Unveiling the impact of pipe materials on water hammer in pressure pipelines: an experimental and numerical study.

Water hammer (WH) is a phenomenon characterized by the rapid opening or closing of valves or pumps in pipelines, resulting in a disruptive noise, intense vibrations, and potential damage to pipes, fittings, structures, and even human safety. While WH arresters are commonly employed to mitigate this issue in smaller plumbing systems, alternative solutions are required for larger applications like power plants. Researchers have proposed the utilization of pipe materials with a low modulus of elasticity in areas prone to WH events, as these materials possess the capability to absorb a significant portion of the resulting vibrations.

Phytochemical analysis and wound healing properties of Malva parviflora L. ethanolic extract.

Ethnopharmacological Relevance: Scientific publications documented the use of plants from Genus Malva to treat inflammatory diseases and skin disorders by our ancestors. Malva parviflora L. has reported benefits for wound healing in traditional medicine; however, there is a lack of experimental study to validate these claims.

Trastuzumab Deruxtecan with Nivolumab in HER2-Expressing Metastatic Breast or Urothelial Cancer: Analysis of the Phase Ib DS8201-A-U105 Study.

Purpose: This multicenter phase Ib study investigated trastuzumab deruxtecan (T-DXd) plus nivolumab in patients with HER2-expressing metastatic breast cancer (mBC) and metastatic urothelial cancer (mUC).

Patients And Methods: Part 1 determined the recommended dose for expansion of T-DXd plus nivolumab. Part 2 evaluated efficacy and safety; the primary endpoint was confirmed objective response rate by independent central review.

A new cleaning method for solar panels inspired from the natural vibrations of tree branches and leaves.

Photovoltaic (PV) panels are similar in many aspects to the leaves of trees, both are standing in the Sun to capture the sunlight, however, PV panels get soiled especially in desert areas, while the leaves remain clean to a very good extent. The question is, why leaves remain clean while PV panels get soiled quite easily? The leaves are hanging on the stem of trees and these stems are flexible to motion, such that if the wind blows in any direction over the stem it vibrates allowing any deposited particle to fall off the surface. The objective of this research is to develop a fixation method for PV panels similar to the stems of trees, such that the panel can vibrate as the wind blows in order to minimize dust accumulation.

Evaluating the Efficacy and Safety of Robotic Versus Conventional Completion Thyroidectomy: A 10-year Experience.

Background: Robotic thyroidectomy is gaining popularity, yet its role in completion thyroidectomy remains unclear. We aimed to compare robotic vs conventional completion thyroidectomy for thyroid nodules.

Methods: This retrospective study analyzed patients undergoing completion thyroidectomy from 2010-2020, either by conventional open technique (n = 87) or a robotic remote-access approach (n = 44).

A prototype system for the removal of Cs from liquid radioactive waste using reverse osmosis membrane.

Cesium removal from aqueous solutions of radioactive waste streams is a challenge in the field of radioactive waste management; this is due to the small atomic radii of Cs metal ions and their high migration ability. So, the development of a withstand system for the removal of Cs is crucial. In the current study, the removal of radioactive cesium from aqueous solutions using an RO-TLC membrane was studied.

Effect of melatonin on developmental competence, mitochondrial distribution, and intensity of fresh and vitrified/thawed in vitro matured buffalo oocytes.

In livestock breeding, oocyte cryopreservation is crucial for preserving and transferring superior genetic traits. This study was conducted to examine the additional effect of melatonin to maturation and vitrification media on the in vitro developmental capacity, mitochondrial distribution, and intensity of buffalo oocytes. The study involved obtaining ovaries from a slaughterhouse and conducting two phases.

A comprehensive study for the potential removal of Eu radionuclides using a promising modified strontium-based MOF.

A facile modification of a strontium-based MOF using oxalic acid was carried out to prepare MTSr-OX MOF, which was used as a potential substance for eliminating Eu radioisotopes. Various analytical techniques were used to characterize MTSr-OX-MOF. The prepared MOF had a rod-like structure with a BET surface area of 101.

Effects of Prolonged Fasting during Inpatient Multimodal Treatment on Pain and Functional Parameters in Knee and Hip Osteoarthritis: A Prospective Exploratory Observational Study.

Preliminary clinical data suggest that pain reduction through fasting may be effective for different diagnoses. This uncontrolled observational clinical study examined the effects of prolonged modified fasting on pain and functional parameters in hip and knee osteoarthritis. Patients admitted to the inpatient department of Internal Medicine and Nature-based Therapies of the Immanuel Hospital Berlin between February 2018 and December 2020 answered questionnaires at the beginning and end of inpatient treatment, as well as at 3, 6, and 12 months after discharge.

Design, synthesis, anticancer, and antibacterial evaluation of some quinazolinone-based derivatives as DHFR inhibitors.

Two series of quinazolinone derivatives were designed and synthesized as dihydrofolate reductase (DHFR) inhibitors. All compounds were evaluated for their antibacterial and antitumor activities. Antibacterial activity was evaluated against three strains of Gram-positive and Gram-negative bacteria.

Numerical investigation of the effect of dust shields on accumulation of dust over PV panels.

Dust accumulation on photovoltaic panels represents a major challenge for the operation of solar panels especially in the regions known by their high rate of dust and low frequency of rain. The objective of this study is to minimize dust accumulation on PV panels operating street light posts using dust shields. A novel dust shield having the same width of the panel, and subtending an angle of 120° with the panel, is proposed for dust mitigation.

GC/MS Profiling of the Essential Oil and Lipophilic Extract of Boiss. and Evaluation of Their Cytotoxic and Antioxidant Activities.

The genus (Brassicaceae) comprises about eight species that were used in traditional medicine. is used to alleviate certain disorders such as syphilis and exhibits analgesic, anti-inflammatory, antipyretic, antioxidant, and antigenotoxic properties. Throughout this study, we aimed to figure out the chemical composition of lipophilic extract and essential oil obtained from aerial parts using GC/MS analysis, as well as their cytotoxic and antioxidant activities correlated with the major detected compounds' molecular docking.

Post Hoc Analysis of a Randomized Controlled Trial on Fasting and Plant-Based Diet in Rheumatoid Arthritis (NutriFast): Nutritional Supply and Impact on Dietary Behavior.

This study aimed at comparing the nutrient supply and dietary behaviors during a plant-based diet (PBD) combined with time-restricted eating (TRE) to standard dietary recommendations in rheumatoid arthritis patients. In this open-label, randomized, controlled clinical trial, patients were assigned to either a 7-day fast followed by an 11-week PBD including TRE (A) or a 12-week anti-inflammatory diet following official German guidelines (German Nutrition Society, DGE) (B). Dietary habits were assessed by 3-day food records at weeks -1, 4 and 9 and food frequency questionnaires.

Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR-2 and DNA gyrase inhibition, and in silico studies.

A series of coumarin derivatives were designed, synthesized, and evaluated for their antiproliferative activity. Compound 3e exhibited significant antiproliferative activity and was further evaluated at five doses at the National Cancer Institute. It effectively inhibited vascular endothelial growth factor receptor-2 (VEGFR-2) with an IC value of 0.

Effect of some agricultural treatments on the Egyptian alfalfa weevil, Hypera brunneipennis and their economic evaluation on yield and yield components in Egypt.

Background: The Egyptian alfalfa weevil, Hypera brunneipennis causes damage on different parts of alfalfa plants. Therefore, four agricultural treatments are carried out included calcium super phosphate addition (15.5% P O ), potassium sulphate addition (50% K O), microelements spraying and hand removing of weeds to reduce the population of the Egyptian alfalfa weevil and increase both the final yield and obtain a healthy plant.

Neoadjuvant endocrine therapy with or without palbociclib in low-risk patients: a phase III randomized double-blind SAFIA trial.

Background: The most prevalent subtype of breast cancer (BC) is luminal hormonal-positive breast cancer. The neoadjuvant chemotherapy regimens have side effects, emphasizing the need to identify new startegies.

Objective: Analyze the complete pathologic response (pCR) rate and overall response in a low-risk hormone-positive subset of patients receiving neoadjuvant hormone treatment (NAHT) with or without Palbociclib (a CDK4/CDK6 inhibitor) to boost NAHT effectiveness.

Targeted GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma.

GATA3 gene silencing in activated T cells displays a promising option to early-on undermine pathological pathways in the disease formation of allergic asthma. The central transcription factor of T helper 2 (Th2) cell cytokines IL-4, IL-5, and IL-13 plays a major role in immune and inflammatory cascades underlying asthmatic processes in the airways. Pulmonary delivery of small interfering RNAs (siRNA) to induce GATA3 knockdown within disease related T cells of asthmatic lungs via RNA interference (RNAi) presents an auspicious base to realize this strategy, however, still faces some major hurdles.

Boswellic acid coated zinc nanoparticles attenuate NF-κB-mediated inflammation in DSS-induced ulcerative colitis in rats.

Introduction: Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease, and until now therapeutic agents for UC still cannot exert satisfied effects. Therefore, this study aimed to investigate the ameliorative effect of boswellic acid coated zinc nanoparticles (BAs-ZnNPs) on dextran sodium sulphate (DSS) induced-UC in rats.

Methods: Rats were divided into five groups; control, BAs-ZnNPs, DSS, DSS+BAs, and DSS + BAs-ZnNPs.

The Role of miRNA-182 and FOXO3 Expression in Breast Cancer.

Objective: evaluating the role of FOXO3 mRNA and mi RNA 182-5P expression levels in BC patients.

Method: 25 Samples of breast cancer and paired samples of non-cancerous tissues from the same resected breast were obtained from 25 female patients suffering from breast cancer and examined and analyzed by real time PCR to detect the expression levels of FOXO3 mRNA and mi RNA 182-5P. Patients' data were collected from patients medical records.

Computational prediction of dust deposition on solar panels.

This research is concerned with performing computational fluid dynamics (CFD) simulations to investigate the air flow and dust deposition behavior around a ground-mounted solar PV panel. The discrete phase model (DPM) is adopted to model the gas-solid flow. The influence of the wind speed, the dust particle size, and the dust material on the dust deposition rate was investigated based on the environment of Cairo, Egypt.

A Sisyphean Task for Residents: Preparing Literature Reviews About Adverse Events Presented at Morbidity and Mortality Conferences.

Objective: Surgery Morbidity and Mortality (M&M) presentations include a thorough literature review. This requires a significant amount of time expenditure frequently incompatible with the current surgical resident work hours. Additionally, literature reviews can be redundant for commonly encountered adverse events.

Patient-Centered Outcomes in a Randomized Trial Investigating a Multimodal Prevention Program After Transient Ischemic Attack or Minor Stroke: The INSPiRE-TMS Trial.

Background: The INSPiRE-TMS trial (Intensified Secondary Prevention Intending a Reduction of Recurrent Events in Transient Ischemic Attack and Minor Stroke Patients) investigated effects of a multicomponent support program in patients with nondisabling stroke or transient ischemic attack. Although secondary prevention targets were achieved more frequently in the intensified care group, no significant differences were seen in rates of recurrent major vascular events. Here, we present the effects on prespecified patient-centered outcomes.

A novel strontium-based MOF: synthesis, characterization, and promising application in removal of Eu from active waste.

Removal of hazardous radioactive materials such as Eu from active waste using the batch approach has attracted attention nowadays. In this work, a novel melamine-terephthalic strontium metal-organic framework (MTSr-MOF) was prepared a hydrothermal method. The MTSr-MOF was characterized by various analytical techniques such as FT-IR, H/C-NMR, mass spectroscopy, XPS, XRD, TGA, BET, FE-SEM/EDX, TEM, and UV.

Facile auto-combustion synthesis of calcium aluminate nanoparticles for efficient removal of Ni(II) and As(III) ions from wastewater.

We herein report the synthesis of monoclinic calcium aluminate (CaAlO) nanoparticles via a facile auto-combustion method followed by calcination. We performed the auto-combustion method using aluminium nitrate and calcium nitrate as oxidants and different fuels as reductants such as urea, glycine, and a mixture of urea and glycine, with various fuel-to-oxidant equivalence ratios . Then, the combusted samples were calcined at different temperatures; 600 and 800 °C.