Results and complications after 2-level axial lumbar interbody fusion with a minimum 2-year follow-up.

Object: Axial lumbar interbody fusion (AxiaLIF) is a minimally invasive presacral surgical technique that damages neither the anulus fibrosus nor the anterior or posterior longitudinal ligaments. The technique was initially designed and used for L5-S1 interbody fusions and recently was extended to 2-level fusions (L4-5 and L5-S1). Until now, only biomechanical and radiological studies have discussed the feasibility of this new indication, and no clinical study has been published.

Guided wave expansion in warped curvelet frames.

Lamb wave testing for structural health monitoring (SHM) often relies on analysis of wavefields recorded through scanning laser Doppler vibrometers (SLDVs) or ultrasonic scanners. Damage detection and characterization with these techniques requires isolation of defect-induced reflections in the wavefield from the injected wave packet and from scattering events associated with structural features such as boundaries, rivets, joints, etc. This is a challenging task when dealing with complex structures and multimodal, dispersive propagation regimes, whereby various wave contributions in both the time/space and the frequency/wavenumber domain overlap.

Lateral interbody fusion for treatment of discogenic low back pain: minimally invasive surgical techniques.

Low back pain is one of the most common ailments in the general population, which tends to increase in severity along with aging. While few patients have severe enough symptoms or underlying pathology to warrant surgical intervention, in those select cases treatment choices remain controversial and reimbursement is a substancial barrier to surgery. The object of this study was to examine outcomes of discogenic back pain without radiculopathy following minimally-invasive lateral interbody fusion.

Stand-alone lateral interbody fusion for the treatment of low-grade degenerative spondylolisthesis.

The purpose of this paper was to investigate the stand-alone lateral interbody fusion as a minimally invasive option for the treatment of low-grade degenerative spondylolisthesis with a minimum 24-month followup. Prospective nonrandomized observational single-center study. 52 consecutive patients (67.

The importance of the anterior longitudinal ligament in lumbar disc arthroplasty: 36-Month follow-up experience in extreme lateral total disc replacement.

Background: Current total disc replacement (TDR) for lumbar spine requires an anterior approach for implantation but presents inherent limitations, including risks to the abdominal structures, as well as resection of the anterior longitudinal ligament. By approaching the spine laterally, it is possible to preserve the stabilizing ligaments, which are a natural restraint to excessive rotations and translations, and thereby help to minimize facet stresses. This less invasive approach also offers a biomechanical advantage of placement of the device over the ring apophysis bilaterally; importantly, it also offers a greater opportunity for safer revision surgery, if necessary, by avoiding scarring of the anterior vasculature.

The relationship between smile attractiveness and esthetic parameters of patients with lateral agenesis treated with tooth recontouring or implants.

Background: The purpose of this study was to associate smile esthetic judgment with dentofacial attributes of patients with unilateral and bilateral agenesis of maxillary lateral incisors treated with recontouring of canines or implants and patients with no agenesis (control).

Material And Methods: Forty-six participants were divided into two groups: those treated with recontouring (N = 26) and those treated with implants (N = 20). The participants in the control group (N = 22) were selected among dentistry students at the State University of Maringá, Brazil.

Minimally invasive lateral approach for symptomatic thoracic disc herniation: initial multicenter clinical experience.

Object: Symptomatic herniated thoracic discs remain a surgical challenge and historically have been associated with significant complications. While neurological outcomes have improved with the abandonment of decompressive laminectomy, the attempt to minimize surgical complications and associated morbidities continues through less invasive approaches. Many of these techniques, such as thoracoscopy, have not been widely adopted due to technical difficulties.

Parathyroid gland anatomical distribution and relation to anthropometric and demographic parameters: a cadaveric study.

Parathyroid glands play an important role in controlling calcium levels, which influence muscular contraction and neurotransmission. The number of variants, localization and ectopic positions make these glands tricky during surgical exploration. Detailed anatomical knowledge of these glands is fundamental to avoid postsurgical hypoparathyroidism, such as failures during thyroidectomy and parathyroid procedures.

Chronic cold stress in mice induces a regulatory phenotype in macrophages: correlation with increased 11β-hydroxysteroid dehydrogenase expression.

Susceptibility to infections, autoimmune disorders and tumor progression is strongly influenced by the activity of the endocrine and nervous systems in response to a stressful stimulus. When the adaptive system is switched on and off efficiently, the body is able to recover from the stress imposed. However, when the system is activated repeatedly or the activity is sustained, as during chronic or excessive stress, an allostatic load is generated, which can lead to disease over long periods of time.

Double-channel, frequency-steered acoustic transducer with 2-D imaging capabilities.

A frequency-steerable acoustic transducer (FSAT) is employed for imaging of damage in plates through guided wave inspection. The FSAT is a shaped array with a spatial distribution that defines a spiral in wavenumber space. Its resulting frequency-dependent directional properties allow beam steering to be performed by a single two-channel device, which can be used for the imaging of a two-dimensional half-plane.

Effect of academic psychological stress in post-graduate students: the modulatory role of cortisol on superoxide release by neutrophils.

Experimental and clinical evidence shows that neutrophils play an important role in the mechanism of tissue injury in immune complex diseases through the generation of reactive oxygen species. In this study, we examined the influence of academic psychological stress in post-graduate students on the capacity of their blood neutrophils to release superoxide when stimulated by immune complexes bound to nonphagocytosable surfaces and investigated the modulatory effect of cortisol on this immune function. The tests were performed on the day before the final examination.

A radiographic assessment of the ability of the extreme lateral interbody fusion procedure to indirectly decompress the neural elements.

Study Design: Prospective nonrandomized clinical study on the decompressive effect of the extreme lateral interbody fusion (XLIF) procedure.

Objective: This study evaluates the results of interbody distraction from a lateral retroperitoneal approach for the treatment of lumbar degenerative conditions inclusive of central and/or lateral stenosis.

Summary Of Background Data: Traditional treatment for symptomatic lumbar stenosis has been by direct posterior decompression (i.

Lumbar total disc replacement from an extreme lateral approach: clinical experience with a minimum of 2 years' follow-up.

Object: current lumbar total disc replacement (TDR) devices require an anterior approach for implantation. This approach has inherent limitations, including risks to abdominal structures and the need for resection of the anterior longitudinal ligament (ALL). Placement of a TDR device from a true lateral (extreme lateral interbody fusion [XLIF]) approach is thought to offer a less invasive option to access the disc space, preserving the stabilizing ligaments and avoiding scarring of anterior vasculature.

Warped basis pursuit for damage detection using lamb waves.

This paper presents a novel time-frequency procedure based on the warped frequency transform (WFT) to process multi-mode and dispersive Lamb waves for structural health monitoring (SHM) applications. The proposed signal processing technique is applied to time waveforms recorded at an array of scan points after waveguide excitation. The WFT is combined with a basis pursuit algorithm to extract the distance traveled by the ultrasonic waves even in the case of multi-modal dispersive propagation associated with broadband excitation of the waveguide.

Gene therapy with interleukin-10 receptor and interleukin-12 induces a protective interferon-γ-dependent response against B16F10-Nex2 melanoma.

Antitumor immune responses are associated with proinflammatory cytokines, whereas tumor-developing animals generally have increased the production of immunosuppressive cytokines. Here, we show that splenocytes from C57Bl/6 mice resistant to low doses of B16F10-Nex2 melanoma cells produced twofold or higher interferon-γ (IFN-γ)/interleukin-10 (IL-10) ratios, whereas cells from tumor-bearing animals produced predominantly IL-10. IL-10-knockout (IL-10KO) mice were significantly more resistant to B16F10-Nex2 development, producing increased amounts of IL-12 and IFN-γ.

Dexmedetomidine sedation for awake tracheotomy: case report and literature review.

The safe administration of conscious sedation in a patient with a critical airway who underwent awake tracheotomy using dexmedetomidine, a selective alpha(2)-agonist with sympatholytic, anxiolytic, analgesic, and sedative properties, is presented. Unlike other commonly used sedative agents, dexmedetomidine provided adequate sedation with minimal respiratory depression.

Ultrasonic guided-waves characterization with warped frequency transforms.

Guided wave (GW) dispersion curves can be extracted from a time-transient measurement by means of timefrequency representations (TFRs). Unfortunately, any TFR is subject to the time-frequency uncertainty principle. This, in general, limits the capability of TFRs to characterize closely spaced guided modes over a wide frequency range.

Predictive deconvolution and hybrid feature selection for computer-aided detection of prostate cancer.

Computer-aided detection (CAD) schemes are decision making support tools, useful to overcome limitations of problematic clinical procedures. Trans-rectal ultrasound image based CAD would be extremely important to support prostate cancer diagnosis. An effective approach to realize a CAD scheme for this purpose is described in this work, employing a multi-feature kernel classification model based on generalized discriminant analysis.

A reduced complexity estimation algorithm for ultrasound images de-blurring.

In this paper we propose a deconvolution technique for ultrasound images based on a Maximum Likelihood (ML) estimation procedure. In our approach the ultrasonic radio-frequency (RF) signal is considered as a sequence affected by Intersymbol Interference (ISI) and AWG noise. In order to reduce the computational cost, the estimation is performed with a reduced-state Viterbi algorithm.

Systems and Sensors for Debris-flow Monitoring and Warning.

Debris flows are a type of mass movement that occurs in mountain torrents. They consist of a high concentration of solid material in water that flows as a wave with a steep front. Debris flows can be considered a phenomenon intermediate between landslides and water floods.

Procedures for the documentation of historical debris flows: application to the Chieppena Torrent (Italian alps).

The reconstruction of triggering conditions, geomorphic effects, and damage produced by historical floods and debris flows significantly contributes to hazard assessment, allowing improved risk mitigation measures to be defined. Methods for the analysis of historical floods and debris flows vary greatly according to the type and quality of available data, which in turn are influenced by the time the events occurred. For floods and debris flows occurring in the Alps a few decades ago (between about 1950 and 1980), the documentation is usually better than for previous periods but, unlike events of most recent years, quantitative data are usually scanty and the description of the events does not aim to identify processes according to current terminology and classifications.

Evaluation of continuous aspiration of subglottic secretion in an in vivo study.

Objective: Continuous aspiration of subglottic secretions (CASS) is believed to lower the incidence of ventilator-associated pneumonia. Animal studies to establish safety and efficacy of CASS have not been conducted.

Design: Prospective randomized animal study.

Endotracheal tubes coated with antiseptics decrease bacterial colonization of the ventilator circuits, lungs, and endotracheal tube.

Background: Formation of a bacterial biofilm within the endotracheal tube (ETT) after tracheal intubation is rapid and represents a ready source of lung bacterial colonization. The authors investigated bacterial colonization of the ventilator circuit, the ETT, and the lungs when the ETT was coated with silver-sulfadiazine and chlorhexidine in polyurethane, using no bacterial/viral filter attached to the ETT.

Methods: Sixteen sheep were randomized into two groups.