Publications by authors named "MA H"
Article Synopsis
- * SHC SH2 domain-binding protein 1 (SHCBP1) was found to be overexpressed in ovarian cancer, promoting cell growth and contributing to resistance against cisplatin chemotherapy.
- * Silencing SHCBP1 enhanced the effectiveness of cisplatin treatment and inhibited tumor growth in laboratory settings, suggesting that targeting SHCBP1 could improve outcomes for ovarian cancer therapies.
Chronic active Epstein-Barr virus infection (CAEBV) is a progressive and life-threatening disease characterized by persistent or recurrent EBV activation. It has been reported that, γδ T cells, a type of cytotoxic lymphocyte, play a critical role in restricting EBV. However, the functional status of γδ T cells in pediatric CAEBV patients has not yet been described.
View Article and Find Full Text PDFThe cuticle is the first physical barrier covering the surface of tomatoes and plays an important role in multiple stress responses. But the molecular regulatory networks of cuticle formation are not fully understood. In this study, we found that SlMYB72 can interact with SlTAGL1 to regulate the formation of fruit cuticle in tomato.
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- Recent studies suggest that titanium exposure may negatively affect glucose metabolism, but its link to gestational diabetes mellitus (GDM) is not well-studied.
- A study involving 1,449 pregnant women in China found that higher levels of urinary titanium in early pregnancy were associated with a 30% increased risk of developing GDM.
- The research identified specific metabolites (choline, creatine, and L-alanine) involved in amino acid metabolism that may help explain how titanium exposure influences GDM risk.
Article Synopsis
- Drought stress significantly impacts forage yields, making it essential to understand how plants, particularly alfalfa, resist drought for better crop yields in arid areas.
- In this study, different alfalfa cultivars (G3, G8, LD) were analyzed, revealing that the strongly drought-resistant cultivar Longdong exhibited superior enzymatic and protein responses compared to the other two cultivars under drought conditions.
- The research identified key genes involved in drought response related to mechanisms like phenylpropanoid and flavonoid biosynthesis, suggesting potential genetic modifications for improving alfalfa's drought resistance through molecular-assisted breeding.
Article Synopsis
- PCBs and OCPs are persistent chemicals found in the Arctic environment, influenced by geochemical cycles, and their behaviors have been studied in various research projects.
- Despite their historical presence, the concentrations of these chemicals are generally decreasing over time, showing no significant ecological risk in soil or sediment when compared to set standards.
- However, certain chemicals like DDT and HCB showed increased concentrations with higher trophic levels, indicating a need for more research on the long-term impacts of these contaminants.
Article Synopsis
- The study explored the link between a proteomic signature related to body mass index (BMI) and the risk of major cardiovascular diseases (CVD), focusing on ischemic heart disease (IHD) and heart failure (HF).
- Analyzing data from over 40,000 participants, researchers found that higher pro-BMI scores were associated with increased risks of IHD and HF, independent of actual BMI, with specific hazard ratios indicating substantial risk for both conditions.
- The results suggest that measuring plasma proteins in relation to BMI could help in better diagnosing obesity and tailoring personalized treatments for cardiovascular risks.
Article Synopsis
- This study explores the link between the advanced lung cancer inflammation index (ALI) and the prevalence of non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis (AF) using data from 5642 individuals in the NHANES survey.
- Researchers used statistical models to analyze if higher ALI levels correlate with increased occurrences of NAFLD and AF, while also looking at the role of lipid biomarkers like total cholesterol and HDL-C.
- The results indicated a significant positive relationship between higher ALI levels and the likelihood of having NAFLD and AF, with a specific inflection point noted for NAFLD, and highlighted that lipid levels partly mediate this association.
Thermoelectrics (TEs), enabling the direct conversion between heat and electrical energy, have demonstrated extensive application potential in biomedical fields. Herein, the mechanism of the TE effect, recent developments in TE materials, and the biocompatibility assessment of TE materials are provided. In addition to the fundamentals of TEs, a timely and comprehensive review of the recent progress of advanced TE materials and their applications is presented, including wearable power generation, personal thermal management, and biosensing.
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- The study investigates how different pig breeds (Duroc, Yorkshire, and Landrace) affect gut microbial diversity and metabolite profiles, using sequencing and untargeted metabolomics methods.
- Results show significant differences in gut microbiomes among the breeds, with specific microorganisms linked to backfat thickness, which can serve as biomarkers for improving pig production traits.
- The findings suggest that the interplay between gut microbiota and metabolites is essential for understanding breed-specific health and production characteristics in commercial pigs.
[Strategies for prevention and treatment of vascular and nerve injuries in mandibular anterior implant surgery].
Zhejiang Da Xue Xue Bao Yi Xue Ban
October 2024
Article Synopsis
- Important anatomical structures in the mandibular anterior region can be damaged during implant surgery, potentially leading to serious complications like hematoma, asphyxia, and nerve injuries.
- The risks are heightened due to insufficient alveolar bone space and variations in blood vessels and nerves, necessitating careful consideration during surgery.
- To prevent injuries, it's crucial for surgeons to understand the anatomy, utilize cone-beam computed tomography, and employ digital technology for precise implant placements, while also having strategies for management if injuries occur.
Hearing results following endoscopic type I tympanoplasty in medium and large perforations.
Braz J Otorhinolaryngol
January 2025
Article Synopsis
- The study aimed to evaluate hearing outcomes after endoscopic type I tympanoplasty in patients with medium and large eardrum perforations caused by chronic otitis media.
- A total of 156 patients were analyzed, revealing improvements in air conduction thresholds post-surgery for both medium and large perforation groups, with no significant differences between them.
- Bone conduction thresholds showed no significant changes post-operation, except for a slight improvement at 4000 Hz, indicating that tympanosclerosis had minimal impact on overall hearing outcomes.
For autoimmune disease (AD) and autoinflammatory disease (AID)-related haemophagocytic lymphohistiocytosis (HLH) (AD/AID-HLH), there is still a lack of standardized treatment. Glucocorticoids (GCs) are the main treatment currently; however, 37.9% to 61% of patients fail to achieve effective control of HLH, making it urgent to find novel treatment strategies.
View Article and Find Full Text PDFHigh concentration Ca in karst soil is harmful to agriculture. Some dominant plants can adapt well to karst soil, but how Ca affect plant is unknown. is a Ca-tolerant fern and its dry rhizome is a common Chinese medicine of Miao nationality in Guizhou, China.
View Article and Find Full Text PDFA case report: Comorbidity of Rhinocerebral mucormycosis and pulmonary aspergillosis with challenging diagnosis.
Front Med (Lausanne)
September 2024
Article Synopsis
- - Mucormycosis, specifically rhinocerebral mucormycosis (RCM), is a rare and serious fungal infection that is often difficult to diagnose, leading to high mortality rates due to delays.
- - A case study highlighted a patient with both pulmonary aspergillosis and RCM, where the diagnosis was confirmed through advanced metagenomic Next-Generation Sequencing (mNGS), but despite aggressive treatment, the patient died.
- - The study concludes that early and accurate diagnosis of RCM is crucial due to its rapid progression, and mNGS can be particularly useful when traditional testing methods fail to identify the infection.
Article Synopsis
- The study aimed to validate a blepharo-tensiometer and examine the link between eyelid pressure (ELP) and corneal health metrics like tomography and biomechanics.
- Researchers evaluated the repeatability and reproducibility of the tensiometer across different angles and operators while measuring various ocular parameters in 36 eyes from different subjects.
- Results indicated the tensiometer had good precision, showing that increased ELP correlates with improved corneal biomechanical properties, which could have implications for understanding corneal disorders.
Regulating the coupled relationship among water, nitrogen, and biochar is an effective strategy for increasing production and reducing emissions in greenhouse agriculture. However, a comprehensive evaluation model remains lacking. Toward this end, we aimed to evaluate the emission patterns of greenhouse gases and greenhouse tomato yield during the spring and autumn cultivation seasons as influenced by irrigation water use efficiency, nitrogen fertilizer partial productivity, and soil organic carbon (SOC).
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- The study analyzes lymph node counts in patients with locally advanced rectal cancer after receiving total neoadjuvant therapy (TNT) and examines their impact on survival rates.
- Conducted as a post-hoc analysis of the STELLAR trial, the research distinguishes between limited and extended lymphadenectomy based on lymph node harvest and evaluates their effects on overall survival and disease-free survival.
- Results show that patients with limited lymphadenectomy had significantly worse survival outcomes, while adjuvant chemotherapy generally improved survival, though the benefits were not significant in the extended lymphadenectomy subgroup.
Cisplatin resistance is one of the major causes of treatment failure in head and neck squamous cell carcinoma (HNSCC). There is an urgent need to uncover the underlying mechanism for developing effective treatment strategies. A quantitative proteomics assay was used to identify differential proteins in cisplatin-resistant cells.
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- This study examines how middle-aged adults accept AI chatbots in healthcare and identifies factors influencing this acceptance, highlighting the need for more research in this area.
- Using a survey based on the Technology Acceptance Model 2 (TAM2), the research analyzed data from 259 participants, revealing that ease of use, social norms, and user image significantly impact the intention to use AI chatbots.
- The findings suggest that perceived usefulness strongly affects user perceptions and indicate a moderate acceptance level of AI chatbots among middle-aged adults, pointing to the necessity for tailored interventions to enhance AI technology adoption.
Article Synopsis
- Immune metabolism involves various metabolic pathways like glycolysis, TCA cycle, and fatty acid oxidation, which are crucial for cell growth and regulating cellular functions.
- Macrophage metabolism is key in tissue repair, with proinflammatory M1 macrophages relying on glycolysis and TCA, while anti-inflammatory M2 macrophages use the TCA cycle alongside fatty acid oxidation and oxidative phosphorylation.
- The article reviews the roles of glucose, lipid, and amino acid metabolism in macrophages, highlighting the need for further research in their mechanisms during tissue repair and regeneration.
Article Synopsis
- The study aimed to compare the effects of NiTi closed-coil springs and elastomeric chains on apical root resorption and alveolar bone changes after maxillary canine closure in patients with Angle Class I malocclusion.
- A randomized clinical trial involving 31 adults used cone-beam computed tomography and cephalometric radiographs before and after treatment to measure the outcomes.
- Both appliances caused similar tooth root resorption, with no statistically significant difference in root length change; however, both treatments positively affected alveolar bone levels significantly.
Article Synopsis
- Oxalate nephropathy involves calcium oxalate crystals that cause damage to renal cells and trigger inflammation; the exact mechanisms, particularly relating to immune cell involvement, are not fully understood.
- This study tested the hypothesis that NINJ1, which causes membrane rupture and releases inflammatory signals, plays a key role in worsening kidney damage during oxalate nephropathy.
- Results show that deleting Ninj1 in immune cells reduces kidney injury by lowering harmful signals and cell death, highlighting the importance of NINJ1 in this type of kidney disease.