Transitions experienced by people living with limitations resulting from leprosy: a research-care study.

Objective: to understand the transitional processes that affect the adaptation of people who live with limitations resulting from leprosy.

Methods: This is a qualitative study based on the precepts of Transition Theory, mediated by care-research, with 24 people with limitations resulting from leprosy in an ex-hospital colony in Piauí. Semi-structured interviews were carried out.

High Expression of GABA Receptor β Subunit Genes Is Associated with Longer Overall Survival in Medulloblastoma.

Most of the rapid inhibitory neurotransmission in the brain is mediated through activation of the γ-aminobutyric acid (GABA) type A (GABA) receptor, which is a ligand-gated ion channel. GABA receptor activation via GABA binding allows for an intracellular influx of Cl ions, thus inducing cellular hyperpolarization. Each GABA receptor consists of a combination of five subunits, and several subunits have been proposed as biomarkers and therapeutic targets in cancer.

Which Encoding Techniques Facilitate Comprehension?

Previous work suggests that similar cognitive processes contribute to memory and comprehension. This is unsurprising as both begin with a common process: encoding. Despite this, the investigation of techniques that benefit memory and comprehension has proceeded separately.

Effectiveness of production and drawing as encoding techniques on recall using mixed- and pure-list designs.

We compared the benefit of production and drawing on recall of concrete and abstract words, using mixed- and pure-list designs. We varied stimulus and list types to examine whether the memory benefit from these strategies was sustained across these manipulations. For all experiments, the memory retrieval task was free recall.

How varying cue duration influences item-method directed forgetting: A novel selective retrieval interpretation.

A series of four experiments tested the assumptions of the most prominent and longstanding account of item-method directed forgetting: the selective rehearsal account. In the item-method directed forgetting paradigm, each presented item is followed by its own instructional cue during the study phase - either to-be-forgotten (F) or to-be-remembered (R). On a subsequent test, memory is poorer for F items than for R items.

Next-generation pediatric care: nanotechnology-based and AI-driven solutions for cardiovascular, respiratory, and gastrointestinal disorders.

Background: Global pediatric healthcare reveals significant morbidity and mortality rates linked to respiratory, cardiac, and gastrointestinal disorders in children and newborns, mostly due to the complexity of therapeutic management in pediatrics and neonatology, owing to the lack of suitable dosage forms for these patients, often rendering them "therapeutic orphans". The development and application of pediatric drug formulations encounter numerous challenges, including physiological heterogeneity within age groups, limited profitability for the pharmaceutical industry, and ethical and clinical constraints. Many drugs are used unlicensed or off-label, posing a high risk of toxicity and reduced efficacy.

Factors associated with workaholism in nurses' mental health: integrative review.

Objective: to synthesize the main scientific evidence available on the factors associated with workaholism in nurses' mental health.

Method: this is an integrative review carried out in seven databases. The sample consisted of 11 studies.

A case for using methods from natural science in advancing the field of cognitive neuroscience.

Cognitive neuroscience seeks to pinpoint the neural basis of cognitive function. Application of scientific methods can be credited for its advancement within the field of psychology. Past approaches such as phrenology, that linked bumps on the skull to mental capabilities, initially gained popularity, but the lack of experimental testing contributed to its demise.

The impact of probiotics on antibiotic resistance in newborns: A systematic review.

Background And Objectives: Newborns, particularly premature ones, are vulnerable to bacterial infections and often receive antibiotics, disrupting their normal intestinal microbiota. Probiotics have multiple health benefits and are recommended for restoring balance, but caution is needed due to potential consequences, such as promoting antibiotic resistance. Therefore, this study aimed to conduct a systematic review to assess current knowledge regarding the impact of probiotics on antibiotic resistance in newborns.

Long-term cognitive and affective consequences of mild traumatic brain injury: comparison with older adults.

Objective: Memory and affective processing were compared in young adults with a remote mild traumatic brain injury (mTBI), to healthy younger and older adults. We evaluated memory performance when encoding was done under multi-tasking (divided attention) conditions, likely to exacerbate cognitive and psychological symptoms in mTBI.

Methods: Participants studied pairs of unrelated words under either full or divided attention conditions.

Deepvirusclassifier: a deep learning tool for classifying SARS-CoV-2 based on viral subtypes within the coronaviridae family.

Purpose: In this study, we present DeepVirusClassifier, a tool capable of accurately classifying Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) viral sequences among other subtypes of the coronaviridae family. This classification is achieved through a deep neural network model that relies on convolutional neural networks (CNNs). Since viruses within the same family share similar genetic and structural characteristics, the classification process becomes more challenging, necessitating more robust models.

SHA-256 Hardware Proposal for IoT Devices in the Blockchain Context.

This work proposes an implementation of the SHA-256, the most common blockchain hash algorithm, on a field-programmable gate array (FPGA) to improve processing capacity and power saving in Internet of Things (IoT) devices to solve security and privacy issues. This implementation presents a different approach than other papers in the literature, using clustered cores executing the SHA-256 algorithm in parallel. Details about the proposed architecture and an analysis of the resources used by the FPGA are presented.

Brain regions supporting retrieval of words drawn at encoding: fMRI evidence for multimodal reactivation.

Memory for words that are drawn or sketched by the participant, rather than written, during encoding is typically superior. While this drawing benefit has been reliably demonstrated in recent years, there has yet to be an investigation of its neural basis. Here, we asked participants to either create drawings, repeatedly write, or list physical characteristics depicting each target word during encoding.

Interaction between methanotrophy and gastrointestinal nematodes infection on the rumen microbiome of lambs.

Complex cross-talk occurs between gastrointestinal nematodes and gut symbiotic microbiota, with consequences for animal metabolism. To investigate the connection between methane production and endoparasites, this study evaluated the effect of mixed infection with Haemonchus contortus and Trichostrongylus colubriformis on methanogenic and methanotrophic community in rumen microbiota of lambs using shotgun metagenomic and real-time quantitative PCR (qPCR). The rumen content was collected from six Santa Inês lambs, (7 months old) before and after 42 days infection by esophageal tube.

Stemness and Cell Cycle Regulators and Their Modulation by Retinoic Acid in Ewing Sarcoma.

Retinoic acid (RA) regulates stemness and differentiation in human embryonic stem cells (ESCs). Ewing sarcoma (ES) is a pediatric tumor that may arise from the abnormal development of ESCs. Here we show that RA impairs the viability of SK-ES-1 ES cells and affects the cell cycle.

Recurrent involuntary memories and mind wandering are related but distinct.

Spontaneous thought is common in daily life, and includes recurrent involuntary autobiographical memories (IAMs; memories retrieved unintentionally and repetitively) and mind wandering (MW). Both recurrent IAMs and MW are often unintentional or unconstrained, and both predict symptoms of mental health disorders. However, not all MW is unintentional, and not all IAMs are unconstrained.

Specific topics, specific symptoms: linking the content of recurrent involuntary memories to mental health using computational text analysis.

Researchers debate whether recurrent involuntary autobiographical memories (IAMs; memories of one's personal past retrieved unintentionally and repetitively) are pathological or ordinary. While some argue that these memories contribute to clinical disorders, recurrent IAMs are also common in everyday life. Here, we examined how the content of recurrent IAMs might distinguish between those that are maladaptive (related to worse mental health) versus benign (unrelated to mental health).

Corrigendum: Evolutionary tracks of chromosomal diversification in surgeonfishes (Acanthuridae: ) along the world's biogeographic domains.

[This corrects the article DOI: 10.3389/fgene.2021.

Disentangling boredom from depression using the phenomenology and content of involuntary autobiographical memories.

Recurrent involuntary autobiographical memories (IAMs) are memories retrieved unintentionally and repetitively. We examined whether the phenomenology and content of recurrent IAMs could differentiate boredom and depression, both of which are characterized by affective dysregulation and spontaneous thought. Participants (n = 2484) described their most frequent IAM and rated its phenomenological properties (e.