Electronic structure of superconducting infinite-layer lanthanum nickelates.

Revealing the momentum-resolved electronic structure of infinite-layer nickelates is essential for understanding this class of unconventional superconductors but has been hindered by the formidable challenges in improving the sample quality. In this work, we report the angle-resolved photoemission spectroscopy of superconducting LaSrNiO films prepared by molecular beam epitaxy and in situ atomic-hydrogen reduction. The measured Fermi topology closely matches theoretical calculations, showing a large Ni [Formula: see text]-derived Fermi sheet that evolves from hole-like to electron-like along and a three-dimensional (3D) electron pocket centered at the Brillouin zone corner.

Triply Ordered 6H Halide Perovskites: A Family of Triangular Lattice Antiferromagnets.

Three new hexagonal perovskites with CsMMRhCl (M = Na, Ag; M = Mn, Fe) stoichiometry have been synthesized from solution precipitation reactions. These air-stable compounds crystallize as triply cation-ordered variants of the 6H perovskite structure. This structure contains octahedra that share a common face to form MRhCl dimers that are arranged on a two-dimensional triangular network.

Application of Deep Learning Accelerated Image Reconstruction in T2-weighted Turbo Spin Echo Imaging of the Brain at 7T.

Prolonged imaging times and motion sensitivity at 7T necessitate advancements in image acceleration techniques. This study evaluates a 7T deep-learning (DL)-based image reconstruction using a deep neural network trained on 7T data, applied to T2-weighted turbo spin echo imaging. Raw k-space data from 30 consecutive clinical 7T brain MRI patients was reconstructed using both DL and standard methods.

Robust dioxin-linked metallophthalocyanine tbo topology covalent organic frameworks and their photocatalytic properties.

Constructing 3D functional covalent organic frameworks (COFs) with both robust linkage and planar macrocycle building blocks still remains a challenge due to the difficulty in adjusting both the crystallinity and the dominant 2D structures. In addition, it is also challenging to selectively convert inert C(sp)-H bonds into value-added chemicals. Herein, robust 3D COFs, USTB-28-M (M=Co, Ni, Cu), have been polymerized from the nucleophilic aromatic substitution reaction of -symmetric 2,3,6,7,14,15-hexahydroxyltriptycene with -symmetric hexadecafluorophthalocyanine (MPcF) under solvothermal conditions.

Determination of Site Occupancy in the M-Pd-Zn (M = Cu, Ag, and Au) γ-Brass Phase by CALculation of PHAse Diagrams Modeling and Rietveld Refinement.

The Pd-Zn γ-brass phase provides exciting opportunities for synthesizing site-isolated catalysts with precisely controlled Pd active site ensembles. Introducing a third metallic element into the γ-brass lattice further perturbs the catalytic active site ensembles. Here, we introduce coinage metallic elements M (M = Cu, Ag, and Au) into the Pd-Zn γ-brass phase and investigate the site occupation factors of each element in the γ-brass lattice.

Identification of syncytiotrophoblast-derived cf-RNA OPA1 to predict the occurrence of preeclampsia.

Background: Pre-eclampsia (PE) poses a significant threat to mothers and infants worldwide. Studies indicate that taking low-dose aspirin before the 16th week of pregnancy may prevent approximately 70 % of PE cases, highlighting the importance of predicting PE. Cell-free RNA (cf-RNA) exhibits significant changes in the maternal peripheral blood during early pregnancy, making cf-RNA analysis a promising and less invasive method for predicting PE.

Characterizing mutation-treatment effects using clinico-genomics data of 78,287 patients with 20 types of cancers.

Evaluating the effectiveness of cancer treatments in relation to specific tumor mutations is essential for improving patient outcomes and advancing the field of precision medicine. Here we represent a comprehensive analysis of 78,287 U.S.

Tailoring a Transition Metal Dual-Atom Catalyst via a Screening Descriptor in Li-S Batteries.

The adsorption-conversion paradigm of polysulfides during the sulfur reduction reaction (SRR) is appealing to tackle the shuttle effect in Li-S batteries, especially based upon atomically dispersed electrocatalysts. However, mechanistic insights into such catalytic systems remain ambiguous, limiting the understanding of sulfur electrochemistry and retarding the rational design of available catalysts. Herein, we systematically explore the polysulfide adsorption-conversion essence via a geminal-atom model system to understand the catalyst roles toward an expedited SRR.

Structural and antigenic characterization of novel and diverse glycoproteins.

(HNVs), a genus within the family, includes the highly virulent Nipah and Hendra viruses that cause yearly reoccurring outbreaks of deadly disease. Recent discoveries of several new species, including the zoonotic Langya virus, have revealed much higher antigenic diversity than currently characterized. Here, to explore the limits of structural and antigenic variation in HNVs, we construct an expanded, antigenically diverse panel of HNV fusion (F) and attachment (G) glycoproteins from 56 unique HNV strains that better reflects global HNV diversity.

Favorable Outcomes of Patients With High-Risk Uveal Melanoma Treated With a Novel Linear Accelerator-Based Frameless Fractionated Stereotactic Radiosurgery.

Purpose: Uveal melanoma (UM) represents the most prevalent and aggressive intraocular malignancy in adults. This study examined the outcomes of patients diagnosed with high-risk UM who underwent fractionated stereotactic radiosurgery (fSRS) treatment utilizing a novel Linear Accelerator (LINAC)-based frameless technique.

Design: Retrospective, interventional case series.

Preclinical efficacy and safety of adeno-associated virus 5 alpha-galactosidase: A gene therapy for Fabry disease.

We developed a novel adeno-associated virus 5 gene therapy (AAV5-GLA) expressing human alpha-galactosidase A (GLA) under the control of a novel, small and strong, liver-restricted promoter. We assessed the preclinical potential of AAV5-GLA for treating Fabry disease, an X-linked hereditary metabolic disorder resulting from mutations in the gene encoding GLA that lead to accumulation of the substrates globotriaosylceramide and globotriaosylsphingosine, causing heart, kidney, and central nervous system dysfunction. Effects of intravenously administered AAV5-GLA were evaluated in (1) GLA-knockout mice aged 7-8 weeks (early in disease) and 20 weeks (nociception phenotype manifestation) and (2) cynomolgus macaques during an 8-week period.

Phase Ib/II study of imprime PGG and pembrolizumab in patients with previously treated advanced non-small cell lung cancer (NSCLC): BTCRC LUN 15-017.

Background: Therapeutic strategies to engage anti-tumor innate immunity are still underdeveloped. Imprime PGG (imprime), a pathogen-associated molecular pattern (PAMP), through pattern recognition receptors, successfully illicit a broad-based innate immune response in preclinical models against various cancers. We aimed to study safety and efficacy of imprime in combination with pembrolizumab in advanced stage non-small cell lung cancer (NSCLC).

π-HuB: the proteomic navigator of the human body.

The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual's body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies.

The Roles of Surface Hydrogen and Hydroxyl in Alkaline Hydrogen Oxidation on Ni-Based Electrocatalysts.

One important target for anion exchange membrane fuel cells (AEMFCs) is to enable the application of anode non-precious metal hydrogen oxidation reaction (HOR) catalyst. Nickel presents a promising candidate for alkaline HOR; yet, its practical application is hampered by the intrinsically sluggish activity and poor stability. Herein, a series of Ni-based metals (NiMo, NiCo, NiW and Ni) are electrodeposited as model catalysts to systematically explore the alkaline HOR by considering the role of adsorbed hydroxyl (OH).

Stat3 mediates Fyn kinase-driven dopaminergic neurodegeneration and microglia activation.

The Alzheimer's disease and Parkinson's disease risk locus FYN kinase is implicated in neurodegeneration and inflammatory signaling. To investigate in vivo mechanisms of Fyn-driven neurodegeneration, we built a zebrafish neural-specific Gal4:UAS model of constitutively active FynY531F signaling. Using in vivo live imaging, we demonstrated that neural FynY531F expression leads to dopaminergic neuron loss and mitochondrial aggregation in 5 day larval brain.

The adsorption mechanism and optimal dosage of walnut shell biochar for chloramphenicol.

Biochar derived from biomass pyrolysis has proven to be an excellent material for pesticide adsorption and can be used as soil amendment for pesticide non-point pollution. However, the adsorption and desorption mechanisms for certain biochar and pesticide are still unclear. In this study, we investigated the properties of biochar derived from walnut (Juglans regia L.

Unraveling the Diffusion MRI-Based Glymphatic System Alterations in Children with Rolandic Epilepsy.

Rationale And Objectives: Although dysfunction of the glymphatic system in adult epilepsy has been extensively studied, there is a lack of research on the changes in this system during childhood development, particularly in children with Rolandic epilepsy (RE). This study aimed to investigate the changes in diffusion MRI measures related to the glymphatic function in children with RE.

Materials And Methods: A total of thirty-eight children with RE and thirty-six demographically matched healthy children were enrolled in the study.

Middle Meningeal Artery Embolization for Nonacute Subdural Hematoma.

Background: The effect of embolization of the middle meningeal artery in patients with subacute or chronic subdural hematoma is uncertain.

Methods: We performed a multicenter, open-label, randomized trial in China, involving patients with symptomatic nonacute subdural hematoma with mass effect. Patients were assigned to undergo burr-hole drainage or receive nonsurgical treatment at the surgeon's discretion, and patients in each group were then randomly assigned, in a 1:1 ratio, to undergo middle meningeal artery embolization with liquid embolic material or to receive usual care.

Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma.

Background: Subacute and chronic subdural hematomas are common and frequently recur after surgical evacuation. The effect of adjunctive middle meningeal artery embolization on the risk of reoperation remains unclear.

Methods: In a prospective, multicenter, interventional, adaptive-design trial, we randomly assigned patients with symptomatic subacute or chronic subdural hematoma with an indication for surgical evacuation to undergo middle meningeal artery embolization plus surgery (treatment group) or surgery alone (control group).

The impact of MAFLD on coronary plaque characteristics and physiologic status: a coronary CT angiography study.

Rationale And Objectives: Metabolic dysfunction-associated fatty liver disease (MAFLD) is linked to an increased risk of cardiovascular events. Our study sought to determine the impact of MAFLD on both the anatomy and function of coronary plaques.

Materials And Methods: A total of 203 participants (including 728 plaques) with suspected coronary artery disease (CAD) who underwent coronary CT angiography (CCTA) and abdominal ultrasound were prospectively enrolled.

Circulating tumor DNA status and dynamics predict recurrence in patients with resected extrahepatic cholangiocarcinoma.

Background & Aims: Surgery is the only curative therapeutic option for resectable extrahepatic cholangiocarcinoma, but recurrence is common, and prognosis is poor. There is an unmet clinical need for improved decision-making regarding adjuvant chemotherapy (ACT). Herein, we evaluated the usefulness of monitoring longitudinal circulating tumor DNA (ctDNA) for molecular residual disease (MRD) in patients from the STAMP trial, which compares the efficacy of adjuvant capecitabine (CAP) vs.

Biochar Organic Fertilizer Combined with Indigenous Microorganisms Enhances the Growth of Landscape Grass Cultivated in a Substrate Mixed with Iron Tailings and Mining Topsoil.

Iron tailings from the mining process occupy vast land areas and pose a significant ecological risk. In order to reuse iron tailings resources and carry out in situ ecological restoration of a mine, in this study, a medium of mixed iron tailings and mining topsoil (m:m = 3:1) was used to plant landscape grasses, including L. ), (L.

Pharmacological Inhibition of the Spliceosome SF3b Complex by Pladienolide-B Elicits Craniofacial Developmental Defects in Mouse and Zebrafish.

Background: Mutations in genes encoding spliceosome components result in craniofacial structural defects in humans, referred to as spliceosomopathies. The SF3b complex is a crucial unit of the spliceosome, but model organisms generated through genetic modification of the complex do not perfectly mimic the phenotype of spliceosomopathies. Since the phenotypes are suggested to be determined by the extent of spliceosome dysfunction, an alternative experimental system that can seamlessly control SF3b function is needed.