Senolytic Vaccines from the Central and Peripheral Tolerance Perspective.

Preventive medicine has proven its long-term effectiveness and economic feasibility. Over the last century, vaccination has saved more lives than any other medical technology. At present, preventative measures against most infectious diseases are successfully used worldwide; in addition, vaccination platforms against oncological and even autoimmune diseases are being actively developed.

Dataset of human platelets SERS spectra from individuals with acute coronary syndrome.

This article contains Raman experimental data, obtained by means of Centaur U («NanoScanTechnology», Russia) Raman spectrometer, which was used for early structure changes and biomarkers identification in individuals with cardiovascular pathology . The data include analyzed Raman spectra of human platelets taken from individuals with acute coronary syndrome.

T-cell immunity against senescence: potential role and perspectives.

The development of age-associated diseases is related to the accumulation of senescent cells in the body. These are old non-functional cells with impaired metabolism, which are unable to divide. Such cells are also resistant to programmed cell death and prone to spontaneous production of some inflammatory factors.

Determination of Anthracene Derivatives in Baltic Amber Using SERS.

The article describes the results of Raman spectroscopy and SERS for the study of fluorescent components of Baltic amber via the extraction method. Using SERS, it was possible to confirm the presence of anthracene derivatives in amber: tetracene and benzanthracene. It has been shown that SERS methods are effective for the detection of aromatic compounds; they increase the registered Raman signal and make it possible to identify peaks characteristic of the compounds under study.

Spectral homogeneity of human platelets investigated by SERS.

This paper describes a detailed study of the spectral homogeneity of human platelets using Surface-enhanced Raman spectroscopy (SERS). We used a combined approach based on multivariate methods as principal component analysis and pair correlation algorithms to investigate platelets spectral properties. The correlation coefficients for each sample have been calculated, and the average coefficient of determination has been estimated.

Spectral and time-resolved photoluminescence of human platelets doped with platinum nanoparticles.

This paper describes a detailed study of spectral and time-resolved photoprocesses in human platelets and their complexes with platinum (Pt) nanoparticles (NPs). Fluorescence, quantum yield, and platelet amino acid lifetime changes in the presence and without femtosecond ablated platinum NPs have been studied. Fluorescence spectroscopy analysis of main fluorescent amino acids and their residues (tyrosine (Tyr), tryptophan (Trp), and phenylalanine (Phe)) belonging to the platelet membrane have been performed.

Numerical FDTD-based simulations and Raman experiments of femtosecond LIPSS.

The article describes the results of finite-difference time-domain (FDTD) mathematical modeling of electric field strength distribution near the gold laser-induced periodic surface structures (LIPSS). Both theoretical and experimental results have been described for two fabricated morphologies: round «hill-like» and grating structures. The structures were fabricated by using a femtosecond Yb-fiber laser with a wavelength of λ=1032 nm, pulse duration τ=280 fs, and repetition rate υ=25 kHz.

Dataset of human platelets in healthy and individuals with cardiovascular pathology obtained by surface-enhanced Raman spectroscopy.

This data article contains Raman experimental data, obtained with Centaur U Raman spectrometer (Russia), which can be used for rapid and early structure changes and biomarkers identification in individuals with cardiovascular decease (CVD) pathology . The data include analyzed Surface-Enhanced Raman Scattering (SERS) spectra of human platelets taken from healthy individuals and individuals with cardiovascular pathology. Data can provide information about characteristic maxima of different cell components and its changes in platelets.