Effect of VBIT-4 on the functional activity of isolated mitochondria and cell viability.

VBIT-4 is a new inhibitor of the oligomerization of VDAC proteins of the outer mitochondrial membrane preventing the development of oxidative stress, mitochondrial dysfunction, and cell death in various pathologies. However, as a VDAC inhibitor, VBIT-4 may itself cause mitochondrial dysfunction in healthy cells. The article examines the effect of VBIT-4 on the functional activity of rat liver mitochondria and cell cultures.

Mitochondrial Dyshomeostasis as an Early Hallmark and a Therapeutic Target in Amyotrophic Lateral Sclerosis.

Amyotrophic lateral sclerosis (ALS) is a fatal multisystem disease characterized by progressive death of motor neurons, loss of muscle mass, and impaired energy metabolism. More than 40 genes are now known to be associated with ALS, which together account for the majority of familial forms of ALS and only 10% of sporadic ALS cases. To date, there is no consensus on the pathogenesis of ALS, which makes it difficult to develop effective therapy.

[Methods of art therapy in psychogerontological practice.].

The article deals with the use of art-therapeutic methods in the complex psychological support of the elderly and senile age. The study was conducted on the basis of the Comprehensive Center of Social Services for the Population of the Birsk District and the City of Birsk of the Republic of Bashkortostan and Polyclinic № 1 of Ufa, total sample was 60 respondents aged 60-80 years. The analysis of the results revealed that the use of the art therapy program with the gradual enrichment and complication of art therapy classes stimulates new life orientations, the awareness of the individual of the presence of other psychological characteristics that allow the subject to function successfully in real life.

[Total revascularization of the lower limb in a patient with multifocal atherosclerosis and critical ischaemia].

Described in the article is a clinical case report regarding revascularization of the entire arterial bed of the lower extremity in a male patient presenting with multifocal atherosclerosis, stenoses of the arteries of the iliofemoral segment, occlusions of the superficial femoral artery, popliteal artery and arteries of the crus. Clinically, the patient was diagnosed as having critical ischaemia of the lower limb with wet necrosis of the toes. The patient simultaneously underwent semiclosed loop endarterectomy from the arteries of the femoropopliteal segment with the help of the Vollmar rings, autovenous popliteal-tibial prosthetic repair, as well as exarticulation of the toes.

Interrelation secretory activity of stomach and immunes changes of peripheral blood when ulcerogenesis stomach.

Unlabelled: Incidence of gastric ulcer is high in almost all countries of the world. On the development and course of the disease affect the state acid- and enzymes production stomach, immune status. The purpose was to determine the presence and power of correlative links secretory activity of the stomach and immune changes in the peripheral blood during exacerbation of ulcer disease stomach.

[GENDER FEATURES CHANGES OF MICROBIOTA GASTRIC AT DISEASES GASTRODUODENAL ZONE].

The aim of the study was to examine changes in the microbiota gastric an diseases gastroduodenal zone to highlight gender features. We examined patients at esophagogastroduodenoscopy performed biopsies mucous membrane fence with the wall mucus, followed by microscopic, microbiological, histological examination. When polyposis and gastric cancer incidence in women H.

[The mode of prognosis course of gastric ulcer].

The stomach ulcer is widely spread and is characterized by dangerous and now and then lethal complications. The study was carried out to develop mode of prognosis of course of stomach ulcer. The complex examination of 40 healthy volunteers (control group) and 42 patients with stomach ulcer (main group)was implemented.

[Detection of the markers of herpesvirus infections in stomach diseases of inhabitants of the Republic of Mordovia].

The study included 120 patients with pre-cancer conditions of the stomach and 30 patients with gastric cancer stage II-IV. The ELISA method in the blood serum was used to determine the markers of the infection caused by Herpes simplex virus (HSV) types 1 and 2, Cytomegalovirus (CMV), and Epstein-Barr virus (EBV). The majority of the patients exhibited high titers of markers of Herpesvirus mixed infection.

[The changes in serum concentrations of interleukin-17 in diseases gastroduodenal zone].

The Purpose Of The Study: Identify on patients with chronic gastritis, peptic ulcer disease, gastric cancer, serum concentrations of interleukin-17 and its relationship to clinical and morphological and serological characteristics.

Material And Methods: A comprehensive survey of 156 patients with diseases gastroduodenal zone. Diagnostic emphasis was placed on ELISA method as defined in the serum of IL-17, pepsinogen-I, - II, total antibodies to CagA Helicobacter pylori.

[Serum interleukin-18 level in precancerous conditions and gastric cancer].

Unlabelled: The purpose of the study--to determine the serum concentration and the pathogenetic significance of changes of interleukin-18 in patients with chronic atrophic gastritis, peptic ulcer disease and gastric cancer. MATERIAL AND METHODS.:A comprehensive survey of 192 patients with diseases gastroduodenal zone.

[The role of interleukin-1 and associated cytokines in gastric carcinogenesis].

This review presents detailed analysis of scientific data on influence of the associated with interleukin-1 cytokines on the development of malignant tumors of stomach with the definition of spectrum of diagnostic and therapeutic possibilities. Cytokines associated with interleukin-1 directly and indirectly involved into gastric carcinogenesis. Implementation of pro- and contreoncogenic effects depends on many factors.

[Prevalence of smoking in Izhevsk].

The purpose of the investigation was to study the prevalence of smoking as the most aggressive risk factor of chronic obstructive pulmonary disease in different populations of a large industrial center. A questionnaire survey was conducted in 485 schoolchildren, 427 students, and 1406 adults from Izhevsk. The smoking rates were 73.

[Peculiarities of stress erosive ulcerous injuries of stomach and small intestine].

Aim: The aim of this investigation is to estimate the role of systemic injuries of lipid metabolism in pathogenesis of ulceration on the model of stress ulcerogenesis.

Materials And Methods: There have been assumed as a basis of the work experimental investigations on 60 pubertal white rats of both sexes weighing 200 gr. There was studied the state of macroscopic picture of stomach and small intestine, qualitative and quantitative lipid composition, lipid peroxidation, phospholipase A2, catalase, superoxide dismutase in stomach tissues, small intestine and blood plasma.

The use of anaferon (pediatric formulation) for prophylaxis of acute respiratory viral infections in preschool children.

Anaferon (pediatric formulation) reduces the incidence of acute respiratory viral infections in sickly children and children with bronchial asthma and has a positive effect on the course of asthma. The preparation produces an immunomodulating effect (increases initially low IFN-gamma levels and normalizes elevated levels of IL-1beta), stimulates synthesis of IgA and IgG, exhibits cytoprotective activity, and improves local immunity of the upper airways in sickly children.

[Intensive physical conditioning as nonspecific prophylaxis of respiratory diseases in children].

We studied efficacy of using intensive physical conditioning as prophylaxis of respiratory diseases in young children and health status of children exposed to physical conditioning in childhood (a total of 44 children aged from 1.5 months to 1 year; 58 children aged from 2.5 to 13.

[Disturbance of immune characteristics of the mucous membranes of the respiratory tract in bronchopulmonary diseases in children].

A total of 100 children with bronchopulmonary diseases were examined. Of these, in 80 bronchial asthma and in 20 children acute pneumonia were diagnosed. The deficiency of local cell mediated and humoral factors on the mucous membranes of the upper respiratory tracts was established.

Integration of mass spectrometry into early-phase discovery and development of central nervous system agents.

The early-phase discovery and development of useful central nervous system (CNS) agents present ample opportunities to exploit mass spectrometry and provide detailed compound/mixture characterization, or to make the process faster and/or more economic. Neuropeptide FF antagonists and centrally active thyrotropin-releasing hormone analogues were used as specific examples in this work. We evaluated the characterization of focused libraries of peptide derivatives by electrospray ionization, tandem mass spectrometry and liquid chromatography/tandem mass spectrometry on a quadrupole ion trap and nanoelectrospray on a Fourier transform ion cyclotron resonance mass spectrometer.

The missing organic molecules on Mars.

GC-MS on the Viking 1976 Mars missions did not detect organic molecules on the Martian surface, even those expected from meteorite bombardment. This result suggested that the Martian regolith might hold a potent oxidant that converts all organic molecules to carbon dioxide rapidly relative to the rate at which they arrive. This conclusion is influencing the design of Mars missions.

[The use of an aerosol of natural brine and of sinusoidal modulated currents in chronic pneumonias in children].

Inhalations of 1% natural brine in combination with SMC electrophoresis of 1% natural brine above the lesion proved to ensure good correction of the defense of respiratory tract mucosa and to prolong remission to 15-18 months. This method can be applied in sanatoria, in rehabilitation centers, in pulmonary disease departments.

[The effect of intensive conditioning on the child's body resistance].

Intensive conditioning significantly stimulates defensive factors of local and systemic immunity and aroused levels of stress hormones. In initial deficient resistance intensive training causes exhaustion of defensive reserves of child's body.

[Thermal vibromassage in the treatment of children with dyskinesia of the biliary tract].

Combined use of tubage with 2% solution of natural agent Shirsal and thermovibromassage of the right hypochondrium area for biliary dyskinesia promotes normalization of biliary system motility. The course of the procedures enhances the positive clinical trend and induces remission which persists for 6-8 months.

[An alternative model of structural organization of the ternary complex antigen-protein MHC II-TCR].

An alternative model of organization of the structure of ternary complex "antigen-molecule" of the main complex of histocompatible class II (MHC II)--antigenic receptor of T-cells (TCR) is suggested. In contrast to the already developed ones the new model foresees TCR interaction with only one (beta)-chain of the molecule MHC (II), with its surface site having the structure of alpha-spiral. The second (alpha)-chain of the molecule MHC II performs only antigen-binding and supporting function.

[Tn5-mutagenesis of the styrene-degrading strain Pseudomonas sp. Y2. Analysis of transformation products and DNA-scopy of the mutants obtained].

The bacterium Pseudomonas sp. Y2 using styrene as a sole source of carbon and energy was subjected to transposon Tn5(Kmr) mutagenesis. The mutants were divided into three classes by the ability to grow on styrene, 2-phenylethanol, and phenylacetate.