[Chemical simulations of quantum systems using quantum computers - review of algorithms and their experimental verification].

Computer simulations using ever-increasing computing power and machine learning techniques allow advanced molecular modelling, molecular dynamics simulations and studies of intermolecular interactions. However, due to the complexity of biological systems and chemical processes at the molecular level, their accurate representation using classical computer models and techniques has faced a number of significant limitations for many years. A new and promising direction for the development of computational science and its potential applications in biochemistry is quantum computing and its integration with classical high-performance supercomputing systems.

Low neurocognitive performance and problematic contexts: interaction influences in predicting adolescent externalizing behaviors within a community sample.

Research has identified neurocognitive and contextual risk factors of externalizing behaviors. However, fewer studies have examined the interaction among neurocognitive and other risk factors in predicting externalizing behaviors. The goal of the current study was to examine the relation between neurocognitive and contextual factors in predicting externalizing behaviors in a community sample of adolescents.

Inter-Segment Coordination of Male and Female Collegiate Ice Hockey Players During Forward Skating Starts.

: Coordination in ice hockey skating has been minimally investigated, particularly in females. The objective was to compare lower-extremity inter-segment coordination of collegiate male and female ice hockey players during forward skating starts. : 3D kinematic data were collected on collegiate male ( = 9) and female ( = 10) participants during accelerative steps.

B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S.

The viral vector-based COVID-19 vaccine Ad26.COV2.S has been recommended by the WHO since 2021 and has been administered to over 200 million people.

Waning immunity and IgG4 responses following bivalent mRNA boosting.

Messenger RNA (mRNA) vaccines were highly effective against the ancestral SARS-CoV-2 strain, but the efficacy of bivalent mRNA boosters against XBB variants was substantially lower. Here, we show limited durability of neutralizing antibody (NAb) responses against XBB variants and isotype switching to immunoglobulin G4 (IgG4) responses following bivalent mRNA boosting. Bivalent mRNA boosting elicited modest XBB.

Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86.

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant BA.2.86 has over 30 mutations in spike compared with BA.

SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice.

We report the direct comparison of monomeric, dimeric and trimeric RBD protein subunit vaccines to a virus-like particle (VLP) displaying RBD. After two and three doses, a RBD dimer and trimer elicited antibody levels in mice comparable to an RBD-VLP. Furthermore, an Omicron (BA.

Ad26.COV2.S and SARS-CoV-2 spike protein ferritin nanoparticle vaccine protect against SARS-CoV-2 Omicron BA.5 challenge in macaques.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines demonstrate reduced protection against acquisition of BA.5 subvariant but are still effective against severe disease. However, immune correlates of protection against BA.

Waning Immunity Against XBB.1.5 Following Bivalent mRNA Boosters.

The SARS-CoV-2 Omicron variant has continued to evolve. XBB is a recombinant between two BA.2 sublineages, XBB.

Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters.

Waning immunity following mRNA vaccination and the emergence of SARS-CoV-2 variants has led to reduced mRNA vaccine efficacy against both symptomatic infection and severe disease. Bivalent mRNA boosters expressing the Omicron BA.5 and ancestral WA1/2020 Spike proteins have been developed and approved, because BA.

Endoluminal larynx anatomy model - towards facilitating deep learning and defining standards for medical images evaluation with artificial intelligence algorithms.

The pioneering nature of this work covers the answers to two questions: (1) Is an up-to-date anatomical model of the larynx needed for modern endoscopic diagnostics, and (2) can such a digital segmentation model be utilized for deep learning purposes. The idea presented in this article has never been proposed before, and this is a breakthrough in numerical approaches to aerodigestive videoendoscopy imaging. The approach described in this article assumes defining a process for data acquisition, integration, and segmentation (labeling), for the needs of a new branch of knowledge: digital medicine and digital diagnosis support expert systems.

Straightforward -Acyl Homoserine Lactone Discovery and Annotation by LC-MS/MS-based Molecular Networking.

-Acyl-l-homoserine lactones (AHLs) are a large family of signaling molecules in "quorum sensing" communication. This mechanism is present in a number of bacterial physiological phenomena, including pathogenic phenomena. In this study, we described a simple and accessible way to detect, annotate, and quantify these compounds from bacterial culture media.

Comparing recidivism rates among domestically violent men enrolled in ACTV versus Duluth/CBT.

The goal of the present study was to replicate and extend published preliminary evidence demonstrating that a relatively new treatment (Achieving Change through Value-Based Behavior [ACTV]) for men convicted of domestic violence significantly reduces recidivism compared to the standard treatment offered across the United States (the Duluth Model and/or cognitive-behavioral approaches). Men convicted of domestic assault (DA) and court-mandated to a Batterers Intervention Program [ = 725; = 34.9 years ( = 10.

Differences in inter-segment coordination between high- and low-calibre ice hockey players during forward skating.

The objective was to compare lower extremity inter-segment coordination between high-calibre and low-calibre ice hockey players during forward full stride skating. A 10-camera Vicon motion capture system collected kinematic data on male high-calibre (n = 8) and low-calibre (n = 8) participants. Continuous relative phase (CRP) was calculated for shank-/thigh, shank-s/thigh- and foot-/shank- segment pairs.

Measures for interoperability of phenotypic data: minimum information requirements and formatting.

Background: Plant phenotypic data shrouds a wealth of information which, when accurately analysed and linked to other data types, brings to light the knowledge about the mechanisms of life. As phenotyping is a field of research comprising manifold, diverse and time-consuming experiments, the findings can be fostered by reusing and combining existing datasets. Their correct interpretation, and thus replicability, comparability and interoperability, is possible provided that the collected observations are equipped with an adequate set of metadata.

Do we need a new classification of parotid gland surgery?

Background: In February 2016 the European Salivary Gland Society (ESGS) presented and recommended classification of parotidectomies based on the anatomical I-V level division of parotid gland. The main goal of this paper is to present the new classification, and to answer the question if it is more precise compared to classic one.

Material And Method: 607 patients (315 man, 292 women) operated on for parotid tumours in a tertiary referral centre, Department of Otolaryngology, Head and Neck Surgery, Medical University of Poznań (502 benign and 105 malignant tumours).

[A patient with Churg-Strauss syndrome presenting as Guillain-Barré syndrome].

A 74-year-old man presented in a pulmonary clinic with symmetrically ascending tetraparesis. Physical and neurophysiological examinations suggested Guillain-Barré syndrome. The patient was treated with an initial course of 7s immunoglobulins without success.

Grid-supported Medical Digital Library.

Secure, flexible and efficient storing and accessing digital medical data is one of the key elements for delivering successful telemedical systems. To this end grid technologies designed and developed over the recent years and grid infrastructures deployed with their use seem to provide an excellent opportunity for the creation of a powerful environment capable of delivering tools and services for medical data storage, access and processing. In this paper we present the early results of our work towards establishing a Medical Digital Library supported by grid technologies and discuss future directions of its development.