Publications by authors named "M-L Paparella"
Article Synopsis
- - The study examined 500 patients with Brugada syndrome (BrS) to evaluate the genetic variants' presence and their relation to prognosis, discovering that about 20.8% had pathogenic variants in the SCN5A gene, which indicate a worse outcome.
- - Of the patients analyzed, 75 were found to have a gene variant, with the majority being missense variants; however, those without any genetic variants showed better protection against ventricular arrhythmias (VA).
- - The findings concluded that carrying a predicted loss of function variant—either in the SCN5A gene or other related genes—was a significant factor in predicting the likelihood of experiencing VA.
Aims: Hybrid atrial fibrillation (AF) ablation is a promising approach in non-paroxysmal AF. The aim of this study is to assess the long-term outcomes of hybrid ablation in a large cohort of patients after both an initial and as a redo procedure.
Methods And Results: All consecutive patients undergoing hybrid AF ablation at UZ Brussel from 2010 to 2020 were retrospectively evaluated.
Article Synopsis
- A study aimed to evaluate the effectiveness and outcomes of SCN5A gene testing in pediatric patients with Brugada syndrome (BrS) compared to adults, focusing on the presence of pathogenic variants.
- The research included 500 patients diagnosed with BrS over 30 years, revealing that 46% of the children tested positive for pathogenic variants, which was associated with a higher risk of ventricular arrhythmias (VAs).
- Ultimately, the study concluded that while 46% of pediatric patients have pathogenic variants, those who did showed a worse prognosis for arrhythmias compared to those without, with similar outcomes for both pediatric and adult patients regardless of their variant status.
Background: Non-contact charge density (CD) mapping allows a global visualization of left atrium (LA) activation and of activation patterns during atrial fibrillation (AF). The aim of this study was to analyze, with CD mapping, the changes in persistent AF induced by pulmonary vein isolation (PVI) and LA posterior wall isolation (LAPWI).
Methods: Patients undergoing PVI + LAPWI using the Arctic Front Advance PRO cryoballoon system were included in the study.
Background: Recent studies show that intraoperative mechanical ventilation using low tidal volumes (VT) can prevent postoperative pulmonary complications (PPCs). The aim of this individual patient data meta-analysis is to evaluate the individual associations between VT size and positive end-expiratory pressure (PEEP) level and occurrence of PPC.
Methods: Randomized controlled trials comparing protective ventilation (low VT with or without high levels of PEEP) and conventional ventilation (high VT with low PEEP) in patients undergoing general surgery.