Frontal and cerebellar contributions to pitch and rhythm processing: a TMS study.

Music represents a salient stimulus for the brain with two key features: pitch and rhythm. Few data are available on cognitive analysis of music listening in musically naïve healthy participants. Beyond auditory cortices, neuroimaging data showed the involvement of prefrontal cortex in pitch and of cerebellum in rhythm.

Right-deviating prismatic adaptation reduces obsessions in a community sample.

Background And Aims: Patients with obsessive-compulsive (OC) disorder are impaired in disengaging attention from negative valence stimuli and show an attentional bias toward the right space. This pattern in OC disorder is similar to the impaired disengagement of attention from stimuli in the ipsilesional space as a consequence of a right-hemispheric cerebral lesion in patients with neglect, suggesting a right hemispheric dysfunction in patients with OC disorder. The attentional impairment in patients with neglect is reduced by a visuomotor procedure, such as prismatic adaptation (PA) with right-deviating lenses.

Neglect in temporal domain: Amelioration following a prismatic adaptation treatment and implications in everyday life. A single case study.

As in line bisection, in time bisection, neglect patients fail to process the first/left part of time representation (Mental-Time-Line-MTL) resulting in a rightward shift of the interval midpoint. A leftward shift of spatial attention after one session of prismatic-adaptation (PA) reduces this deficit. The impact on daily life of time deficit is little investigated in neglect.

Therapeutic Drug Monitoring of Second- and Third-Generation Antiepileptic Drugs.

Context.—: Therapeutic drug monitoring has traditionally been widely used for first-generation antiepileptic drugs (AEDs) such as carbamazepine and phenytoin. The last 2 decades have seen the introduction of second- and third-generation AEDs (eg, lamotrigine, levetiracetam, and topiramate) into clinical practice.

Ethanol Biomarker Testing and Challenges.

Context.—: Clinical and forensic testing for ethanol biomarkers, including ethyl glucuronide (EtG) and ethyl sulfate (EtS), is used to discern alcohol use from abstinence. These markers can be key in major decisions, including transplant eligibility or retaining licensure after alcohol misuse.

Spatial attention and representation of time intervals in childhood.

Spatial attention and spatial representation of time are strictly linked in the human brain. In young adults, a leftward shift of spatial attention by prismatic adaptation (PA), is associated with an underestimation whereas a rightward shift is associated with an overestimation of time both for visual and auditory stimuli. These results suggest a supra-modal representation of time left-to-right oriented that is modulated by a bilateral attentional shift.

Early stages in the self-organization of Si nanopatterns induced by ion bombardment.

We reveal early stages of self-organization of nanopatterns created by 2 keV Cs ion-beam irradiation of a Si surface coated with Au and a Ti adhesion layer. After ion-beam etching of the metallic layers, at normal incidence, we first observe distinct transient stages: (I) a dewetting-like pattern of grooves in the Si amorphized layer, sparsely populated with holes, followed by (II) the coexistence of rounded mounds and faceted holes distributed on a flat surface, the latter being an indication of the decisive role played by the crystalline/amorphous interface. Subsequently, the system evolves to stage III, a nanopattern of densely packed nanodots convoluted with a long-wavelength surface corrugation.

Interpretation and Utility of Drug of Abuse Screening Immunoassays: Insights From Laboratory Drug Testing Proficiency Surveys.

Context.—: Urine drug testing is frequently ordered by health care providers. Immunoassays are widely used for drug testing, yet have potential limitations, including variable cross-reactivity.

Urine and oral fluid drug testing in support of pain management.

In recent years, the abuse of opioid drugs has resulted in greater prevalence of addiction, overdose, and deaths attributable to opioid abuse. The epidemic of opioid abuse has prompted professional and government agencies to issue practice guidelines for prescribing opioids to manage chronic pain. An important tool available to providers is the drug test for use in the initial assessment of patients for possible opioid therapy, subsequent monitoring of compliance, and documentation of suspected aberrant drug behaviors.

Innate and Cultural Spatial Time: A Developmental Perspective.

We reviewed literature to understand when a spatial map for time is available in the brain. We carefully defined the concepts of metrical map of time and of conceptual representation of time as the mental time line (MTL) in order to formulate our position. It is that both metrical map and conceptual representation of time are spatial in nature.

Keeping secrets from friends: Exploring the effects of friendship quality, loneliness and self-esteem on secrecy.

The tendency to keep secrets in adolescents has been studied in particular in their relationships with their parents and associated with psychosocial disadvantages. The current study focused on peer relationships and investigated the effects of friendship quality, loneliness in a multidimensional perspective, and self-esteem on secrecy from friends. Italian adolescents (N = 457; 47% male; 100% white) aged between 13 and 19 years (M = 16.

See, Test & Treat: A 5-Year Experience of Pathologists Driving Cervical and Breast Cancer Screening to Underserved and Underinsured Populations.

Context: - See, Test & Treat is a pathologist-driven program to provide cervical and breast cancer screening to underserved and underinsured patient populations. This program is largely funded by the CAP Foundation (College of American Pathologists, Northfield, Illinois) and is a collaborative effort among several medical specialties united to address gaps in the current health care system.

Objective: - To provide an outline for administering a See, Test & Treat program, using an academic medical center as a model for providing care and collating the results of 5 years of data on the See, Test & Treat program's findings.

Exploring the Link among State of Mind Concerning Childhood Attachment, Attachment in Close Relationships, Parental Bonding, and Psychopathological Symptoms in Substance Users.

Background: In the present study, we have explored the link among styles of attachment and psychopathology in drug users. We know that insecure attachment predisposes the individuals the development of drug-addiction and psychopathological symptoms. However, we do not know which attachment is more frequent in drug users and which is related to particular psychopathological symptoms.

Alternative uses of a megavolt tandem accelerator for few-keV studies with ion-source SIMS monitoring.

We increase the versatility of a tandem electrostatic accelerator by implementing simple modifications to the standard operation procedure. While keeping its ability to deliver MeV ion beams, we show that the experimental setup can (i) provide good quality ion beams in the few-keV energy range and (ii) be used to study ion-beam surface modification with simultaneous secondary ion mass spectrometry. This latter task is accomplished without using any chamber connected to the accelerator exit.

Frontiers of robotic endoscopic capsules: a review.

Digestive diseases are a major burden for society and healthcare systems, and with an aging population, the importance of their effective management will become critical. Healthcare systems worldwide already struggle to insure quality and affordability of healthcare delivery and this will be a significant challenge in the midterm future. Wireless capsule endoscopy (WCE), introduced in 2000 by Given Imaging Ltd.

The Pathologist Workforce in the United States: II. An Interactive Modeling Tool for Analyzing Future Qualitative and Quantitative Staffing Demands for Services.

Context: Pathologists are physicians who make diagnoses based on interpretation of tissue and cellular specimens (surgical/cytopathology, molecular/genomic pathology, autopsy), provide medical leadership and consultation for laboratory medicine, and are integral members of their institutions' interdisciplinary patient care teams.

Objective: To develop a dynamic modeling tool to examine how individual factors and practice variables can forecast demand for pathologist services.

Design: Build and test a computer-based software model populated with data from surveys and best estimates about current and new pathologist efforts.

The opioid abuse and misuse epidemic: implications for pharmacists in hospitals and health systems.

Purpose: The current epidemic of prescription opioid abuse and misuse in the United States is discussed, with an emphasis on the pharmacist's role in ensuring safe and effective opioid use.

Summary: U.S.

Exploring the reciprocal modulation of time and space in dancers and non-dancers.

We explored whether time and space representations modulate each other in subjects that are trained to integrate time and space dimensions, i.e., professional dancers.

Prismatic adaptation as a novel tool to directionally modulate motor cortex excitability: evidence from paired-pulse TMS.

Background: The prismatic adaptation (PA) is a visuo-motor procedure that has captured the attention of neuroscientists in the last decades, hence it seems to affect high-order cognition. However, the basic neural processes related to PA and its effects on cortical plasticity are not clear yet.

Objective/hypothesis: The aim of the present study is to explore whether PA induces a direct effect on the motor cortices (M1) excitability.