Publications by authors named "M-P Le Gac"
Article Synopsis
- A new water-soluble iron(III) tetraarylporphyrin structure was created to imitate myoglobin and stabilize oxygen binding in water, featuring unique side chains for enhanced function.
- It forms a stable complex with a modified β-cyclodextrin dimer, which provides a protective environment for the iron center and enables the binding of both oxygen and carbon monoxide.
- The new compound shows reduced binding affinities for CO and oxygen compared to a control compound without the strap structure, suggesting that the strap limits gas access while increasing selectivity for oxygen over carbon monoxide.
Background: Hepatocellular carcinoma (HCC) is an aggressive cancer with limited therapeutic options. Retrospective studies have shown that the administration of local anesthetics (LAs) during cancer surgery could reduce cancer recurrence. Besides, experimental studies reported that LAs could inhibit the growth of cancer cells.
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