Objective: Early learning and childcare (ELCC) programmes play an important role in shaping children's eating behaviours and long-term health by establishing a responsive feeding environment that encompasses not only mealtime behaviours but also extends to play activities and language used throughout the day. Despite their potential benefits, many ELCC centres do not consistently implement responsive feeding behaviours, facing challenges with organisational and behavioural changes within these environments. This study aims to identify influences on responsive feeding behaviours among early childhood educators prior to an intervention.

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Objectives: Although surgical site infection (SSI) is a commonly used quality metric after lower-limb revascularization surgery, outcomes associated with development of this complication are poorly characterized. We conducted a systematic review and meta-analysis of studies reporting associations between development of an SSI after these procedures and clinical outcomes and healthcare resource use.

Methods: We searched MEDLINE, Embase, CENTRAL, and Evidence-Based Medicine Reviews (inception to April 4th, 2023) for studies examining adjusted associations between development of an SSI after lower-limb revascularization surgery and clinical outcomes and healthcare resource use.

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  • Patients undergoing open radical cystectomy have a high risk of needing blood transfusions, and the study investigates the use of tranexamic acid (TXA) to potentially reduce this risk.
  • The TACT trial was a randomized, double-blind study conducted in 10 academic centers from 2013 to 2021, involving patients scheduled for this type of surgery due to bladder cancer.
  • Results showed no significant difference in RBC transfusion rates between the TXA group and the placebo group, with both groups needing transfusions at similar rates up to 30 days post-surgery.
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  • The study focused on whether a home-based exercise program combined with nutritional guidance (prehabilitation) improves disease-free survival and return to treatment for older cancer patients with frailty compared to usual care.* -
  • Out of 204 participants, results showed that the prehabilitation group and control group had similar rates of death or cancer recurrence (11% each), and slightly more patients returned to treatment in the prehabilitation group (29% vs. 23%).* -
  • Ultimately, the research found no significant advantage of exercise prehabilitation on disease-free survival or treatment return, suggesting that future studies may need to be larger to detect meaningful effects.*
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  • Frailty in elderly patients is linked to higher rates of morbidity and mortality post-surgery, and its relationship with decisional regret (the feeling of regret about undergoing surgery) is not well understood.
  • A study of 669 patients aged 65 and older undergoing elective noncardiac surgery found that 43.8% lived with frailty, and while frailty was initially related to increased decisional regret one year after surgery, this association weakened after adjusting for other factors like age, sex, and mental health.
  • The results indicated that the type of surgery may influence the relationship between frailty and decisional regret, suggesting that more research is needed to fully understand these connections.
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