An inhibitory segment within G-patch activators tunes Prp43-ATPase activity during ribosome assembly.

Mechanisms by which G-patch activators tune the processive multi-tasking ATP-dependent RNA helicase Prp43 (DHX15 in humans) to productively remodel diverse RNA:protein complexes remain elusive. Here, a comparative study between a herein and previously characterized activators, Tma23 and Pxr1, respectively, defines segments that organize Prp43 function during ribosome assembly. In addition to the activating G-patch, we discover an inhibitory segment within Tma23 and Pxr1, I-patch, that restrains Prp43 ATPase activity.

High-Resolution Phase-Based Ranging Using Inverse Fourier Transform in an Iterative Bayesian Approach.

This article proposes an algorithm that determines the distance between two transceivers based on phase information collected in a specific frequency range. Even though we have focused on BLE technology, we do not necessarily adhere strictly to this standard regarding the procedures used to obtain phased samples. We assume that phase samples are given and propose an algorithm using a Bayesian approach to find delays in a multi-path environment.

Changes in body weight in various population groups in Poland during the COVID-19 pandemic - a comparison of two cross-sectional studies.

Introduction And Objective: The disruption of daily activities caused by the COVID-19 pandemic had health consequences, especially during peak lockdown periods. The aim of the study is to assess the impact of the first year of the COVID-19 pandemic on the process of weight change among Polish adults.

Material And Methods: Two representative studies involving Polish adults aged 18-65 years were conducted, the first in June 2020 (N = 2527, from the perspective of the last 2-3 months), and the second a year later, in June 2021 (N = 2087, covering the last 12 months).

Influence of Human Activity on Radon Concentration, Indoor Air Quality, and Thermal Comfort in Small Office Spaces.

This article focuses on the influence of occupants on the concentration of contaminants (radon Rn-222 and CO) as well as the thermal comfort parameters. A series of sensors were placed to measure the concentration of the contaminants, temperature, and relative humidity in the test room at the Institute of Nuclear Physics PAN in Krakow (IFJ PAN), Poland. The test room is an office that is typical of the offices used in the facility.

Racial Disparities in Clinical Outcomes of Takotsubo Cardiomyopathy: An Analysis of the National Inpatient Sample 2006 to 2018.

Background: This study aimed to evaluate the impact of race on in-hospital outcomes of Takotsubo cardiomyopathy using the National Inpatient Sample.

Methods And Results: We conducted a retrospective study using data from the National Inpatient Sample database 2006 to 2018. We focused on Takotsubo cardiomyopathy hospitalizations, excluding those with acute coronary syndrome as the primary diagnosis.

Body weight and assessment of sexual life - a cross-sectional study.

Introduction And Objective: Body weight can be one of the health effects affecting people's well-being in its many aspects. The aim of the study was to assess the relationship between body weight and sexual life.

Material And Methods: In June 2020 a survey was conducted online on a nationwide representative group of 3,000 Poles.

Frictional Properties of Soaps with the Addition of Ground Hazelnut Shells.

The search for new technologies and related new biological materials for use in the cosmetics industry requires many studies and analyses of not only chemical but also physical properties. This study attempts to assess the properties of soap produced with the addition of crushed hazelnut shells. This additive is intended to improve the friction properties of the soap, which in turn enhances the quality of removing impurities from the skin.

[Polish version of the questionnaire for measuring post-traumatic stress disorders PTSD-8 in studies of four groups of medical professions].

Background: There are several techniques to diagnose post-traumatic stress disorder (PTSD) symptoms that correspond to the (DSM) classification of mental disorders. This study aimed at testing the reliability and construct validity of the Polish version of the PTSD-8. The results obtained in four professional groups of healthcare workers (physicians, nurses, paramedics, other occupations) were compared.

Genome-wide identification, phylogenetic classification of histone acetyltransferase genes, and their expression analysis in sugar beet (Beta vulgaris L.) under salt stress.

This study identified seven histone acetyltransferase-encoding genes (HATs) from Beta vulgaris L. (sugar beet) genome through bioinformatics tools and analyzed their expression profiles under salt stress. Sugar beet HATs are phylogenetically divided into four families: GNAT, MYST, CBP, and TAFII250.

Colonization of by human pathogenic microorganisms.

Contamination of vegetables with human pathogenic microorganisms (HPMOs) is considered one of the most important problems in the food industry, as current nutritional guidelines include increased consumption of raw or minimally processed organic vegetables due to healthy lifestyle promotion. Vegetables are known to be potential vehicles for HPMOs and sources of disease outbreaks. In this study, we tested the susceptibility of radish () to colonization by different HPMOs, including PCM 2561, subsp.

Retrospective, multicenter analysis of the safety and effectiveness of direct oral anticoagulants for the treatment of venous thromboembolism in obesity.

Background: Direct oral anticoagulants (DOACs) are the preferred treatment for venous thromboembolism (VTE). However, DOAC use in patients with a BMI greater than 40 kg/m has not been well studied despite the growing prevalence of obesity, and current literature is often underpowered.

Methods: This multicenter, retrospective, observational study evaluated patients 18 years and older who received DOACs for acute VTE treatment.

Risk stratification in patients with structurally normal hearts: Does fibrosis type matter?

Objectives: The study sought to assess the prognostic significance of nonischemic myocardial fibrosis (MF) on cardiovascular magnetic resonance (CMR)-both macroscopic MF assessed by late gadolinium enhancement (LGE) and diffuse microscopic MF quantified by extracellular volume fraction (ECV)-in patients with structurally normal hearts.

Background: The clinical relevance of tissue abnormalities identified by CMR in patients with structurally normal hearts remains unclear.

Methods: Consecutive patients undergoing CMR were screened for inclusion to identify those with LGE imaging and structurally normal hearts.

Dr. Allen Oldfather Whipple (1881-1963): Namesake of the pancreaticoduodenectomy.

Allen O. Whipple was an American surgeon who popularized the pancreaticoduodenectomy (Whipple procedure) for periampullary cancer, which remains the gold standard for pancreatic tumor resections. Whipple was educated at Princeton University (B.

RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing.

The conserved SR-like protein Npl3 promotes splicing of diverse pre-mRNAs. However, the RNA sequence(s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 during the splicing reaction remain elusive. Here, we developed a split-iCRAC approach in yeast to uncover the consensus sequence bound to each RRM.

The development and cross-national validation of the short health literacy for school-aged children (HLSAC-5) instrument.

Health literacy is an asset for and indicator of adolescents' health and wellbeing, and should therefore be monitored and addressed across countries. This study aimed to develop and validate a shorter version of the original 10-item health literacy for school-aged children instrument in a cross-national context, using data from the health behaviour in school-aged children 2017/18 survey. The data were obtained from 25 425 adolescents (aged 13 and 15 years) from seven European countries.

An engineered A549 cell line expressing CD13 and TMPRSS2 is permissive to clinical isolate of human coronavirus 229E.

The lack of suitable in vitro culture model has hampered research on wild-type (WT) human coronaviruses. While 3D tissue or organ cultures have been instrumental for this purpose, such models are challenging, time-consuming, expensive and require extensive cell culture adaptation and directed evolution. Consequently, high-throughput applications are beyond reach in most cases.

Quality of life in 13-year-olds depending on health status, residential neighbourhood deprivation and social capital - results from the Polish HBSC Study 2010-2018.

Introduction And Objective: Health-related quality of life (HRQL) should be used more extensively in monitoring the health of school-aged children. The presented study aimed to evaluate trends in KIDSCREEN-10 indices, considering mean scores and the level of social inequalities.

Material And Methods: 3,937 children aged 13 participated in three Health Behavior in School-aged Children (HBSC) cross-sectional surveys conducted in Poland between 2010-2018.

Experimental investigation of the responses of meadow buttercup (Ranunculus acris L.) to sodic salinity and its implications for habitat monitoring.

Ranunculus acris L. is a native species widely distributed throughout Europe and is invasive in nonnative areas, causing substantial economic losses in pasture productivity. The present study examined the effects of sodic salinity on the growth and functioning of this species.

We Care: A Wellness Intervention Project for Palliative Care Physicians.

There is a trend toward burnout in palliative care physicians. Due to this, a five-session curriculum has been designed with resiliency tools, coping skills, and spirituality in order to train palliative care fellows in an inpatient setting. More research is needed on this curriculum, but preliminary findings have shown a positive response.

Online Correction of Laser Head Nozzle Position for Laser Metal Deposition Using a Chromatic Confocal Displacement System.

The stability and repeatability of laser metal deposition is particularly important when processing multiple layers or depositing material on complex component surfaces, and requires the use of process parameter control including the stand-off distance between the laser head and the substrate. The system proposed in this paper for correcting the stand-off parameter is based on a chromatic confocal sensor integrated into a laser head. Then, the spectral signal acquired from the measurement system is processed by using the developed application to compensate for the movement of an additional axis of the kinematic system.