Validated LC-MS/MS Method for the Determination of Paxalisib on Mouse Dried Blood Spots: An Application to Pharmacokinetic Study in Mice.

Paxalisib is a dual PI3K/mTOR inhibitor, being used in advanced cancer treatment. In this research, we report a validated LC-MS/MS method for quantifying paxalisib from mouse dried blood spot (DBS). We validated the method in-line with the FDA guidelines.

Machine learning-based technique for gain prediction of mm-wave miniaturized 5G MIMO slotted antenna array with high isolation characteristics.

This study presents the design and analysis of a compact 28 GHz MIMO antenna for 5G wireless networks, incorporating simulations, measurements, and machine learning (ML) techniques to optimize its performance. With dimensions of 3.19 λ₀ × 3.

High-Density and Well-Aligned Hierarchical Structures of Colloids Assembled under Orthogonal Magnetic and Electric Fields.

Colloids can be used either as model systems for directed assembly or as the necessary building blocks for making functional materials. Previous work primarily focused on assembling colloids under a single external field, where controlling particle-particle interactions is limited. This work presents results under a combination of electric and magnetic fields.

Contagion comeback: unravelling the measles outbreak across the USA.

Measles, a highly contagious respiratory illness caused by the measles virus (MeV), poses significant global and national public health challenges despite advancements in vaccination efforts. Though measles was declared eliminated in the United States in 2000, recent years have seen a resurgence of cases, particularly in under-vaccinated communities. This resurgence is compounded by factors such as vaccine hesitancy, the impact of the COVID-19 pandemic on immunization rates, and international travel introducing new cases from endemic regions.

Development and optimization of dapagliflozin oral nano-bilosomes using response surface method: evaluation, evaluation.

In treating type 2 diabetes, avoiding glucose reabsorption (glucotoxicity) and managing hyperglycemia are also important. A metabolic condition known as diabetes (type-2) is characterized by high blood sugar levels in comparison to normal Bilosomes (BLs) containing Dapagliflozin (Dapa) were formulated, optimized, and tested for oral therapeutic efficacy in the current investigation. Used the Box Behnken design to optimize the Dapa-BLs, formulated via a thin-film hydration technique.

Machine learning-based novel-shaped THz MIMO antenna with a slotted ground plane for future 6G applications.

This study discusses the results of using a regression machine learning technique to improve the performance of 6G applications that use multiple-input multiple-output (MIMO) antennas operating at the terahertz (THz) frequency band. This research evaluates an antenna's performance using various methodologies, such as simulation and RLC equivalent circuit models. The suggested design has a broad bandwidth of 2.

Optimizing Pectin Yield From Burmese Grape () Peels Using Box-Behnken Design and Quality Evaluation.

Pectin, a polysaccharide, is widely used as a gelling and thickening agent in the food industry. This study undertook optimization of pectin extraction from the peels of Lour. (Burmese grape or lotkon), an abundantly grown wild fruit in Bangladesh.

Rice bran and rice bran oil production perspective in Bangladesh: a review.

Rice, a staple food in Bangladesh, produces substantial quantities of rice bran as a by-product, offering considerable potential for advancing agriculture. While rice bran holds value, traditional uses like poultry feed and landfilling remain prevalent despite growing interest in its broader applications. This article explores the current status, stabilization methods, oil extraction techniques, and opportunities and challenges associated with rice bran utilization in Bangladesh.

Complications due to HIV in patients undergoing total joint arthroplasty: A systematic review and meta-analysis.

Background: HIV infection in patients undergoing Total joint arthroplasty (TJA) results in adverse postoperative outcomes. However, there are uncertain data regarding the extent of involvement of HIV in TJA and the individual complications associated with it. Therefore, we planned to conduct a systematic review and meta-analysis to assess the risk of HIV in causing complications after TJA.

Efficacy and safety of Donidalorsen in Hereditary Angioedema with C1 inhibitor deficiency: a systematic review and a meta analysis.

Hereditary angioedema with C1 inhibitor deficiency (HAE-C1-INH) is a rare disorder characterized by recurrent, potentially life-threatening swelling in various parts of the body, including the limbs, face, and airways Current treatments focus primarily on symptomatic relief and the management of acute attacks, without targeting the underlying genetic cause or the dysregulated bradykinin production. Donidalorsen, a novel antisense oligonucleotide, addresses a key driver of HAE-C1-INH by targeting prekallikrein (PKK) to reduce bradykinin levels. This meta-analysis evaluates the efficacy and safety of Donidalorsen versus placebo, focusing on two dosing regimens: 4-week and 8-week intervals.

Social norms and maternal health information-seeking behavior among adolescent girls: A qualitative study in a slum of Bangladesh.

Adolescent girls of reproductive age who actively seek information on maternal health often tend to have better health-seeking behaviors and maternal health outcomes. Due to scant research on reproductive aged adolescent girls' maternal health information seeking behavior in slum, in connection with social norms, we aimed for this particular study. Adopting an explorative qualitative research approach, we collected data from purposively selected married and unmarried adolescent girls aged 15-19 of different occupation by implying 12 in-depth interviews (IDIs), 2 focus group discussions (FGDs) with the same categories employed for IDIs, and 2 key informant interviews (KIIs) with a traditional birth attendant and a drug seller.

Electrical Tunability of Quantum-Dot-in-Perovskite Solids.

The quantum-dot-in-perovskite matrix (DIM) is an emerging class of semiconductors for optoelectronics enabled by their complementary charge transport properties and stability improvements. However, a detailed understanding of the pure electrical properties in DIM is still in its early stage. Here, we developed PbS quantum dot-in-CsSnI matrix solids exhibiting improved electrical properties and enhanced stability.

Cardioprotective action of apocynin in isoproterenol-induced cardiac damage is mediated through Nrf-2/HO-1 signaling pathway.

This investigation evaluated the therapeutic benefit of apocynin in isoproterenol (ISO)-induced cardiac damage in rats. ISO-administered male Wistar rats were treated with apocynin for 2 weeks. Blood plasma and left ventricle of heart tissues were collected and analyzed for oxidative stress-related parameters such as malondialdehyde (MDA), advanced oxidation protein product (AOPP), and nitric oxide (NO).

A Comprehensive Case Report on Familial Multiple Lipomatosis.

Familial multiple lipomatosis (FML) is a rare autosomal dominant disorder characterized by the progressive development of encapsulated nodules predominantly on the trunk and extremities. Its genetic basis is linked to HMGA-2 gene over-expression. The condition is diagnosed via clinical history, ultrasound findings, and histological studies, and management mainly comprises surgical excision.

Sociodemographic and maternal health-related factors associated with mortality among children under three in Bangladesh: an analysis of data from Bangladesh Demographic and Health Survey 2017-18.

Background: Child mortality remains remarkably high in many low- and middle-income countries (LMICs), including Bangladesh. This study aimed to identify the sociodemographic and maternal health-related factors associated with under three (U3) child mortality in Bangladesh.

Methods: We extracted data of 5299 U3 children from Bangladesh Demographic and Health Survey (BDHS) 2017-18.

Immunogenicity and protective efficacy of an inactivated infectious bronchitis virus vaccine candidate from a local isolate of Bangladesh.

Objective: Infectious bronchitis (IB), a highly infectious acute viral disease, is a major burden to the chicken industry worldwide. The research aimed to develop an inactivated IB vaccine using local isolates and assess its immunogenicity compared to other commercial live IB vaccines.

Materials And Methods: An inactivated vaccine using a candidate IB virus (PP067159.

Construction of women's empowerment index for Bangladesh.

Introduction: This study is dedicated to refining and enhancing the measurement model of women's empowerment in Bangladesh. Women's empowerment, a crucial and multifaceted aspect of societal growth, is often hindered by gender disparities. This is particularly evident in societies like Bangladesh, where women face inequalities in education, economic opportunities, and decision-making power.

TPTC: topic-wise problems' trend clusters for smart agricultural insights extraction and forecasting of farmer's information demand.

To meet the challenges of increasing food production demand globally, extracting insights regarding the persistent agriculture-related problems on a nationwide scale is the need of the hour. Policymakers now have limited possibilities for acquiring a comprehensive knowledge of the difficulties that farmers face on a national level. In this direction, the presented work proposes a new artificial intelligence-based pipeline to gain insights at country level regarding the farmers' demand for assistance in India.

Environmental factors regulating the population dynamics and reproductive strategy of freshwater mussel in the Padma River, Bangladesh.

Freshwater mussel is an ecologically important species endemic to south-east Asia, which has been suffering from a dramatic decline in recent years. The present study investigated the population dynamics and reproductive strategy of in a changing climate of Bangladesh waters. Mussels were sampled monthly from January to December 2021 from the Padma River near the Rajshahi city of Bangladesh.

Design, synthesis, molecular docking, and dynamics studies of novel thiazole-Schiff base derivatives containing a fluorene moiety and the assessment of their antimicrobial and antioxidant activity.

In this study, a series of eighteen fluorene-containing substituted thiazole derivatives were synthesized and characterized spectral analyses. The proposed compounds were screened for their antimicrobial activity, and it was found that compound 2a displayed a significant zone of inhibition (20.3 ± 0.