Aurora kinase inhibitors: a new class of targeted drugs in cancer.

Aurora kinases (A, B, and C) are essential for spindle assembly, centrosome maturation, chromosomal segregation, and cytokinesis. Aurora kinases A and B are overexpressed in many cancers, including non-small-cell lung cancer and mesothelioma. Small-molecule inhibitors selective for aurora kinases have shown promising activity in preclinical tumor models.

Measurement of the tt production cross section in pp collisions at square root of s = 1.96 TeV.

We present a measurement of the top quark pair production cross section in pp collisions at square root of s = 1.96 TeV using 318 pb(-1) of data collected with the Collider Detector at Fermilab. We select tt[over ] decays into the final states enu+jets and mu nu+ jets, in which at least one b quark from the t-quark decays is identified using a secondary vertex-finding algorithm.

Search for a neutral Higgs boson decaying to a W boson pair in pp collisions at square root of s = 1.96 TeV.

We present the results of a search for standard model Higgs boson production with decay to WW*, identified through the leptonic final states e+ e- nu nu,+/-mu -/+nu nu and mu+ mu- nu nu. This search uses 360 pb -1 of data collected from pp collisions at square root of s =1.96 TeV by the upgraded Collider Detector at Fermilab (CDF II).

Measurement of the Bs0-Bs0 oscillation frequency.

We present the first precise measurement of the Bs0-Bs0 oscillation frequency Deltams. We use 1 fb-1 of data from pp collisions at sqrts=1.96 TeV collected with the CDF II detector at the Fermilab Tevatron.

Search for new physics in lepton+photon+X events with 305 pb(-1) of pp collisions at [square root of s] = 1.96 TeV.

We present results of a search for anomalous production of events containing a charged lepton (l, either e or mu) and a photon (gamma), both with high transverse momentum, accompanied by additional signatures X, including missing transverse energy (ET) and additional leptons and photons. We use the same selection criteria as in a previous CDF search but with a substantially larger data set, 305 pb(-1), a pp collision energy of 1.96 TeV, and the CDF II detector.

Measurement of the Bc+ meson lifetime using the decay mode Bc+ --> J/Psie+nue.

We present a measurement of the Bc+ meson lifetime in the decay mode Bc+ --> J/Psie+nue using the Collider Detector at Fermilab II detector at the Fermilab Tevatron Collider. From a sample of about of 360 pb(-1) of pp collisions at square root of s = 1.96 TeV, we reconstruct J/Psie+ pairs with invariant mass in the kinematically allowed range 4< M(J/Psie) < 6 GeV/c2.

Observation of B(0)(s)-->Psi(2S)Phi and measurement of the ratio of branching fractions Beta(B(0)(s)-->Psi(2S)Phi)/Beta(B(0)(s)-->J/PsiPhi).

We report the first observation of B(0)(s)-->Psi(2S)Phi decay in p(p_) collisions at square root of 8=1.96 TeV using 360 pb(-1) of data collected by the CDF II detector at the Fermilab Tevatron. We observe 20.

Search for high-mass resonances decaying to emu in pp collisions at square root = 1.69 TeV.

We describe a general search for resonances decaying to a neutral emu final state in pp collisions at a center-of-mass energy of 1.96 TeV. Using a data sample representing 344 pb(-1) of integrated luminosity recorded by the Collider Detector at Fermilab II experiment, we compare standard model predictions with the number of observed events for invariant masses between 50 and 800 GeV/c2.

Search for Z' --> e+ e- using dielectron mass and angular distribution.

We search for Z' bosons in dielectron events produced in pp collisions at square root of s = 1.96 TeV, using 0.45 fb(-1) of data accumulated with the Collider Detector at Fermilab II detector at the Fermilab Tevatron.

Measurement of the tt production cross section in pp collisions at square root s = 1.96 TeV using missing E(T) + jets events with secondary vertex b tagging.

We present a measurement of the tt production cross section in pp collisions at square root s = 1.96 TeV which uses events with an inclusive signature of significant missing transverse energy and jets. This is the first measurement which makes no explicit lepton identification requirements, so that sensitivity to W --> tau nu decays is maintained.

Direct search for Dirac magnetic monopoles in pp collisions at square root s = 1.96 TeV.

We search for pair-produced Dirac magnetic monopoles in 35.7 pb(-1) of proton-antiproton collisions at square root s = 1.96 TeV with the Collider Detector at Fermilab (CDF).

Measurement of the ratios of branching fractions and.

We report an observation of the decay B(O)(S) --> D(-)(s)pi(+) in pp collisions at radical S = 1.96 TeV using 115 pb(-1) of data collected by the CDF II detector at the Fermilab Tevatron. We observe 83 +/- 11(stat) B(O)(s) --> D(-)(s)pi(+) candidates, representing a large increase in statistics over previous measurements and the first observation of this decay at a pp collider.

Pharmacodynamic separation of epidermal growth factor receptor tyrosine kinase inhibitors and chemotherapy in non-small-cell lung cancer.

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) given concurrently with chemotherapy do not improve patient outcomes compared with chemotherapy alone in advanced-stage non-small-cell lung cancer (NSCLC). One potential explanation for this lack of benefit is a negative interaction or antagonism between chemotherapy and EGFR TKIs when delivered concomitantly. Support for this line of reasoning is provided by preclinical data demonstrating that EGFR TKIs induce primarily a cytostatic effect resulting from a G1 cell cycle arrest in cell lines with wild-type EGFR, reducing cell cycle phase-dependent activity of chemotherapy, whereas they induce apoptotic cell death in tumors with EGFR-activating mutations.

Mating-responsive genes in reproductive tissues of female Drosophila melanogaster.

Male-derived accessory gland proteins that are transferred to females during mating have profound effects on female reproductive physiology including increased ovulation, mating inhibition, and effects on sperm utilization and storage. The extreme rates of evolution seen in accessory gland proteins may be driven by sperm competition and sexual conflict, processes that may ultimately drive complex interactions between female- and male-derived molecules and sperm. However, little is known of how gene expression in female reproductive tissues changes in response to the presence of male molecules and sperm.

Search for scalar bottom quarks from gluino decays in collisions at.

We searched for scalar bottom quarks 156 pb(-1) of pp collisions at radicalS = 1.96 recorded by the Collider Detector at Fermilab II experiment at the Tevatron. Scalar bottom quarks can be produced from gluino decays in -parity conserving models of supersymmetry when the mass of the gluino exceeds that of the scalar bottom quark.

Top-quark mass measurement from dilepton events at CDF II.

We report a measurement of the top-quark mass using events collected by the CDF II detector from pp collisions at square root of s = 1.96 TeV at the Fermilab Tevatron. We calculate a likelihood function for the top-quark mass in events that are consistent with tt --> bl(-)nu(l)bl'+ nu'(l) decays.

Exploring the molecular basis for mechanosensation, signal transduction, and cytoskeletal remodeling.

Living cells respond to mechanical stimulation in a variety of ways that affect nearly every aspect of their function. Such responses can range from changes in cell morphology to activation of signaling cascades and changes in cell phenotype. Although the biochemical signaling pathways activated by mechanical stimulus have been extensively studied, little is known of the basic mechanisms by which mechanical force is transduced into a biochemical signal, or how the cell changes its behavior or properties in response to external or internal stresses.

Evidence for the exclusive decay B(c)+- --> J/psi pi+- and measurement of the mass of the B(c)+- meson.

We report the first evidence for a fully reconstructed decay mode of the B(c)+- meson in the channel B(c)+- --> J/psi pi+-, with J/psi --> mu+ mu-. The analysis is based on an integrated luminosity of 360 pb(-1) in pp collisions at 1.96 TeV center of mass energy collected by the Collider Detector at Fermilab.

Search for Higgs bosons decaying to bb and produced in association with W bosons in pp collisions at square root of s = 1.96 TeV.

We present a search for Higgs bosons decaying into bb and produced in association with W bosons in pp collisions at square root of s = 1.96 TeV. This search uses 320 pb(-1) of the data set accumulated by the upgraded Collider Detector at Fermilab.

Measurement of the inclusive jet cross section using the kT algorithm in pp collisions at (square root s)=1.96 TeV.

We report on a measurement of the inclusive jet production cross section as a function of the jet transverse momentum in pp collisions at (square root s)=1.96 TeV using data collected with the upgraded Collider Detector at Fermilab in run II, corresponding to an integrated luminosity of 385 pb-1. The measurement is carried out for jets with rapidity 0.

Measurement of the dipion mass spectrum in decays.

We measure the dipion mass spectrum in X(3872)--> J/psipi(+) pi(-) decays using 360 pb(-1) of pp collisions at square root s= 1.96 TeV collected with the CDF II detector. The spectrum is fit with predictions for odd C-parity ((3)S(1), (1)P(1), and (3)D(J)) charmonia decaying to J/psipi(+) pi(-), as well as even C-parity states in which the pions are from rho(0) decay.

Search for charged Higgs bosons from top quark decays in pp collisions at square root s=1.96 TeV.

We report the results of a search for a charged Higgs boson in the decays of top quarks produced in pp collisions at a center-of-mass energy of 1.96 TeV. We use a data sample corresponding to an integrated luminosity of 193 pb-1 collected by the upgraded Collider Detector at Fermilab.

Precision top-quark mass measurement in the lepton+jets topology in p p collisions at square root s=1.96 TeV.

We report two measurements of the top-quark mass M(top) using the CDF II detector at the Fermilab Tevatron in a 318 pb(-1) data sample of tt events in the lepton+jets final state. One method uses an event-based likelihood technique resulting in M(top) = 173.2(-2.

Search for neutral Higgs bosons of the minimal supersymmetric standard model decaying to tau pairs in pp collisions at square root of s = 1.96 TeV.

We present a search for neutral supersymmetric Higgs bosons decaying to tau pairs produced in pp collisions at square root of s = 1.96 TeV. The data, corresponding to 310 pb(-1) integrated luminosity, were collected with the Collider Detector at Fermilab in run II of the Tevatron.

Therapeutic strategies for combined-modality therapy of locally advanced non-small-cell lung cancer: rationale for consolidation docetaxel therapy.

Currently, there is no accepted standard of care for locally advanced and surgically unresectable non-small-cell lung cancer. Typically, treatment for patients with good performance status consists of a combination of chemotherapy and thoracic radiation therapy (RT), but the integration of these modalities and the respective dose schedules vary considerably. Herein, we review the rationale for a treatment paradigm employing consolidation docetaxel therapy after concurrent chemotherapy/RT and the results of recent clinical trials using this approach.