Publications by authors named "M-Y Hua"
Objective: To compare survival effects of comprehensive neck dissection (CND) and selective neck dissection (SND) for patients with nasopharyngeal carcinoma (NPC) with only regional failure.
Methods: A total of 294 recurrent T0N1-3M0 NPC patients who underwent neck dissection in Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China, between January 1984 and February 2014, were enrolled in the survival and interaction analyses. Using propensity scores to adjust for potential prognostic factors, an additional well-balanced cohort of 210 patients was constructed by matching each patient who received SND with one patient who underwent CND (1:1); the differences were then compared between SND and CND in terms of overall survival (OS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), and distant metastasis-free survival (DMFS).
Article Synopsis
- The study investigates the neddylation pathway in glioblastoma (GBM) and its potential as a target for cancer therapy using MLN4924, a specific inhibitor.
- The analysis shows that the neddylation pathway is overactivated in most GBM tissues, correlating with aggressive disease and poor patient outcomes.
- Treatment with MLN4924 leads to reduced tumor growth and triggers tumor-suppressive mechanisms, suggesting that neddylation inhibition could be a promising new treatment strategy for GBM.
Sex-related differences in fractional flow reserve-guided treatment.
Circ Cardiovasc Interv
December 2013
Background: Sex-specific differences affect the evaluation, treatment, and prognosis of coronary artery disease. We tested the hypothesis that long-term outcomes of fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) are different between women and men.
Methods And Results: Consecutive 1090 patients, referred for PCI and undergoing FFR measurements at the Mayo Clinic between October 2002 and December 2009, were included in this registry study.