Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Mali: a systematic review and meta-analysis.

Background: Artemisinin-based combination therapy (ACT) was deployed in 2005 as an alternative to chloroquine and is considered the most efficacious treatment currently available for uncomplicated falciparum malaria. While widespread artemisinin resistance has not been reported to date in Africa, recent studies have reported partial resistance in Rwanda. The purpose of this study is to provide a current systematic review and meta-analysis on ACT at Mali study sites, where falciparum malaria is highly endemic.

The prevalence of sight impairment registration post-stroke.

Many stroke survivors are eligible for sight impairment (SI) registration from a chronic visual impairment (VI). The literature and clinical experience show that some individuals who meet the criteria for registration either decline or are not offered registration. The aim of this Orthoptic stroke service review is to determine the reason for declining and whether the individuals feel supported without registration and to recommend service changes to improve the certification process.

A cross-sectional survey assessing the preparedness of the long-term care sector to respond to the COVID-19 pandemic in Ontario, Canada.

Background: The COVID-19 pandemic is a significant public health emergency that impacts all sectors of healthcare. The negative health outcomes for the COVID-19 infection have been most severe in the frail elderly dwelling in Canadian long-term care (LTC) homes.

Methods: An online cross-sectional survey of Ontario LTC Clinicians working in LTC homes in Ontario Canada was conducted to provide the clinician perspective on the preparedness and engagement of the LTC sector during the COVID-19 pandemic.

Clustering of asymptomatic Plasmodium falciparum infection and the effectiveness of targeted malaria control measures.

Background: Because clustering of Plasmodium falciparum infection had been noted previously, the clustering of infection was examined at four field sites in West Africa: Dangassa and Dioro in Mali, Gambissara in The Gambia and Madina Fall in Senegal.

Methods: Clustering of infection was defined by the percent of persons with positive slides for asexual P. falciparum sleeping in a house which had been geopositioned.

Expanding Research Capacity in Sub-Saharan Africa Through Informatics, Bioinformatics, and Data Science Training Programs in Mali.

Bioinformatics and data science research have boundless potential across Africa due to its high levels of genetic diversity and disproportionate burden of infectious diseases, including malaria, tuberculosis, HIV and AIDS, Ebola virus disease, and Lassa fever. This work lays out an incremental approach for reaching underserved countries in bioinformatics and data science research through a progression of capacity building, training, and research efforts. Two global health informatics training programs sponsored by the Fogarty International Center (FIC) were carried out at the University of Sciences, Techniques and Technologies of Bamako, Mali (USTTB) between 1999 and 2011.

Development of a data collection and management system in West Africa: challenges and sustainability.

Background: Developing and sustaining a data collection and management system (DCMS) is difficult in malaria-endemic countries because of limitations in internet bandwidth, computer resources and numbers of trained personnel. The premise of this paper is that development of a DCMS in West Africa was a critically important outcome of the West African International Centers of Excellence for Malaria Research. The purposes of this paper are to make that information available to other investigators and to encourage the linkage of DCMSs to international research and Ministry of Health data systems and repositories.

AQ-13, an investigational antimalarial, versus artemether plus lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria: a randomised, phase 2, non-inferiority clinical trial.

Background: Chloroquine was used for malaria treatment until resistant Plasmodium falciparum was identified. Because 4-aminoquinolines with modified side chains, such as AQ-13, are active against resistant parasites, we compared AQ-13 against artemether plus lumefantrine for treatment of uncomplicated P falciparum malaria.

Methods: We did a randomised, non-inferiority trial.

Parental Influences on Heavy Episodic Drinking Development in the Transition to Early Adulthood.

Purpose: The purpose of this study was to examine how parental relationship quality (communication frequency, time spent together, and closeness) during early adulthood is related to heavy episodic drinking (HED) during this developmental period and whether effects vary according to age, youth sex, or parent sex.

Methods: National data from the Panel Study of Income Dynamics-Transition to Adulthood Study were analyzed. Youth participated in up to four interviews (2005, 2007, 2009, and 2011; n = 1,320-1,489) between ages 18-25 years.

Perceived Discrimination and Heavy Episodic Drinking Among African-American Youth: Differences by Age and Reason for Discrimination.

Purpose: The purpose of this study was to examine whether associations between perceived discrimination and heavy episodic drinking (HED) vary by age and by discrimination type (e.g., racial, age, physical appearance) among African-American youth.

Improving malaria control in West Africa: interruption of transmission as a paradigm shift.

With the paradigm shift from the reduction of morbidity and mortality to the interruption of transmission, the focus of malaria control broadens from symptomatic infections in children ≤5 years of age to include asymptomatic infections in older children and adults. In addition, as control efforts intensify and the number of interventions increases, there will be decreases in prevalence, incidence and transmission with additional decreases in morbidity and mortality. Expected secondary consequences of these changes include upward shifts in the peak ages for infection (parasitemia) and disease, increases in the ages for acquisition of antiparasite humoral and cellular immune responses and increases in false-negative blood smears and rapid diagnostic tests.

Race-specific trends in infant mortality: contributions of birth-weight distribution and birth-weight-specific mortality, Louisiana 1991-2002.

Objectives: To assess the race-specific trends in infant mortality rate (IMR) in Louisiana and identify changes in the birth weight distribution (BWD) and birth weight specific mortality (BWSM) and their effect on the overall infant mortality rate.

Methods: We used the state of Louisiana's period-linked birth/infant death file, 1991-2002. The difference in race-specific mortality between our study population and the reference population was partitioned into two components, BWD and BWSM, using the method developed by Kitagawa.

Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteers.

Objectives: To determine: (1) the pharmacokinetics and safety of an investigational aminoquinoline active against multidrug-resistant malaria parasites (AQ-13), including its effects on the QT interval, and (2) whether it has pharmacokinetic and safety profiles similar to chloroquine (CQ) in humans.

Design: Phase I double-blind, randomized controlled trials to compare AQ-13 and CQ in healthy volunteers. Randomizations were performed at each step after completion of the previous dose.

Hierarchical modeling and other spatial analyses in prostate cancer incidence data.

Background: State central cancer registries are often asked to respond to questions about the spatial distribution of cancer cases. Spatial analysis methods and technology are evolving rapidly, and can be a considerable challenge to registries that do not have staff with training in this area. The purpose of this article is to describe a general methodological approach that potentially might be a starting point for many cancer registry spatial analyses at the county level.

Statistical methods for linking health, exposure, and hazards.

The Environmental Public Health Tracking Network (EPHTN) proposes to link environmental hazards and exposures to health outcomes. Statistical methods used in case-control and cohort studies to link health outcomes to individual exposure estimates are well developed. However, reliable exposure estimates for many contaminants are not available at the individual level.

Post-traumatic stress disorder in children following road traffic accidents: a comparison of those with and without mild traumatic brain injury.

Background: It is now recognized that post-traumatic stress disorder (PTSD) can occur following road traffic accidents, but controversy exists about the possibility of PTSD in people sustaining traumatic brain injury (TBI). The present investigation examined the frequency, course and comorbidity of PTSD in children with and without mild TBI after traffic accidents.

Method: Interviews were conducted with 43 children and their parents 6 weeks after a traffic accident,assessing PTSD and associated symptomatology.

Technology meets healthcare: distance learning and telehealth.

In a time of increasing demands on physician productivity, computer and communication technologies allow health professionals to experiment with many applications that may provide opportunities to meet clinical demands while still participating in educational and research activities. "Telehealth" is a comprehensive term for the support of long distance clinical healthcare, patient and professional health-related education, public health, and health administration. Educational opportunities are growing exponentially for those who cannot attend traditional courses because of limited time or geographic considerations.

Perioperative transfusion, postoperative infection, and recurrence of head and neck cancer.

Background: Immunologic effects of perioperative transfusion and postoperative infection have been purported to influence cancer recurrence rates.

Methods: Records of all head and neck cancer patients having surgical extirpation of the primary tumor and/or regional nodes at our institution over a 5-year period were reviewed. Time to recurrence was the outcome measure.

Effect of strain and age of the broiler breeder female on incubation time and chick weight.

Two experiments were conducted to evaluate effects of strain [five in Experiment (Exp.) 1 and six in Exp. 2)] and age (29, 47, and 57 wk in Exp.

Relaxin: an ovarian hormone in an avian species (Gallus domesticus).

The objective of this study was to characterize the biochemical, immunological, and biological activity of avian relaxin and to immunolocalize relaxin-like peptides in the ovary of the hen (Gallus domesticus). A relaxin-like peptide was partially purified from ovaries of actively laying hens by size-exclusion chromatography and further purified by ion-exchange chromatography on CM-cellulose. Those fractions containing relaxin immunoreactivity were identified with the use of a homologous porcine relaxin radioimmunoassay on selected column effluent and pooled, and a sample was subjected to SDS-gel electrophoresis.

Collaborative care for obstetric patients at low and high risk: an evolving model.

Objective: In this article we describe a program that evolved from collaborative care given to a low-risk population into collaborative care that included patients at high risk.

Study Design: The study population comprised women attending a prenatal program in an urban, underserved neighborhood. Clinic records were reviewed for number of patient enrollments and total patient visits, as well as providers utilized.

Does cigarette smoking paradoxically increase survival in idiopathic dilated cardiomyopathy?. The Washington, D.C., Dilated Cardiomyopathy Study.

Recent studies have suggested that patients with idiopathic dilated cardiomyopathy (IDCM) who smoke have an improved prognosis as compared with nonsmokers. We examined this paradoxical finding using data from a population-based study in Washington, D.C.

Low temperature effects on embryonic development and hatch time.

A series of experiments was conducted to estimate phenotypic correlations between incubation characteristics, and to evaluate the effects of cold stress and genotype during incubation on chick weight, egg weight loss, hatching time, and embryonic mortality. Eggs were cooled at 18 or 24 C, for 12, 24, 36, 48, or 72 h beginning on Day 8, 12, 14, 16, or 18 of incubation. Other eggs were cooled intermittently for 6 h every 48 h or 12 h every 96 h.

Evaluation of alternate methods of rapid assessment of endemicity of Onchocerca volvulus in communities in southern Cameroon.

Potential diagnostic indicators of onchocerciasis (subcutaneous nodules, depigmentation or leopard skin, microfilaruria, diethylcarbamazine patch test positivity, excoriations, and pruritus) were evaluated in a rain forest region of southern Cameroon for usefulness in rapid assessment of onchocerciasis endemicity in communities. Thirty-two study villages were selected, representing high, intermediate, and low prevalence levels, and 846 adult male residents of these communities 20 or more years of age were examined according to a defined protocol. Skin snips (from each iliac crest) served as the reference standard.

Respiratory illness, beta-agonists, and risk of idiopathic dilated cardiomyopathy. The Washington, DC, Dilated Cardiomyopathy Study.

An epidemiologic study was carried out to examine the possible role of beta-agonists and other respiratory medications in the development of idiopathic dilated cardiomyopathy. Associations with respiratory medications, bronchial asthma, emphysema, and chronic bronchitis were examined by comparing newly diagnosed cases (n = 129) ascertained from five Washington, DC, area hospitals for the period 1990-1992 with neighborhood controls (n = 258) identified by using a random digit dialing technique. The cases and controls were matched on sex and 5-year age intervals and were compared in the analysis using conditional logistic regression methods.