Explicit solvation thermodynamics in ionic solution: extending grid inhomogeneous solvation theory to solvation free energy of salt-water mixtures.

Hydration thermodynamics play a fundamental role in fields ranging from the pharmaceutical industry to environmental research. Numerous methods exist to predict solvation thermodynamics of compounds ranging from small molecules to large biomolecules. Arguably the most precise methods are those based on molecular dynamics (MD) simulations in explicit solvent.

Serum oxLDL-β2GPI complex reflects metabolic syndrome and inflammation in adipose tissue in obese.

Background/objectives: OxLDL-β2GPI complex has been suggested to have a role in the development of atherosclerosis and other inflammatory diseases. The aim of this study was to investigate the possible association of circulating oxLDL-β2GPI with obesity-induced inflammatory state of adipose tissue and related comorbidities as metabolic syndrome development.

Subjects/methods: Two cohorts of subjects were examined in the study.

Higher insulin sensitivity in vegans is not associated with higher mitochondrial density.

Background/objectives: Vegans have a lower incidence of insulin resistance (IR)-associated diseases and a higher insulin sensitivity (IS) compared with omnivores. The aim of this study was to examine whether the higher IS in vegans relates to markers of mitochondrial biogenesis and to intramyocellular lipid (IMCL) content.

Subjects/methods: Eleven vegans and 10 matched (race, age, sex, body mass index, physical activity and energy intake) omnivorous controls were enrolled in a case-control study.

The dissolution and bioavailability of etodolac from capsules exposed to conditions of high relative humidity and temperatures.

The dissolution and bioavailability of etodolac from capsules exposed to high relative humidity and temperature were compared to those from capsules stored at room temperature (RT). Dissolution of stressed and control capsules was evaluated using a USP basket apparatus at 100 rpm with 900 mL pH 7.5 phosphate buffer (0.

Phototoxic and photochemical properties of sanguinarine.

Sanguinarine, a commercial drug exhibiting antimicrobial and antitumor properties, was studied with respect to its basic photochemical characteristics and also with regard to its phototoxicity to mosquito larvae (Aedes atropalpus). Sanguinarine proved to be clearly phototoxic to larvae, with an LD50 of 0.096 mg/mL with near UV exposure as compared with 23.

Effect of hydrocortisone on the desialylation of intestinal brush-border enzymes of the rat during postnatal development.

Hydrocortisone acetate or hemisuccinate (75 mg/kg body mass) applied to rats i.m. and/or s.

[Control mechanisms of the ribonucleotide reduction in mammalian tissue (author's transl)].

The ribonucleoside diphosphate reductase (E.C.1.

[Studies on the thymidine-triphosphate synthesis in malignant tumors. I. Effects of thymidine on deoxyribonucleoside triphosphate pools and deoxyribonucleic acid synthesis (author's transl)].

Measurements of the deoxyribonucleoside triphosphate (dNTP) contents, the [14C] thymidine and deoxyuridine incorporation and the "key enzymes" of the thymidine triphosphate (dTTP) synthesis, thymidine kinase and ribonucleotide reductase, in diploid Ehrlich-ascites carcinoma, in Yoshida sarcoma-ascites cells and to a smaller extent in surgically removed malignant human tumours show 1. A distinctly increased dTTP content compared with the remaining dNTP is not a characteristic of tumour cells generally but a peculiarity of sarcoma and a sign of differentiation of a malignant tumour. 2.

Specificity of the interation of thyroxine with rat adenohypophyseal proteins.

The proportion of thyroxine specifically bound to the proteins of the control and the oestrogenized rat adenohypophysis was estimated by determining the rate of ligand exchange, which was found to be higher in the oestrogenized adenohypophysis. The dissociation constants of this interaction were determined by analyzing saturation of the binding proteins with mounting labelled thyroxine concentrations and with a mixture of labelled and unlabelled thyroxine, using the equilibrium-maintaining batchwise Amberlite method. K(dis) for the interaction of thyroxine with the proteins of the control adenohypophysis was 6 X 10(-8) M and K(dis) for its interaction with the proteins of the oestrogenized adenohypophysis was 2.