Publications by authors named "M-R Huo"
Article Synopsis
- Patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) have limited treatment options, prompting the investigation of magrolimab (M) combined with rituximab (R), and M combined with gemcitabine-oxaliplatin (M+R-GemOx) for long-term disease control.
- In a study involving 132 patients, M+R achieved an objective response rate (ORR) of 24%, while M+R-GemOx showed a higher ORR of 52%, with notable complete response (CR) rates of 12% and 39%, respectively.
- Both treatments were generally well tolerated, though common side effects included fatigue and anemia, with
Article Synopsis
- R/R indolent non-Hodgkin lymphoma (iNHL) is often deemed incurable, but a phase 1b/2 study found that combining magrolimab (an anti-CD47 antibody) with rituximab (an anti-CD20 antibody) shows promising antitumor effects.
- In this study, 46 patients were treated and showed a 52.2% overall response rate, with 30.4% achieving a complete response and median duration of response at 15.9 months.
- Long-term follow-up (median 36.7 months) revealed no new toxicities or treatment-related deaths, indicating the combination's long-term safety and effectiveness, encouraging further research into CD
Article Synopsis
- Triple-negative breast cancer (TNBC) patients often undergo neoadjuvant systemic therapy (NAST) to improve treatment outcomes.
- A study analyzed multiparametric MRI scans from 163 TNBC patients at different stages of NAST to see if radiomic models could predict the likelihood of achieving a pathologic complete response (pCR).
- The best predictive model, based on changes in MRI features after two cycles of treatment, showed a strong ability to forecast pCR with high accuracy, indicating that MRI could be useful for early treatment response assessments in TNBC.
Facile synthesis of MOF-808/RGO-based 3D macroscopic aerogel for enhanced photoreduction CO.
J Colloid Interface Sci
August 2024
Three-dimensional (3D) macroscopic aerogels have emerged as a critical component in the realm of photocatalysis. Maximizing the integration of materials can result in enhanced efficiency and selectivity in photocatalytic processes. In this investigation, we fabricated MOF-808/reduced graphene oxide (RGO) 3D macroscopic aerogel composite materials employing the techniques of hydrothermal synthesis and freeze-drying.
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- The study aimed to evaluate if a radiomics model using synthetic MRI (SyMRI) can predict responses to neoadjuvant systemic therapy (NAST) in women with triple-negative breast cancer (TNBC).
- It involved 181 women who underwent SyMRI scans at the start and mid-treatment, analyzing tumor features extracted from the imaging to identify differences between patients who achieved pathologic complete response (pCR) and those who did not.
- Results indicated that the radiomic features from mid-treatment scans were better at predicting pCR, with the model achieving an area under the receiver operating characteristic curve (AUC) of up to 0.78 in training and 0.72 in testing cohorts, suggesting potential usefulness
Assessment of Response to Neoadjuvant Systemic Treatment in Triple-Negative Breast Cancer Using Functional Tumor Volumes from Longitudinal Dynamic Contrast-Enhanced MRI.
Cancers (Basel)
February 2023
Article Synopsis
- Early assessment of neoadjuvant systemic therapy (NAST) response is important for triple-negative breast cancer (TNBC) patients to prevent harmful side effects from ineffective treatments.
- The study evaluated functional tumor volumes (FTVs) using dynamic contrast-enhanced (DCE) MRI after the 2nd and 4th cycles of NAST in 100 patients, finding FTVs at these points could indicate treatment response.
- Results showed that 49% of patients achieved a pathologic complete response (pCR), with FTV at the 4th cycle having the best predictive accuracy (AUC = 0.84), while baseline FTV did not distinguish between pCR and non-pCR.
Background There is no consensus regarding the relative prognostic value of cardiac MRI and fluorodeoxyglucose (FDG) PET in cardiac sarcoidosis. Purpose To perform a systematic review and meta-analysis of the prognostic value of cardiac MRI and FDG PET for major adverse cardiac events (MACE) in cardiac sarcoidosis. Materials and Methods In this systematic review, MEDLINE, Ovid Epub, CENTRAL, Embase, Emcare, and Scopus were searched from inception until January 2022.
View Article and Find Full Text PDFBackground And Objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).
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- Racial and ethnic disparities in breast cancer mortality are increasing, yet genomic studies often overlook diverse populations, highlighting a gap in research.
- The study analyzed 194 breast cancer patients from Nigeria alongside 1,037 patients from The Cancer Genome Atlas (TCGA), revealing that Nigerian tumors have distinct genomic features indicating more aggressive cancer biology.
- Key findings include higher rates of specific mutations in Nigerian patients and the identification of novel genes linked to breast cancer, potentially paving the way for tailored treatments for underrepresented groups.